Reactome | PTPN5 [nucleoplasm]

PTPN5 [nucleoplasm]

Stable Identifier

R-HSA-9008908

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-37 signaling (Homo sapiens)
        
        PTPNs gene transcription and translation (Homo sapiens)
        
        PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)
        
        PTPN5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54829 PTPN5

Gene Names

PTPN5

Chain

chain:1-565

Reference Genes

BioGPS Gene:84867 PTPN5

COSMIC (genes):PTPN5 PTPN5

CTD Gene:84867 PTPN5

dbSNP Gene:84867 PTPN5

ENSEMBL:ENSG00000110786 PTPN5

ENSEMBL:ENSG00000110786.18 PTPN5

HGNC:9657 PTPN5

KEGG Gene (Homo sapiens):84867 PTPN5

Monarch:84867 PTPN5

NCBI Gene:84867 PTPN5

OMIM:176879 PTPN5

UCSC:P54829 PTPN5

Reference Transcript

Other Identifiers

11727446_a_at

11747403_a_at

11750810_a_at

16736595

233471_PM_at

233471_at

236456_PM_at

236456_at

3365602

3365603

3365604

3365605

3365606

3365607

3365611

3365613

3365615

3365616

3365618

3365619

3365621

3365623

3365627

3365631

3365633

3365634

3365638

3365639

3365640

3365641

3365642

3365643

3365644

3365645

3365646

47884_at

7947076

84867

A_24_P409519

GE59045

GO:0001784

GO:0003824

GO:0004721

GO:0004725

GO:0005515

GO:0005634

GO:0005654

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006470

GO:0007165

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0019901

GO:0023052

GO:0030054

GO:0035335

GO:0036211

GO:0043226

GO:0140096

HMNXSV003017088

HMNXSV003023187

Hs.248318.0.S1_3p_at

Hs.79092.0.A1_3p_at

ILMN_1781073

ILMN_2363966

PH_hs_0004569

TC11001472.hg

U27831_at

Participates

as a member of

PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001265167.1, NP_008837.1, NP_116170.3, NP_001265165.1, NP_001265168.1, NP_001035059.1

OpenTargets

ENSG00000110786

GeneCards

P54829

ZINC - Substances

PTN5_HUMAN

HPA

ENSG00000110786-PTPN5

ZINC target

P54829

Ensembl

ENST00000396170, ENSP00000379473, ENSP00000379471, ENST00000396168, ENSG00000110786, ENSP00000351342, ENST00000358540

PRO

P54829

Pharos - Targets

P54829

ZINC - Predictions - Purchasable

PTN5_HUMAN

HMDB Protein

HMDBP08937

PDB

6H8R, 5OW1, 2CJZ, 5OVX, 2BV5, 5OVR, 2BIJ

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.527	2
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.527	2

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