Reactome | TRAPPC4 [cytosol]

TRAPPC4 [cytosol]

Stable Identifier

R-HSA-5683764

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SBDN, CGI-104, HSPC172, PTD009, TRAPP1, TRAPP2, TRAPP3, TRAPP core

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
      - TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)
        
        TRAPPCs [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)
        
        TRAPPCIII [cytosol] (Homo sapiens)
        
        TRAPPC4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y296 TRAPPC4

Gene Names

TRAPPC4, SBDN, CGI-104, HSPC172, PTD009

Chain

chain:1-219

Reference Genes

BioGPS Gene:51399 TRAPPC4

COSMIC (genes):TRAPPC4 TRAPPC4

CTD Gene:51399 TRAPPC4

dbSNP Gene:51399 TRAPPC4

ENSEMBL:ENSG00000196655 TRAPPC4

HGNC:19943 TRAPPC4

KEGG:hsa:51399 TRAPPC4

Monarch:51399 TRAPPC4

NCBI Gene:51399 TRAPPC4

OMIM:610971 TRAPPC4

UCSC:Q9Y296 TRAPPC4

Reference Transcript

Other Identifiers

11749400_a_at

11760996_at

16732088

217958_PM_at

217958_at

217959_PM_s_at

217959_s_at

234456_PM_at

234456_at

3351776

3351777

3351778

3351779

3351780

3351781

3351782

3351783

3351784

3351785

3351787

3351788

3351789

3351790

3351791

3351793

51399

7894041

7944375

91724_at

A_14_P122802

A_14_P134701

A_23_P127613

GE82084

GO:0000139

GO:0005515

GO:0005737

GO:0005783

GO:0005794

GO:0005795

GO:0005829

GO:0005886

GO:0006888

GO:0006901

GO:0006914

GO:0008021

GO:0016192

GO:0016358

GO:0030008

GO:0030425

GO:0031410

GO:0031982

GO:0043226

GO:0045202

GO:0045211

GO:0048208

GO:0048786

GO:0048856

GO:0065003

GO:0098839

GO:0099022

GO:1990071

GO:1990072

HMNXSV003046509

Hs.279901.1.A1_3p_at

ILMN_1814650

PH_hs_0014423

TC11001080.hg

g7706666_3p_at

Participates

as a component of

Other forms of this molecule

TRAPPC4 [plasma membrane]

Inferred To

trappc4 [cytosol] (Danio rerio)

trappc4 [cytosol] (Dictyostelium discoideum)

trappc4 [cytosol] (Xenopus tropicalis)

Trs23 [cytosol] (Drosophila melanogaster)

trs23 [cytosol] (Schizosaccharomyces pombe)

TRAPPC4 [cytosol] (Bos taurus)

TRAPPC4 [cytosol] (Canis familiaris)

TRAPPC4 [cytosol] (Gallus gallus)

TRAPPC4 [cytosol] (Plasmodium falciparum)

TRAPPC4 [cytosol] (Sus scrofa)

TRS23 [cytosol] (Saccharomyces cerevisiae)

trpp-4 [cytosol] (Caenorhabditis elegans)

Trappc4 [cytosol] (Mus musculus)

Trappc4 [cytosol] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000196655

ENSEMBL

ENST00000533632, ENSP00000405033, ENSP00000486496, ENST00000434101, ENST00000629713, ENSP00000436005, ENST00000629243, ENSP00000487467

HPA

ENSG00000196655-TRAPPC4

PRO

Q9Y296

Pharos - Targets

Q9Y296

Orphanet

TRAPPC4

PDB

2J3T, 2ZMV, 2JSN

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.735	5
UniProt:Q9Y5R8 TRAPPC1	3	TRAPPC1 [cytosol] (R-HSA-5683750) TRAPPC1 [extracellular region] (R-HSA-6806180) TRAPPC1 [azurophil granule lumen] (R-HSA-6799360)	0.725	5
UniProt:Q9BZR8 BCL2L14	1	BCL2L14 [cytosol] (R-HSA-6791317)	0.643	4
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.581	3
UniProt:O75865 TRAPPC6A	1	TRAPPC6A [cytosol] (R-HSA-5685733)	0.544	2
UniProt:Q96KC9 CABS1			0.527	2
UniProt:Q8IUR0 TRAPPC5	1	TRAPPC5 [cytosol] (R-HSA-5683765)	0.527	3
UniProt:Q9H0C5 BTBD1	1	BTBD1 [cytosol] (R-HSA-8851650)	0.527	2
UniProt:Q5T7N3 KANK4			0.527	2
UniProt:Q9P2M4 TBC1D14	1	TBC1D14 [recycling endosome] (R-HSA-8854764)	0.527	2
UniProt:Q8WVT3 TRAPPC12	1	TRAPPC12 [cytosol] (R-HSA-5683753)	0.527	3
UniProt:Q15771 RAB30	3	RAB30 [Golgi membrane] (R-HSA-8849598) GGC-RAB30 [cytosol] (R-HSA-8873972) RAB30 [cytosol] (R-HSA-8873677)	0.527	2
UniProt:Q9UL33 TRAPPC2L	1	TRAPPC2L [cytosol] (R-HSA-5683759)	0.508	3