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TRAPPC4 [cytosol]
Stable Identifier
R-HSA-5683764
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SBDN, CGI-104, HSPC172, PTD009, TRAPP1, TRAPP2, TRAPP3, TRAPP core
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
CSNK1D phosphorylates SEC23 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
Nucleotide exchange on RAB1 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)
TRAPPCs [cytosol] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
TRAPPCIII [cytosol] (Homo sapiens)
TRAPPC4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y296 TRAPPC4
Gene Names
TRAPPC4, SBDN, CGI-104, HSPC172, PTD009
Chain
chain:1-219
Reference Genes
BioGPS Gene:51399 TRAPPC4
COSMIC (genes):TRAPPC4 TRAPPC4
CTD Gene:51399 TRAPPC4
dbSNP Gene:51399 TRAPPC4
ENSEMBL:ENSG00000196655 TRAPPC4
ENSEMBL_homo_sapiens_GENE:ENSG00000196655.12 TRAPPC4
ENSEMBL_homo_sapiens_GENE:ENSG00000280495.5 TRAPPC4
HGNC:19943 TRAPPC4
KEGG Gene (Homo sapiens):51399 TRAPPC4
Monarch:51399 TRAPPC4
NCBI Gene:51399 TRAPPC4
OMIM:610971 TRAPPC4
UCSC:Q9Y296 TRAPPC4
Reference Transcript
RefSeq:NM_001318490.1 TRAPPC4
RefSeq:NM_001318486.1 TRAPPC4
RefSeq:NM_001318494.1 TRAPPC4
RefSeq:NM_001318489.1 TRAPPC4
RefSeq:NM_016146.5 TRAPPC4
RefSeq:NM_001318488.1 TRAPPC4
RefSeq:NM_001318492.1 TRAPPC4
Other Identifiers
11749400_a_at
16732088
217958_PM_at
217958_at
217959_PM_s_at
217959_s_at
3351777
3351778
3351779
3351782
3351784
3351788
3351789
3351790
3351793
51399
7894041
7944375
91724_at
A_14_P122802
A_14_P134701
A_23_P127613
GE82084
GO:0000139
GO:0005515
GO:0005737
GO:0005768
GO:0005783
GO:0005794
GO:0005795
GO:0005829
GO:0005886
GO:0006888
GO:0006901
GO:0006914
GO:0008021
GO:0016020
GO:0016192
GO:0016358
GO:0030008
GO:0030154
GO:0030425
GO:0031410
GO:0031982
GO:0043226
GO:0045202
GO:0045211
GO:0048208
GO:0048856
GO:0061024
GO:0065003
GO:0099022
GO:1990071
GO:1990072
HMNXSV003046509
ILMN_1814650
PH_hs_0014423
g7706666_3p_at
Participates
as a component of
TRAPPCIII [cytosol] (Homo sapiens)
TRAPPCII [cytosol] (Homo sapiens)
Other forms of this molecule
TRAPPC4 [plasma membrane]
Inferred To
trappc4 [cytosol]
(Dictyostelium discoideum)
trappc4 [cytosol]
(Xenopus tropicalis)
Trs23 [cytosol]
(Drosophila melanogaster)
trs23 [cytosol]
(Schizosaccharomyces pombe)
TRAPPC4 [cytosol]
(Bos taurus)
TRAPPC4 [cytosol]
(Canis familiaris)
TRAPPC4 [cytosol]
(Gallus gallus)
TRAPPC4 [cytosol]
(Plasmodium falciparum)
TRAPPC4 [cytosol]
(Sus scrofa)
zgc:73260 [cytosol]
(Danio rerio)
TRS23 [cytosol]
(Saccharomyces cerevisiae)
trpp-4 [cytosol]
(Caenorhabditis elegans)
Trappc4 [cytosol]
(Mus musculus)
Trappc4 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001305417.1
,
NP_001305419.1
,
NP_001305421.1
,
NP_001305418.1
,
NP_001305423.1
,
NP_057230.1
,
NP_001305415.1
OpenTargets
ENSG00000196655
GeneCards
Q9Y296
HPA
ENSG00000196655-TRAPPC4
Ensembl
ENSP00000405033
,
ENST00000434101
,
ENSP00000487467
,
ENST00000629713
,
ENST00000629243
,
ENSP00000486496
,
ENST00000533632
,
ENSG00000196655
,
ENSP00000436005
,
ENSG00000280495
PRO
Q9Y296
Pharos - Targets
Q9Y296
Orphanet
29244
PDB
2JSN
,
2ZMV
,
2J3T
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96QF0 RAB3IP
1
RAB3IP [cytosol]
(R-HSA-5617610)
0.735
5
UniProt:P28482 MAPK1
18
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.581
3
UniProt:O75865 TRAPPC6A
1
TRAPPC6A [cytosol]
(R-HSA-5685733)
0.544
2
UniProt:Q9BZR8 BCL2L14
1
BCL2L14 [cytosol]
(R-HSA-6791317)
0.527
2
UniProt:Q9Y5R8 TRAPPC1
3
TRAPPC1 [extracellular region]
(R-HSA-6806180)
TRAPPC1 [azurophil granule lumen]
(R-HSA-6799360)
TRAPPC1 [cytosol]
(R-HSA-5683750)
0.508
2
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