Reactome | PTPN7 [cytosol]

PTPN7 [cytosol]

Stable Identifier

R-HSA-9635737

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein phosphatase non-receptor type 7, HEPTP, Hematopoietic protein-tyrosine phosphatase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35236 PTPN7

Gene Names

PTPN7

Chain

chain:1-360

Reference Genes

BioGPS Gene:5778 PTPN7

COSMIC (genes):PTPN7 PTPN7

CTD Gene:5778 PTPN7

dbSNP Gene:5778 PTPN7

ENSEMBL:ENSG00000143851 PTPN7

HGNC:9659 PTPN7

KEGG:hsa:5778 PTPN7

Monarch:5778 PTPN7

NCBI Gene:5778 PTPN7

OMIM:176889 PTPN7

UCSC:P35236 PTPN7

Reference Transcript

Other Identifiers

11732169_a_at

11748520_a_at

11748867_a_at

11749268_a_at

11749269_x_at

11750505_a_at

11750506_x_at

11760014_x_at

1554860_3p_at

1554860_PM_at

1554860_at

16697995

1760_s_at

204852_PM_s_at

204852_s_at

2451156

2451157

2451158

2451159

2451160

2451161

2451162

2451163

2451164

2451165

2451166

2451167

2451168

2451169

2451170

2451171

2451172

2451173

2451174

2451175

2451176

2451177

2451178

2451179

2451180

2451181

2451182

2451183

2451184

2451185

39672_at

5778

72285_at

7923406

A_23_P201778

A_24_P276808

D11327_s_at

GE81200

GO:0000165

GO:0003824

GO:0004721

GO:0004725

GO:0004726

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0006470

GO:0009898

GO:0015630

GO:0016311

GO:0016787

GO:0043226

GO:0072686

GO:0140096

HMNXSV003014084

HMNXSV003046197

Hs2.35.4.S1_3p_x_at

ILMN_1715214

ILMN_2257223

PH_hs_0024615

TC01003700.hg

TC01006042.hg

g4506298_3p_a_at

Participates

as an input of

PTPN7 binds p-T,Y-MAPK (Homo sapiens)

as a component of

Other forms of this molecule

PTPN7 [nucleoplasm]

Inferred To

pyp2 [cytosol] (Schizosaccharomyces pombe)

pyp1 [cytosol] (Schizosaccharomyces pombe)

PTPN7 [cytosol] (Bos taurus)

PTPN7 [cytosol] (Mus musculus)

PTPN7 [cytosol] (Rattus norvegicus)

ptpC [cytosol] (Dictyostelium discoideum)

ptpA1-2 [cytosol] (Dictyostelium discoideum)

PTP2 [cytosol] (Saccharomyces cerevisiae)

Homologues of PTPN7 [cytosol] (Dictyostelium discoideum)

Homologues of PTPN7 [cytosol] (Saccharomyces cerevisiae)

Homologues of PTPN7 [cytosol] (Schizosaccharomyces pombe)

PTP3 [cytosol] (Saccharomyces cerevisiae)

PTP-ER [cytosol] (Drosophila melanogaster)

PTP1 [cytosol] (Saccharomyces cerevisiae)

ptpB [cytosol] (Dictyostelium discoideum)

pyp3 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_002823.3, NP_542155.1

OpenTargets

ENSG00000143851

ENSEMBL

ENST00000367279, ENSP00000420506, ENST00000691036, ENSP00000356248, ENST00000495688, ENSP00000509436, ENST00000309017, ENSP00000309116, ENST00000477554, ENSP00000418416

HPA

ENSG00000143851-PTPN7

ZINC - Substances

PTN7_HUMAN

ZINC target

P35236

PRO

P35236

Pharos - Targets

P35236

GlyGen

P35236

ZINC - Predictions - Purchasable

PTN7_HUMAN

PDB

2QDC, 3O4S, 3O4T, 3O4U, 2QDM, 2A3K, 2QDP, 2HVL, 2GPH, 3D44, 3D42, 1ZC0, 2GP0

HMDB Protein

HMDBP08161

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.767	6
UniProt:P47811 Mapk14	7	p-T180,Y182-Mapk14 [nucleoplasm] (R-MMU-1605486) phospho-MAP kinase p38 alpha [cytosol] (R-MMU-448842) MAP kinase p38 alpha [cytosol] (R-MMU-448843) MAPK14 [nucleoplasm] (R-MMU-446223) MAPK14 [secretory granule lumen] (R-MMU-6803300) MAPK14 [extracellular region] (R-MMU-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-MMU-6803280)	0.589	2
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:Q2TAC2 CCD57			0.556	3

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