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PTPN7 [cytosol]
Stable Identifier
R-HSA-9635737
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein phosphatase non-receptor type 7, HEPTP, Hematopoietic protein-tyrosine phosphatase
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PTPN7 binds p-T,Y-MAPK (Homo sapiens)
PTPN7 [cytosol] (Homo sapiens)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
PTPN7 [cytosol] (Homo sapiens)
PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)
PTPN7 [cytosol] (Homo sapiens)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
PTPN7 [cytosol] (Homo sapiens)
PTPN7:p-T-MAPK dimers [cytosol] (Homo sapiens)
PTPN7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35236 PTPN7
Gene Names
PTPN7
Chain
chain:1-360
Reference Genes
BioGPS Gene:5778 PTPN7
COSMIC (genes):PTPN7 PTPN7
CTD Gene:5778 PTPN7
dbSNP Gene:5778 PTPN7
ENSEMBL:ENSG00000143851 PTPN7
HGNC:9659 PTPN7
KEGG Gene (Homo sapiens):5778 PTPN7
Monarch:5778 PTPN7
NCBI Gene:5778 PTPN7
OMIM:176889 PTPN7
UCSC:P35236 PTPN7
Reference Transcript
RefSeq:NM_080588.2 PTPN7
RefSeq:NM_002832.3 PTPN7
Other Identifiers
0003190133
0004780020
11732169_a_at
11748520_a_at
11748867_a_at
11749268_a_at
11749269_x_at
11750505_a_at
11750506_x_at
11760014_x_at
16697995
1760_s_at
204852_PM_s_at
204852_s_at
2451156
2451157
2451158
2451159
2451160
2451161
2451162
2451163
2451166
2451167
2451169
2451171
2451173
2451175
2451176
2451177
2451180
2451181
2451182
2451183
2451184
2451185
39672_at
5778
7923406
A_23_P201778
A_24_P276808
D11327_s_at
GE81200
GO:0000165
GO:0003674
GO:0004721
GO:0004725
GO:0004726
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006464
GO:0006470
GO:0007165
GO:0008150
GO:0009898
GO:0015630
GO:0016311
GO:0016787
GO:0016791
GO:0035335
GO:0043226
GO:0072686
HMNXSV003014084
HMNXSV003046197
ILMN_1715214
ILMN_1749998
ILMN_2257223
PH_hs_0024615
TC01003700.hg
TC01006042.hg
g4506298_3p_a_at
Participates
as a component of
PTPN7:p-T-MAPK dimers [cytosol] (Homo sapiens)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
as an input of
PTPN7 binds p-T,Y-MAPK (Homo sapiens)
Other forms of this molecule
PTPN7 [nucleoplasm]
Inferred To
pyp2 [cytosol]
(Schizosaccharomyces pombe)
pyp1 [cytosol]
(Schizosaccharomyces pombe)
PTPN7 [cytosol]
(Bos taurus)
PTPN7 [cytosol]
(Caenorhabditis elegans)
PTPN7 [cytosol]
(Canis familiaris)
PTP2 [cytosol]
(Saccharomyces cerevisiae)
Ptpn7 [cytosol]
(Mus musculus)
Ptpn7 [cytosol]
(Rattus norvegicus)
Homologues of PTPN7 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PTPN7 [cytosol]
(Schizosaccharomyces pombe)
PTP3 [cytosol]
(Saccharomyces cerevisiae)
PTP-ER [cytosol]
(Drosophila melanogaster)
PTP1 [cytosol]
(Saccharomyces cerevisiae)
ptpB [cytosol]
(Dictyostelium discoideum)
pyp3 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_542155.1
,
NP_002823.3
OpenTargets
ENSG00000143851
ZINC - Substances
PTN7_HUMAN
ZINC target
P35236
PRO
P35236
PDB
1ZC0
,
2GPH
,
3D42
,
2QDC
,
2HVL
,
2GP0
,
3O4T
,
3D44
,
2QDM
,
3O4U
,
3O4S
,
2A3K
,
2QDP
ZINC - Investigational
PTN7_HUMAN
GeneCards
P35236
HPA
ENSG00000143851-PTPN7
Ensembl
ENSG00000143851
,
ENST00000367279
,
ENST00000309017
,
ENSP00000356248
,
ENSP00000420506
,
ENST00000495688
,
ENSP00000309116
Pharos - Targets
P35236
ZINC - Predictions - Purchasable
PTN7_HUMAN
HMDB Protein
HMDBP08161
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28482 MAPK1
18
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.767
6
UniProt:P47811 Mapk14
7
Mapk14 [secretory granule lumen]
(R-MMU-6803300)
Mapk14 [extracellular region]
(R-MMU-6806453)
Mapk14 [ficolin-1-rich granule lumen]
(R-MMU-6803280)
Mapk14 [nucleoplasm]
(R-MMU-446223)
MAP kinase p38 alpha [cytosol]
(R-MMU-448843)
phospho-MAP kinase p38 alpha [cytosol]
(R-MMU-448842)
p-T180,Y182-Mapk14 [nucleoplasm]
(R-MMU-1605486)
0.589
2
UniProt:Q2TAC2 CCD57
0.556
3
UniProt:Q53SE7 Q53SE7
0.556
3
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