Reactome | p-T202,Y204-MAPK3 [cytosol]

p-T202,Y204-MAPK3 [cytosol]

Stable Identifier

R-HSA-109842

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T202,Y204-ERK1, Mitogen-activated protein kinase 3 , Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase 1, MAPK 1, p44-ERK1, ERT2, p44-MAPK, Microtubule- associated protein-2 kinase, phospho-ERK-1

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - Regulation of HSF1-mediated heat shock response (Homo sapiens)
      - Constitutive phosphorylation by pERK1/2 (Homo sapiens)
        
        p-T,Y MAPK dimers [cytosol] (Homo sapiens)
        
        p-T202, Y204 MAPK3 dimer [cytosol] (Homo sapiens)
        
        p-T202,Y204-MAPK3 [cytosol] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        RSK activation (Homo sapiens)
        
        ERKs phosphorylate RSKs (Homo sapiens)
        
        p-T,Y MAPK dimers [cytosol] (Homo sapiens)
        
        p-T202, Y204 MAPK3 dimer [cytosol] (Homo sapiens)
        
        p-T202,Y204-MAPK3 [cytosol] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - Cytochrome c-mediated apoptotic response (Homo sapiens)
        
        Formation of apoptosome (Homo sapiens)
        
        Regulation of the apoptosome activity (Homo sapiens)
        
        CASP9 is phosphorylated at T412 (Homo sapiens)
        
        p-T,Y MAPK dimers [cytosol] (Homo sapiens)
        
        p-T202, Y204 MAPK3 dimer [cytosol] (Homo sapiens)
        
        p-T202,Y204-MAPK3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P27361 MAPK3

Gene Names

MAPK3, ERK1, PRKM3

Chain

initiator methionine:, chain:2-379

Reference Genes

BioGPS Gene:5595 MAPK3

COSMIC (genes):MAPK3 MAPK3

CTD Gene:5595 MAPK3

dbSNP Gene:5595 MAPK3

ENSEMBL:ENSG00000102882 MAPK3

ENSEMBL_homo_sapiens_GENE:ENSG00000102882.12 MAPK3

HGNC:6877 MAPK3

KEGG Gene (Homo sapiens):5595 MAPK3

Monarch:5595 MAPK3

NCBI Gene:5595 MAPK3

OMIM:601795 MAPK3

UCSC:P27361 MAPK3

Reference Transcript

Other Identifiers

1000_at

11717543_x_at

16825661

212046_3p_x_at

212046_PM_x_at

212046_x_at

3687493

3687495

3687496

3687497

3687498

3687499

3687500

3687501

3687503

3687505

3687508

3687512

5595

8000811

A_23_P37910

GE79221

GO:0000165

GO:0000166

GO:0001784

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005770

GO:0005783

GO:0005788

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005901

GO:0005925

GO:0006351

GO:0006355

GO:0006468

GO:0006914

GO:0006915

GO:0006974

GO:0007010

GO:0007049

GO:0008286

GO:0009887

GO:0010759

GO:0012501

GO:0014032

GO:0014044

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0019233

GO:0019902

GO:0023052

GO:0030154

GO:0030278

GO:0030509

GO:0030641

GO:0030878

GO:0031143

GO:0031281

GO:0031410

GO:0031663

GO:0032200

GO:0032212

GO:0032496

GO:0032872

GO:0033554

GO:0034198

GO:0034614

GO:0035556

GO:0036211

GO:0038083

GO:0038133

GO:0042473

GO:0042552

GO:0042770

GO:0042802

GO:0043226

GO:0043330

GO:0045944

GO:0048009

GO:0048538

GO:0048856

GO:0048870

GO:0050804

GO:0050877

GO:0051216

GO:0051403

GO:0051493

GO:0051973

GO:0060020

GO:0060324

GO:0060425

GO:0060440

GO:0061308

GO:0070161

GO:0070371

GO:0070374

GO:0070498

GO:0070849

GO:0071260

GO:0071276

GO:0071356

GO:0072584

GO:0090170

GO:0098542

GO:0098792

GO:0098978

GO:0106310

GO:0120041

GO:0140096

GO:0140297

GO:1904262

GO:1904355

GO:1904417

GO:2000641

HMNXSV003008674

HMNXSV003058073

Hs.861.0.S1_3p_at

Hs.861.0.S1_3p_x_at

ILMN_1667260

ILMN_2402341

PH_hs_0000106

TC16001021.hg

X60188_at

Participates

as an output of

Dissociation of p-T,Y-MAPK3:MAP2K1 (Homo sapiens)

as a component of

as a member of

p-T,Y MAPKs [cytosol] (Homo sapiens)

Other forms of this molecule

MAPK3 [endoplasmic reticulum lumen]

p-T202-MAPK3 [cytosol]

MAPK3 [nucleoplasm]

MAPK3 [cytosol]

p-T202,Y204-MAPK3 [nucleoplasm]

Inferred To

phospho-MAPK3 [cytosol] (Canis familiaris)

phospho-p-T202,Y204-MAPK3 [cytosol] (Bos taurus)

phospho-p-T202,Y204-MAPK3 [cytosol] (Caenorhabditis elegans)

phospho-p-T202,Y204-MAPK3 [cytosol] (Danio rerio)

phospho-p-T202,Y204-MAPK3 [cytosol] (Dictyostelium discoideum)

phospho-p-T202,Y204-MAPK3 [cytosol] (Drosophila melanogaster)

phospho-p-T202,Y204-MAPK3 [cytosol] (Mus musculus)

phospho-p-T202,Y204-MAPK3 [cytosol] (Plasmodium falciparum)

phospho-p-T202,Y204-MAPK3 [cytosol] (Rattus norvegicus)

phospho-p-T202,Y204-MAPK3 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T202,Y204-MAPK3 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T202,Y204-MAPK3 [cytosol] (Sus scrofa)

Homologues of p-T202,Y204-MAPK3 [cytosol] (Saccharomyces cerevisiae)

Homologues of p-T202,Y204-MAPK3 [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-threonine at 202

Coordinate

202

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 204

Coordinate

204

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001035145.1, NP_002737.2, NP_001103361.1

ZINC - World Drugs

MK03_HUMAN

Guide to Pharmacology - Targets

1494

OpenTargets

ENSG00000102882

ZINC - FDA approved

MK03_HUMAN

ZINC - Substances

MK03_HUMAN

ZINC - Biogenic

MK03_HUMAN

ZINC target

P27361

PRO

P27361

PDB

6GES, 4QTB, 2ZOQ

ZINC - Investigational

MK03_HUMAN

ZINC - Metabolites

MK03_HUMAN

HPA

ENSG00000102882-MAPK3

GeneCards

P27361

Ensembl

ENST00000263025, ENSP00000327293, ENST00000395199, ENSP00000378628, ENST00000395202, ENSP00000263025, ENSG00000102882, ENST00000322266, ENSP00000378625

Pharos - Targets

P27361

ZINC - Predictions - Purchasable

MK03_HUMAN

HMDB Protein

HMDBP01263

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49366 DHPS	1	DHPS [cytosol] (R-HSA-204630)	0.919	10
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.774	8
UniProt:Q16828 DUSP6	2	DUSP6 [cytosol] (R-HSA-5675343) DUSP6 [nucleoplasm] (R-HSA-2871619)	0.744	5
UniProt:Q15121 PEA15	1	PEA15 [cytosol] (R-HSA-5675204)	0.743	5
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.706	3
UniProt:Q15349 RPS6KA2	7	RPS6KA2 [nucleoplasm] (R-HSA-199861) p-4S,T356,T570-RPS6KA2 [nucleoplasm] (R-HSA-199871) RPS6KA2 [cytosol] (R-HSA-444252) p-T356,S360,T570-RPS6KA2 [cytosol] (R-HSA-9619955) p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619869) p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619984) p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (R-HSA-444290)	0.706	5
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.697	5
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.691	5
UniProt:Q62132 PTPRR			0.667	3
UniProt:P54829 PTPN5	1	PTPN5 [nucleoplasm] (R-HSA-9008908)	0.643	3
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.623	2
UniProt:P23467 PTPRB	3	PTPRB [specific granule membrane] (R-HSA-6799638) PTPRB [plasma membrane] (R-HSA-437247) PTPRB [tertiary granule membrane] (R-HSA-6801032)	0.623	2
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.618	5
UniProt:Q99956 DUSP9	1	DUSP9 [cytosol] (R-HSA-5675351)	0.615	3
UniProt:P51812 RPS6KA3	7	RPS6KA3 [nucleoplasm] (R-HSA-199869) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [cytosol] (R-HSA-444250) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286)	0.615	5
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.571	2
UniProt:Q9EPI6 NSMF			0.558	2
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.558	2
UniProt:Q96NJ5 KLH32			0.556	3
UniProt:Q96HT8 MR1L1			0.556	3
UniProt:Q8N490 PNKD			0.556	4
UniProt:Q49AJ0-4 Q49AJ04			0.556	3
UniProt:Q9HCU0 CD248			0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:P13051-2 UNG			0.556	3
UniProt:Q9ULW8 PADI3	2	PADI3 [cytosol] (R-HSA-1183173) PADI3 [nucleoplasm] (R-HSA-6793444)	0.556	3
UniProt:Q9UK32 RPS6KA6	5	RPS6KA6 [cytosol] (R-HSA-444266) p-T368,S372,T581-RPS6KA6 [cytosol] (R-HSA-9619958) p-S232,T368,S372,S389,T581,S742-RPS6KA6 [cytosol] (R-HSA-9619870) p-T368,S372,S389,T581,S742-RPS6KA6 [cytosol] (R-HSA-9619985) p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm] (R-HSA-444293)	0.547	2
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.527	2
UniProt:Q9H8X9 ZDHHC11	1	ZDHHC11 [Golgi membrane] (R-HSA-9774147)	0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	3
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.527	2
UniProt:Q92576 PHF3			0.527	2
UniProt:Q7Z7G2 CPLX4			0.527	2
UniProt:O94822 LTN1	1	LTN1 [cytosol] (R-HSA-5688967)	0.527	2
UniProt:Q9H4H8 FAM83D	1	FAM83D [cytosol] (R-HSA-9852722)	0.527	3
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.527	2
UniProt:P50548 ERF	3	p-T526-ERF [nucleoplasm] (R-HSA-3209166) p-T526-ERF [cytosol] (R-HSA-3209167) ERF [nucleoplasm] (R-HSA-2534321)	0.527	2
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.499	2

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