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About
What is Reactome ?
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Team
Scientific Advisory Board
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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p-Y239,Y240,Y317-SHC1-2 [cytosol]
Stable Identifier
R-HSA-1433505
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y239,Y240,Y317-SHC1 p52, SHC-transforming protein 1, SHC1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK mutants phosphorylate SHC1 (Homo sapiens)
ALK fusion dimers:p-3Y SHC1 [cytosol] (Homo sapiens)
p-3Y SHC1-2, p-3Y SHC1-3 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)
ALK fusion dimers:p-3Y SHC1 [cytosol] (Homo sapiens)
p-3Y SHC1-2, p-3Y SHC1-3 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
ALK fusion dimers:p-3Y SHC1:GRB2 [cytosol] (Homo sapiens)
p-3Y SHC1-2, p-3Y SHC1-3 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Activation of RAC1 by VAV2/3 (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of BTK by p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Release of p-PLCG1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Autophosphorylation of BTK/ITK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Autophosphorylation of PAK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of SHC by SYK kinase (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of VAV to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
PI3K associates with phosphorylated GAB2 (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
SHC1 events in ERBB2 signaling (Homo sapiens)
Activated PKC phosphorylates SHC1 (Homo sapiens)
p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Signaling by LTK (Homo sapiens)
Active LTK receptor phosphorylates SHC1 (Homo sapiens)
Active LTK:p-3Y SHC1 [plasma membrane] (Homo sapiens)
p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Active LTK recruits GRB2:SOS1 (Homo sapiens)
Active LTK:p-3Y SHC1 [plasma membrane] (Homo sapiens)
p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Active LTK:p-3Y SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
SHC-related events triggered by IGF1R (Homo sapiens)
GRB2-1:SOS1 binds p-3Y-SHC1 (Homo sapiens)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
IGF1R phosphorylates SHC1 (Homo sapiens)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-3Y-SHC1 dissociates from IGF1R (Homo sapiens)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29353-2 SHC1
Gene Names
SHC1, SHC, SHCA
Participates
as a member of
p-3Y SHC1-2, p-3Y SHC1-3 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol] (Homo sapiens)
as a candidate of
p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Homo sapiens)
as an output of
Phosphorylation of SHC by SYK kinase (Homo sapiens)
as an input of
Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)
as a component of
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y239,Y240,Y317-SHC1-2 [plasma membrane]
p-Y317-SHC1-2 [cytosol]
SHC1-2 [cytosol]
p-S29,3Y-SHC1-2 [cytosol]
SHC1-2 [plasma membrane]
Inferred From
p-Y239,Y240,Y313-Shc1 [cytosol]
(Mus musculus)
Inferred To
phospho-Shc1 [cytosol]
(Mus musculus)
phospho-Shc1 [cytosol]
(Rattus norvegicus)
phospho-SHC1 [cytosol]
(Bos taurus)
phospho-SHC1 [cytosol]
(Canis familiaris)
phospho-SHC1 [cytosol]
(Gallus gallus)
phospho-SHC1 [cytosol]
(Sus scrofa)
phospho-Shc [cytosol]
(Drosophila melanogaster)
Ghost homologue of p-Y239,Y240,Y317-SHC1-2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 239
Coordinate
239
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 240
Coordinate
240
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 317
Coordinate
317
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_003020.2
,
NP_001123512.1
,
NP_001189788.1
,
NP_001123513.1
,
NP_892113.4
OpenTargets
ENSG00000160691
ENSEMBL
ENSG00000160691
,
ENSP00000357435
,
ENST00000368445
,
ENSP00000401303
,
ENST00000368453
,
ENSP00000357430
,
ENST00000368450
,
ENST00000448116
,
ENSP00000357438
HPA
ENSG00000160691-SHC1
GeneCards
SHC1
ZINC - Substances
SHC1_HUMAN
ZINC target
P29353
PRO
P29353
Pharos - Targets
P29353
GlyGen
P29353
ZINC - Predictions - Purchasable
SHC1_HUMAN
PDB
1OY2
,
2L1C
,
1TCE
,
1MIL
,
4JMH
,
1N3H
,
1SHC
,
1QG1
,
5CZI
,
4XWX
,
6DM4
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.976
33
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.976
44
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.856
9
UniProt:P62994 Grb2
3
Grb2 [cytosol]
(R-RNO-55929)
Grb2 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-74686)
0.822
5
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.821
16
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.816
6
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
0.77
5
UniProt:P21860 ERBB3
0.762
7
UniProt:O95782 AP2A1
5
AP2A1 [endolysosome membrane]
(R-HSA-6784829)
AP2A1 [plasma membrane]
(R-HSA-177494)
AP2A1 [endocytic vesicle membrane]
(R-HSA-416641)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138449)
AP2A1 [cytosol]
(R-HSA-182143)
0.725
6
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.643
5
UniProt:O94973 AP2A2
6
AP2A2(1-939) [endolysosome membrane]
(R-HSA-6784819)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-HSA-6800414)
AP2A2(1-939) [secretory granule membrane]
(R-HSA-6800412)
AP2A2(1-939) [plasma membrane]
(R-HSA-177502)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138448)
AP2A2(1-939) [cytosol]
(R-HSA-182155)
0.643
4
UniProt:Q16832 DDR2
1
DDR2 [plasma membrane]
(R-HSA-211419)
0.632
3
UniProt:Q15303 ERBB4
0.609
6
UniProt:Q12774 ARHGEF5
1
ARHGEF5 [cytosol]
(R-HSA-8873909)
0.597
4
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.589
6
UniProt:P06213 INSR
6
INSR(28-758) [plasma membrane]
(R-HSA-74668)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
0.573
2
UniProt:Q9UM73 ALK
20
p-7Y ALK T1087I [plasma membrane]
(R-HSA-9723885)
p-7Y ALK R1061Q [plasma membrane]
(R-HSA-9723884)
p-7Y ALK L1196M [plasma membrane]
(R-HSA-9700464)
p-7Y ALK M1166R [plasma membrane]
(R-HSA-9700477)
p-Y ALK S1206C [plasma membrane]
(R-HSA-9715292)
p- 7Y ALK L1122V [plasma membrane]
(R-HSA-9715294)
p-7Y ALK E1384K [plasma membrane]
(R-HSA-9715285)
p-7Y ALK L1196Q [plasma membrane]
(R-HSA-9700476)
p-7Y ALK V1180L [plasma membrane]
(R-HSA-9715289)
p-7Y ALK G1201R [plasma membrane]
(R-HSA-9701860)
p-7Y ALK I1171T [plasma membrane]
(R-HSA-9700489)
p-7Y ALK R1275L [plasma membrane]
(R-HSA-9699800)
p-7Y ALK F1174C [plasma membrane]
(R-HSA-9699821)
p-7Y ALK F1174V [plasma membrane]
(R-HSA-9699921)
p-7Y ALK M1166N [plasma membrane]
(R-HSA-9723299)
p-7Y ALK M1166T [plasma membrane]
(R-HSA-9700486)
p-7Y ALK Y1239H [plasma membrane]
(R-HSA-9715290)
p-7Y ALK R1275* [plasma membrane]
(R-HSA-9699915)
p-7Y ALK I1171S [plasma membrane]
(R-HSA-9714063)
p-7Y ALK G1128S [plasma membrane]
(R-HSA-9700462)
0.569
3
UniProt:P29353 SHC1
5
p-Y-SHC1 [cytosol]
(R-HSA-162568)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
0.564
2
UniProt:Q07889 SOS1
3
SOS1 [cytosol]
(R-HSA-64847)
SOS1 [plasma membrane]
(R-HSA-983559)
p-4S-SOS1 [cytosol]
(R-HSA-109821)
0.564
2
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.564
2
UniProt:Q13137 CACO2
0.553
3
UniProt:P26954
4
phospho-Csf2rb2 [plasma membrane]
(R-MMU-914092)
phospho-Csf2rb2 [plasma membrane]
(R-MMU-914170)
Csf2rb2 [plasma membrane]
(R-MMU-879960)
phospho-Csf2rb2 [plasma membrane]
(R-MMU-912312)
0.544
4
UniProt:Q9UQC2 GAB2
5
p-Y-GAB2 [cytosol]
(R-HSA-912529)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
GAB2 [cytosol]
(R-HSA-508239)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
p-Y643-GAB2 [cytosol]
(R-HSA-9677149)
0.544
2
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.544
2
UniProt:P16573
11
Ceacam1 [extracellular region]
(R-RNO-8941137-3)
Ceacam1 [plasma membrane]
(R-RNO-8940816-3)
Ceacam1 [extracellular region]
(R-RNO-8870747-3)
Ceacam1 [extracellular region]
(R-RNO-8870766-3)
Ceacam1 [extracellular region]
(R-RNO-8870757-3)
Ceacam1 [extracellular region]
(R-RNO-8870759-3)
Ceacam1 [plasma membrane]
(R-RNO-197706-3)
Ceacam1 [specific granule membrane]
(R-RNO-6806076-3)
Ceacam1 [specific granule membrane]
(R-RNO-6799528)
Ceacam1 [plasma membrane]
(R-RNO-197701)
Ceacam1 [tertiary granule membrane]
(R-RNO-6800953)
0.544
3
UniProt:P63010 AP2B1
4
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
0.527
3
UniProt:Q05655 PRKCD
12
PRKCD [cytosol]
(R-HSA-58200)
PRKCD(1-329) [cytosol]
(R-HSA-212547)
PRKCD(330-676) [cytosol]
(R-HSA-212551)
active p-T507,S645,S664-PRKCD [plasma membrane]
(R-HSA-5607635)
p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
(R-HSA-198294)
p-T507,S645,S664-PRKCD [cytosol]
(R-HSA-5218734)
p-T507-PRKCD [cytosol]
(R-HSA-5218746)
PRKCD(330-676) [azurophil granule lumen]
(R-HSA-6799221)
PRKCD(1-329) [azurophil granule lumen]
(R-HSA-6799219)
PRKCD(1-329) [extracellular region]
(R-HSA-6806226)
PRKCD(330-676) [extracellular region]
(R-HSA-6806199)
PRKCD(1-676) [nucleoplasm]
(R-HSA-450606)
0.527
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
UniProt:Q93008 USP9X
1
USP9X [cytosol]
(R-HSA-870499)
0.527
3
UniProt:Q38SD2 LRRK1
0.527
3
UniProt:Q8TF42 UBS3B
0.527
3
UniProt:P32927 CSF2RB
6
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
0.527
4
UniProt:Q9H706 GARE1
0.527
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.519
6
UniProt:P03495 NS1
0.508
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.483
3
UniProt:Q02763 TEK
2
p-5Y,S1119-TEK [plasma membrane]
(R-HSA-204772)
TEK [plasma membrane]
(R-HSA-197755)
0.462
2
UniProt:Q08345-1 DDR1
0.462
4
UniProt:A9UF07 A9UF07
0.462
4
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
NTRK1 [plasma membrane]
(R-HSA-3008784)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
0.462
2
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