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About
What is Reactome ?
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Table of Contents
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p-Y239,Y240,Y317-SHC1-2 [cytosol]
Stable Identifier
R-HSA-1433505
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y239,Y240,Y317-SHC1 p52, SHC-transforming protein 1, SHC1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK mutants phosphorylate SHC1 (Homo sapiens)
ALK fusion dimers:p-3Y SHC1 [cytosol] (Homo sapiens)
p-3Y SHC1-2, p-3Y SHC1-3 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)
ALK fusion dimers:p-3Y SHC1 [cytosol] (Homo sapiens)
p-3Y SHC1-2, p-3Y SHC1-3 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
ALK fusion dimers:p-3Y SHC1:GRB2 [cytosol] (Homo sapiens)
p-3Y SHC1-2, p-3Y SHC1-3 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Activation of RAC1 by VAV2/3 (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of BTK by p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Release of p-PLCG1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Autophosphorylation of BTK/ITK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Autophosphorylation of PAK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of SHC by SYK kinase (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of VAV to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
PI3K associates with phosphorylated GAB2 (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
SHC1 events in ERBB2 signaling (Homo sapiens)
Activated PKC phosphorylates SHC1 (Homo sapiens)
p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
SHC-related events triggered by IGF1R (Homo sapiens)
GRB2-1:SOS1 binds p-3Y-SHC1 (Homo sapiens)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
IGF1R phosphorylates SHC1 (Homo sapiens)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-3Y-SHC1 dissociates from IGF1R (Homo sapiens)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-Y239,Y240,Y317-SHC1-2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29353-2 SHC1
Gene Names
SHC1, SHC, SHCA
Other Identifiers
11727363_a_at
11727364_s_at
11732136_a_at
11758297_s_at
16693891
16693898
201469_PM_s_at
201469_s_at
214853_PM_s_at
214853_s_at
2436980
2436981
2436982
2436983
2436984
2436986
2436987
2436988
2436989
2436990
2436991
2436992
2436995
2436996
2436997
2436998
2436999
2437000
2437002
2437003
2437004
2437005
2437006
2437007
2437009
2437010
2437011
2437012
2437013
2437014
2437015
2437016
2437018
3759015
3759016
38118_at
6464
7920600
A_23_P200443
A_24_P68585
GE59385
GO:0001525
GO:0001784
GO:0005068
GO:0005154
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005543
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0007010
GO:0007155
GO:0007165
GO:0007169
GO:0007173
GO:0007176
GO:0007507
GO:0008284
GO:0008286
GO:0008289
GO:0012501
GO:0016525
GO:0019901
GO:0023052
GO:0030971
GO:0031532
GO:0035556
GO:0036211
GO:0042127
GO:0042742
GO:0043066
GO:0043226
GO:0043410
GO:0043539
GO:0045892
GO:0045893
GO:0046875
GO:0048009
GO:0048408
GO:0048856
GO:0060090
GO:0070374
GO:0070435
GO:0071363
GO:0071864
GO:0090322
GO:0098542
GO:0098609
GO:0098772
HMNXSV003029143
HMNXSV003056955
Hs.81972.0.A1_3p_a_at
Hs.81972.1.A1_3p_a_at
ILMN_1701967
ILMN_1721022
ILMN_1812570
PH_hs_0030190
TC01006381.hg
U73377_at
Participates
as a member of
p-3Y SHC1-2, p-3Y SHC1-3 [cytosol] (Homo sapiens)
p-3Y-SHC1 [cytosol] (Homo sapiens)
p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol] (Homo sapiens)
as an output of
Phosphorylation of SHC by SYK kinase (Homo sapiens)
as an input of
Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)
as a component of
p-SHC1:GRB2:SOS [cytosol] (Homo sapiens)
Other forms of this molecule
SHC1-2 [plasma membrane]
p-S29,3Y-SHC1-2 [cytosol]
SHC1-2 [cytosol]
p-Y317-SHC1-2 [cytosol]
p-Y239,Y240,Y317-SHC1-2 [plasma membrane]
Inferred From
p-Y239,Y240,Y313-Shc1 [cytosol]
(Mus musculus)
Inferred To
phospho-Shc1 [cytosol]
(Mus musculus)
phospho-Shc1 [cytosol]
(Rattus norvegicus)
phospho-p-Y239,Y240,Y317-SHC1-2 [cytosol]
(Canis familiaris)
phospho-p-Y239,Y240,Y317-SHC1-2 [cytosol]
(Danio rerio)
phospho-SHC1 [cytosol]
(Bos taurus)
phospho-SHC1 [cytosol]
(Gallus gallus)
phospho-SHC1 [cytosol]
(Sus scrofa)
phospho-Shc [cytosol]
(Drosophila melanogaster)
Ghost homologue of p-Y239,Y240,Y317-SHC1-2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 239
Coordinate
239
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 240
Coordinate
240
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 317
Coordinate
317
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001123513.1
,
NP_892113.4
,
NP_001189788.1
,
NP_001123512.1
,
NP_003020.2
OpenTargets
ENSG00000160691
HPA
ENSG00000160691-SHC1
GeneCards
P29353
ZINC - Substances
SHC1_HUMAN
ZINC target
P29353
Ensembl
ENSP00000357430
,
ENST00000448116
,
ENSG00000160691
,
ENSP00000357438
,
ENST00000368450
,
ENSP00000357435
,
ENST00000368453
,
ENST00000368445
,
ENSP00000401303
PRO
P29353
Pharos - Targets
P29353
ZINC - Predictions - Purchasable
SHC1_HUMAN
PDB
1TCE
,
1SHC
,
5CZI
,
4XWX
,
1MIL
,
2L1C
,
4JMH
,
6DM4
,
1N3H
,
1OY2
,
1QG1
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.976
44
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.974
31
UniProt:P62994 Grb2
3
Grb2 [cytosol]
(R-RNO-55929)
Grb2 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-74686)
0.822
5
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.821
16
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.816
6
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.813
8
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.77
5
UniProt:P21860 ERBB3
0.762
7
UniProt:O95782 AP2A1
5
AP2A1 [endolysosome membrane]
(R-HSA-6784829)
AP2A1 [endocytic vesicle membrane]
(R-HSA-416641)
AP2A1 [plasma membrane]
(R-HSA-177494)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138449)
AP2A1 [cytosol]
(R-HSA-182143)
0.643
5
UniProt:O94973 AP2A2
6
AP2A2(1-939) [endolysosome membrane]
(R-HSA-6784819)
AP2A2(1-939) [secretory granule membrane]
(R-HSA-6800412)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-HSA-6800414)
AP2A2(1-939) [plasma membrane]
(R-HSA-177502)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138448)
AP2A2(1-939) [cytosol]
(R-HSA-182155)
0.643
4
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.643
5
UniProt:Q16832 DDR2
1
DDR2 [plasma membrane]
(R-HSA-211419)
0.632
3
UniProt:Q15303 ERBB4
0.609
6
UniProt:Q12774 ARHGEF5
1
ARHGEF5 [cytosol]
(R-HSA-8873909)
0.597
4
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.589
6
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.573
2
UniProt:P35968 KDR
4
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.564
2
UniProt:P29353 SHC1
5
SHC1 [cytosol]
(R-HSA-74680)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
0.564
2
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.564
2
UniProt:Q13137 CACO2
0.553
3
UniProt:P16573
11
Ceacam1 [extracellular region]
(R-RNO-8941137-3)
Ceacam1 [plasma membrane]
(R-RNO-8940816-3)
Ceacam1 [tertiary granule membrane]
(R-RNO-6800953)
Ceacam1 [specific granule membrane]
(R-RNO-6806076-3)
Ceacam1 [specific granule membrane]
(R-RNO-6799528)
Ceacam1 [plasma membrane]
(R-RNO-197706-3)
Ceacam1 [plasma membrane]
(R-RNO-197701)
Ceacam1 [extracellular region]
(R-RNO-8870747-3)
Ceacam1 [extracellular region]
(R-RNO-8870766-3)
Ceacam1 [extracellular region]
(R-RNO-8870757-3)
Ceacam1 [extracellular region]
(R-RNO-8870759-3)
0.544
3
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.544
2
UniProt:Q9UQC2 GAB2
5
p-Y643-GAB2 [cytosol]
(R-HSA-9677149)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
p-Y-GAB2 [cytosol]
(R-HSA-912529)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
GAB2 [cytosol]
(R-HSA-508239)
0.544
2
UniProt:P26954 IL3B2
0.544
4
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
0.527
3
UniProt:Q05655 PRKCD
12
PRKCD(1-676) [nucleoplasm]
(R-HSA-450606)
PRKCD(330-676) [extracellular region]
(R-HSA-6806199)
PRKCD(1-329) [extracellular region]
(R-HSA-6806226)
PRKCD(1-329) [azurophil granule lumen]
(R-HSA-6799219)
PRKCD(330-676) [azurophil granule lumen]
(R-HSA-6799221)
p-T507-PRKCD [cytosol]
(R-HSA-5218746)
PRKCD(330-676) [cytosol]
(R-HSA-212551)
PRKCD(1-329) [cytosol]
(R-HSA-212547)
p-T507,S645,S664-PRKCD [cytosol]
(R-HSA-5218734)
active p-T507,S645,S664-PRKCD [plasma membrane]
(R-HSA-5607635)
p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
(R-HSA-198294)
PRKCD [cytosol]
(R-HSA-58200)
0.527
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.527
2
UniProt:P32927 CSF2RB
6
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
0.527
4
UniProt:Q8TF42 UBS3B
0.527
3
UniProt:Q38SD2 LRRK1
0.527
3
UniProt:Q93008 USP9X
1
USP9X [cytosol]
(R-HSA-870499)
0.527
3
UniProt:P03495 NS1
0.508
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.483
3
UniProt:Q02763 TEK
2
TEK [plasma membrane]
(R-HSA-197755)
p-5Y,S1119-TEK [plasma membrane]
(R-HSA-204772)
0.462
2
UniProt:Q08345-1 DDR1
0.462
4
UniProt:A9UF07 A9UF07
0.462
4
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.462
2
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