Reactome | GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol]

GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol]

Stable Identifier

R-HSA-9713455

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GRIP and coiled-coil domain-containing protein 2, GCC2_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        GCC2(1-1204)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
        
        GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
28741662	Molecular breakdown: a comprehensive view of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer Choi, YL, Lee, SH, Shin, HT, Kim, M, Oh, DY, Lee, MS, Sung, M, Noh, KW, Kim, YJ, Park, WY, Shim, YM, Lee, SE, An, S, Zo, JI, Song, JY, Han, J, Jung, K, Kim, J	J Pathol	2017

External Reference Information

External Reference

UniProt:Q8IWJ2 GCC2

Gene Names

GCC2, KIAA0336, RANBP2L4

Chain

chain:1-1684

Reference Genes

BioGPS Gene:9648 GCC2

COSMIC (genes):GCC2 GCC2

CTD Gene:9648 GCC2

dbSNP Gene:9648 GCC2

ENSEMBL:ENSG00000135968 GCC2

HGNC:23218 GCC2

Monarch:9648 GCC2

NCBI Gene:9648 GCC2

OMIM:612711 GCC2

UCSC:Q8IWJ2 GCC2

Reference Transcript

Other Identifiers

11719350_a_at

11719351_s_at

11719352_x_at

11719353_s_at

11740762_s_at

11752004_s_at

16884062

202832_3p_at

202832_PM_at

202832_at

210676_PM_x_at

231383_PM_at

231383_at

2492318

2492319

2492320

2492336

2492337

2492338

2492339

2498768

2498769

2498770

2498771

2498983

2498984

2498985

2498987

2498988

2498990

2498991

2498992

2498993

2498994

2498995

2498996

2498997

2498998

2498999

2499000

2499001

2499002

2499003

2499004

2499006

2499007

2499008

2499009

2499010

2499011

2499012

2499013

2499014

2499015

2499016

2499017

2499018

2499019

2499020

2499021

2499024

2499025

2499026

2499032

2499038

2499040

2499042

2499653

2499654

2499655

2499656

2499657

2499659

2499661

2499662

2499689

2499698

2499701

2563411

2563412

2563419

2563420

2563421

2563422

2563423

2563424

2563425

2569086

2569090

2569091

2569092

2569093

2570467

2570468

2570469

2570471

2570474

2570475

2570476

2570477

2570478

2570479

2570524

2571276

2571278

2571281

2571284

2571291

2571292

2571293

2571294

2571295

2571296

2571297

3337075

41174_at

64362_at

70427_at

75512_r_at

75525_at

76559_at

8044236

9648

A_23_P384085

A_24_P290502

A_24_P85942

A_24_P917021

A_33_P3247933

GE511880

GE88839

GO:0005515

GO:0005654

GO:0005737

GO:0005794

GO:0005802

GO:0005829

GO:0006622

GO:0006886

GO:0007010

GO:0015031

GO:0016020

GO:0016192

GO:0031023

GO:0031267

GO:0034067

GO:0034453

GO:0034499

GO:0042147

GO:0042802

GO:0043226

GO:0043227

GO:0043229

GO:0070861

GO:0071955

GO:0090161

HMNXSV003051806

Hs.128818.0.A1_3p_at

ILMN_1654195

ILMN_1678831

ILMN_2408730

PH_hs_0028085

TC02000666.hg

TC02003486.hg

g7662061_3p_at

g7662061_3p_s_at

g7662061_3p_x_at

Participates

as a component of

GCC2(1-1204)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

GCC2 [cytosol]

GCC2(1-1204)-ALK(1059-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1059 to 1620 at 1205 from UniProt:Q9UM73 ALK

Coordinate

1205

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1358

Coordinate

1358

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
non-small cell lung carcinoma	DOID:3908	Non-small cell lung cancer (disorder), NSCLC, NSCLC

Cross References

ENSEMBL

ENST00000482325, ENSP00000419969, ENST00000309863, ENSP00000307939

OpenTargets

ENSG00000135968

HPA

ENSG00000135968-GCC2

PRO

Q8IWJ2

Pharos - Targets

Q8IWJ2

GlyGen

Q8IWJ2

PDB

3BBP

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20340 RAB6A	8	RAB6A [endoplasmic reticulum membrane] (R-HSA-8849253) RAB6A [trans-Golgi network membrane] (R-HSA-6810981) GGC-RAB6A [trans-Golgi network membrane] (R-HSA-8876079) GGC-RAB6A [cytosol] (R-HSA-8874052) RAB6A [cytosol] (R-HSA-6810979) RAB6A [plasma membrane] (R-HSA-6804981) RAB6A [secretory granule membrane] (R-HSA-6804970) RAB6A [Golgi membrane] (R-HSA-1604442)	0.618	4
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.558	3
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.527	3
UniProt:A1L4H1 SSC5D	1	SSC5D [extracellular region] (R-HSA-8878615)	0.527	2
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.527	3
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.527	3
UniProt:P18509 ADCYAP1	4	ADCYAP1(132-158) [extracellular region] (R-HSA-420144) ADCYAP1(82-129) [extracellular region] (R-HSA-420254) ADCYAP1(132-169) [extracellular region] (R-HSA-420282) ADCYAP1(2-742) [Golgi membrane] (R-HSA-187679)	0.527	2