Reactome | CHN1 [cytosol]

CHN1 [cytosol]

Stable Identifier

R-HSA-2980571

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

N-chimaerin, CHIN_HUMAN, Alpha-chimaerin, Chimaerin-alpha, ARHGAP2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P15882 CHN1

Gene Names

CHN1, ARHGAP2, CHN

Chain

initiator methionine:1, chain:2-459

Reference Genes

BioGPS Gene:1123 CHN1

COSMIC (genes):CHN1 CHN1

CTD Gene:1123 CHN1

dbSNP Gene:1123 CHN1

ENSEMBL:ENSG00000128656 CHN1

HGNC:1943 CHN1

KEGG Gene (Homo sapiens):1123 CHN1

Monarch:1123 CHN1

NCBI Gene:1123 CHN1

OMIM:118423 CHN1

UCSC:P15882 CHN1

Reference Transcript

Other Identifiers

0000510368

1123

11741135_s_at

11741136_x_at

11741137_a_at

212624_s_at

2587971

2587972

2587973

2587974

2587975

2587976

2587977

2587980

2587984

2587985

2587986

2587987

2587994

2588000

2588001

2588002

2588003

2588004

2588009

2588010

2588017

2588018

2588020

2588021

2588029

2588030

2588031

2588032

40512_at

8056890

A_23_P79482

A_33_P3325723

GE59753

GE86778

GO:0000902

GO:0003674

GO:0005096

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0007165

GO:0007399

GO:0008045

GO:0008150

GO:0030154

GO:0030234

GO:0035556

GO:0040011

GO:0043087

GO:0043167

GO:0043547

GO:0046872

GO:0046875

GO:0048013

GO:0048856

GO:0050770

GO:0051056

HMNXSV003011774

Hs.169965.1.S1_3p_a_at

ILMN_1678493

ILMN_1679638

PH_hs_0018468

TC02002544.hg

TC02004703.hg

X51408_at

Participates

as a candidate of

CDC42 GAPs [cytosol] (Homo sapiens)

as a member of

RAC1 GAPs [cytosol] (Homo sapiens)

Inferred To

chn1 [cytosol] (Danio rerio)

chn1 [cytosol] (Xenopus tropicalis)

gacM [cytosol] (Dictyostelium discoideum)

CHN1 [cytosol] (Canis familiaris)

CHN1 [cytosol] (Gallus gallus)

CHN1 [cytosol] (Sus scrofa)

chin-1 [cytosol] (Caenorhabditis elegans)

Chn1 [cytosol] (Mus musculus)

Chn1 [cytosol] (Rattus norvegicus)

RhoGAP5A [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001020372.2, NP_001193531.1, NP_001813.1

OpenTargets

ENSG00000128656

HPA

ENSG00000128656-CHN1

GeneCards

P15882

Ensembl

ENST00000295497, ENSP00000295497, ENSP00000386470, ENST00000409900, ENSG00000128656, ENST00000409156, ENSP00000386741

PRO

P15882

Pharos - Targets

P15882

Orphanet

18228

HMDB Protein

HMDBP10961

PDB

2OSA, 3CXL

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.886	16
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.556	3

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