Reactome | p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]

p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]

Stable Identifier

R-HSA-9619872

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho(S227,T365,S369,S386,T577,T737)-Ribosomal protein S6 kinase alpha 3, p-S227,T365,S369,S386,T577,T737-RSK2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P51812 RPS6KA3

Gene Names

RPS6KA3, ISPK1, MAPKAPK1B, RSK2

Chain

chain:1-740

Reference Genes

BioGPS Gene:6197 RPS6KA3

COSMIC (genes):RPS6KA3 RPS6KA3

CTD Gene:6197 RPS6KA3

dbSNP Gene:6197 RPS6KA3

ENSEMBL:ENSG00000177189 RPS6KA3

ENSEMBL_homo_sapiens_GENE:ENSG00000177189.14 RPS6KA3

HGNC:10432 RPS6KA3

KEGG Gene (Homo sapiens):6197 RPS6KA3

Monarch:6197 RPS6KA3

NCBI Gene:6197 RPS6KA3

OMIM:300075 RPS6KA3

UCSC:P51812 RPS6KA3

Reference Transcript

RefSeq:NM_004586.2 RPS6KA3

Other Identifiers

11742811_at

11742812_a_at

17109716

203843_PM_at

203843_at

226335_PM_at

226335_at

33229_at

4002174

4002175

4002176

4002177

4002178

4002179

4002180

4002181

4002182

4002184

4002189

4002190

4002191

4002192

4002194

4002196

4002199

4002201

4002202

4002203

4002205

4002211

4002212

4002214

4002218

4002219

4002221

4002225

4002226

4002230

4002239

4002240

4002241

46959_at

51906_at

6197

8171762

865_at

A_32_P517749

GE79413

GE87121

GO:0000166

GO:0000287

GO:0001501

GO:0002224

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004711

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0007049

GO:0007165

GO:0007268

GO:0007417

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019901

GO:0023052

GO:0030154

GO:0030307

GO:0032496

GO:0035556

GO:0036211

GO:0043027

GO:0043066

GO:0043154

GO:0043226

GO:0043555

GO:0045202

GO:0045597

GO:0045944

GO:0046872

GO:0048856

GO:0098542

GO:0098772

GO:0106310

GO:0140096

HMNXSV003041000

HMNXSV003046361

Hs.173965.0.S2_3p_at

Hs.188361.0.S1_3p_at

ILMN_1652736

ILMN_1770822

ILMN_1806294

PH_hs_0022897

TC0X000911.hg

U08316_at

Participates

as a member of

p-S221,T359.S363,S380,T573,T732-RSK [cytosol] (Homo sapiens)

Other forms of this molecule

RPS6KA3 [nucleoplasm]

p-4S,T231,T365-RPS6KA3 [nucleoplasm]

RPS6KA3 [cytosol]

p-T365,S369,T577-RPS6KA3 [cytosol]

p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol]

p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm]

Inferred To

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Bos taurus)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Caenorhabditis elegans)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Canis familiaris)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Dictyostelium discoideum)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Drosophila melanogaster)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Mus musculus)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Rattus norvegicus)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Saccharomyces cerevisiae)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Schizosaccharomyces pombe)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Sus scrofa)

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (Xenopus tropicalis)

phospho-RPS6KA3 [cytosol] (Gallus gallus)

Modified Residues

Name

O-phospho-L-serine at 227

Coordinate

227

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 365

Coordinate

365

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 369

Coordinate

369

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 386

Coordinate

386

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 577

Coordinate

577

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 737

Coordinate

737

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_004577.1

ZINC - World Drugs

KS6A3_HUMAN

Guide to Pharmacology - Targets

1528

OpenTargets

ENSG00000177189

ZINC - FDA approved

KS6A3_HUMAN

ZINC - Substances

KS6A3_HUMAN

ZINC - Biogenic

KS6A3_HUMAN

ZINC target

P51812

PRO

P51812

PDB

4NW5, 4JG8, 5D9L, 4NW6, 4D9T, 8XEY, 8XFY, 4JG6, 4D9U, 5D9K, 4NUS, 8EQ5, 4JG7, 7OPO

ZINC - Investigational

KS6A3_HUMAN

GeneCards

P51812

HPA

ENSG00000177189-RPS6KA3

Ensembl

ENSP00000368884, ENSG00000177189, ENST00000379565

Pharos - Targets

P51812

Orphanet

15231

ZINC - Predictions - Purchasable

KS6A3_HUMAN

HMDB Protein

HMDBP01443

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.878	12
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.788	6
UniProt:P21802 FGFR2	20	FGFR2 IIIa TM [extracellular region] (R-HSA-8851703) FGFR2 [plasma membrane] (R-HSA-2023840) FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853137) FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853154) FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853123) FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853158) FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853150) FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853153) FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853139) FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853159) FGFR2 N549H [plasma membrane] (R-HSA-2033296) FGFR2 N549K [plasma membrane] (R-HSA-1637910) FGFR2 K660N [plasma membrane] (R-HSA-1637905) FGFR2 K660M [plasma membrane] (R-HSA-1637902) FGFR2 K660E [plasma membrane] (R-HSA-1637900) FGFR2 S267P [plasma membrane] (R-HSA-1637920) FGFR2 L764Hfs*4 [plasma membrane] (R-HSA-1637908) FGFR2 W290C [plasma membrane] (R-HSA-1637929) p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853134) p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853146)	0.745	5
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.671	4
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.615	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	3
UniProt:Q12849 GRSF1	2	GRSF1 [mitochondrial matrix] (R-HSA-9837006) GRSF1 [cytosol] (R-HSA-192689)	0.527	2
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.527	2

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