Reactome | KEL [plasma membrane]

KEL [plasma membrane]

Stable Identifier

R-HSA-5694121

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Kell blood group glycoprotein ecNumber3.4.24.-/ecNumber cdAntigenNameCD238/cdAntigenName, KELL_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        XK:KEL:Zn2+ cleaves EDN3 (Homo sapiens)
        
        XK:KEL:Zn2+ [plasma membrane] (Homo sapiens)
        
        KEL [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23276 KEL

Gene Names

KEL

Chain

chain:1-732

Reference Genes

BioGPS Gene:3792 KEL

COSMIC (genes):KEL KEL

CTD Gene:3792 KEL

dbSNP Gene:3792 KEL

ENSEMBL:ENSG00000197993 KEL

HGNC:6308 KEL

KEGG:hsa:3792 KEL

Monarch:3792 KEL

NCBI Gene:3792 KEL

OMIM:613883 KEL

UCSC:P23276 KEL

Reference Transcript

RefSeq:NM_000420.2 KEL

Other Identifiers

11726225_at

17063892

206077_PM_at

206077_at

3077169

3077170

3077171

3077172

3077173

3077174

3077175

3077176

3077177

3077178

3077179

3077180

3077181

3077182

3077183

3077185

3077186

3077187

3077188

3077192

3077193

3077194

3077195

3077196

3077197

3077198

3077199

3077200

3077201

3077202

3077203

3077205

3077206

3077209

3792

38197_at

8143534

A_23_P252758

GE79533

GO:0003013

GO:0003824

GO:0004222

GO:0005515

GO:0005654

GO:0005794

GO:0005829

GO:0005886

GO:0006508

GO:0006874

GO:0008237

GO:0008361

GO:0010961

GO:0016020

GO:0016485

GO:0016787

GO:0031133

GO:0042310

GO:0042552

GO:0043226

GO:0046872

GO:0048741

GO:0048856

GO:0051604

GO:0051649

GO:0055085

GO:0071805

GO:0140096

GO:1901380

HMNXSV003013100

ILMN_1738468

M64934_at

PH_hs_0019711

TC07001965.hg

g4557690_3p_at

Participates

as a component of

XK:KEL:Zn2+ [plasma membrane] (Homo sapiens)

Inferred To

Kel [plasma membrane] (Rattus norvegicus)

KEL [plasma membrane] (Canis familiaris)

KEL [plasma membrane] (Gallus gallus)

KEL [plasma membrane] (Mus musculus)

KEL [plasma membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000477793, ENST00000615381, ENSP00000347409, ENST00000355265

OpenTargets

ENSG00000197993

HPA

ENSG00000197993-KEL

PRO

P23276

Pharos - Targets

P23276

GlyGen

P23276

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:P01031 C5	7	C5a [extracellular region] (R-HSA-173677) C5 beta chain [extracellular region] (R-HSA-173675) C5 alpha chain [extracellular region] (R-HSA-173673) C5b alpha' [extracellular region] (R-HSA-173672) C5a-desArg [extracellular region] (R-HSA-8852798) C5aT [extracellular region] (R-HSA-8852711) C5(965-1676) [extracellular region] (R-HSA-8852713)	0.556	3