Reactome | ITGAV(31-1048) [phagocytic vesicle]

ITGAV(31-1048) [phagocytic vesicle]

Stable Identifier

R-HSA-1236773

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagocytic vesicle

Synonyms

Integrin alpha-V, CD51 antigen

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing-Cross presentation (Homo sapiens)
      - Cross-presentation of particulate exogenous antigens (phagosomes) (Homo sapiens)
        
        Engulfment of particulate antigen into phagocytic vesicle (Homo sapiens)
        
        DC receptors recognizing apoptotic cells [phagocytic vesicle] (Homo sapiens)
        
        alphaVbeta5 [phagocytic vesicle] (Homo sapiens)
        
        ITGAV(31-1048) [phagocytic vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06756 ITGAV

Gene Names

ITGAV, MSK8, VNRA, VTNR

Chain

signal peptide:1-30, chain:31-1048, chain:31-889, chain:891-1048

Reference Genes

BioGPS Gene:3685 ITGAV

COSMIC (genes):ITGAV ITGAV

CTD Gene:3685 ITGAV

dbSNP Gene:3685 ITGAV

ENSEMBL:ENSG00000138448 ITGAV

ENSEMBL_homo_sapiens_GENE:ENSG00000138448.13 ITGAV

HGNC:6150 ITGAV

KEGG Gene (Homo sapiens):3685 ITGAV

Monarch:3685 ITGAV

NCBI Gene:3685 ITGAV

OMIM:193210 ITGAV

UCSC:P06756 ITGAV

Reference Transcript

Other Identifiers

11716299_a_at

11716300_x_at

11716301_a_at

11752333_a_at

11757515_s_at

16888512

202351_PM_at

202351_at

2032_s_at

2519230

2519231

2519232

2519234

2519235

2519238

2519241

2519242

2519246

2519249

2519250

2519252

2519254

2519255

2519256

2519257

2519261

2519262

2519263

2519264

2519265

2519267

2519268

2519270

2519271

2519274

2519275

2519276

2519279

2519280

2519281

2519285

2519286

2519288

2519289

2519290

2519291

257_at

3685

39071_at

8046861

A_23_P381992

A_23_P50907

GE57833

GO:0001525

GO:0001568

GO:0001570

GO:0001618

GO:0001846

GO:0001968

GO:0002020

GO:0005080

GO:0005102

GO:0005178

GO:0005215

GO:0005245

GO:0005515

GO:0005576

GO:0005615

GO:0005829

GO:0005886

GO:0005925

GO:0007155

GO:0007160

GO:0007204

GO:0007229

GO:0008284

GO:0008305

GO:0009897

GO:0009986

GO:0010745

GO:0010888

GO:0012501

GO:0015026

GO:0016020

GO:0016192

GO:0016477

GO:0017134

GO:0019960

GO:0023052

GO:0030154

GO:0030335

GO:0031258

GO:0031410

GO:0031527

GO:0031528

GO:0031589

GO:0031994

GO:0032369

GO:0032587

GO:0033627

GO:0033690

GO:0034113

GO:0034446

GO:0034682

GO:0034683

GO:0034684

GO:0034685

GO:0034686

GO:0035313

GO:0035579

GO:0035866

GO:0035867

GO:0035868

GO:0035987

GO:0038027

GO:0038132

GO:0042060

GO:0043226

GO:0043277

GO:0045335

GO:0045785

GO:0046718

GO:0046872

GO:0048856

GO:0048870

GO:0050431

GO:0050748

GO:0050764

GO:0050840

GO:0050919

GO:0051057

GO:0055085

GO:0060089

GO:0070062

GO:0070161

GO:0070371

GO:0070588

GO:0071604

GO:0085017

GO:0097192

GO:0098609

GO:1901388

GO:1902533

GO:1905598

GO:1990430

GO:2000536

GO:2001237

HMNXSV003037331

Hs.295726.0.S2_3p_at

ILMN_2169439

M14648_at

TC02001100.hg

Participates

as a component of

alphaVbeta5 [phagocytic vesicle] (Homo sapiens)

Other forms of this molecule

ITGAV(31-1048) [specific granule membrane]

ITGAV(31-1048) [plasma membrane]

Inferred To

itgav [phagocytic vesicle] (Danio rerio)

itgav [phagocytic vesicle] (Xenopus tropicalis)

ITGAV [phagocytic vesicle] (Bos taurus)

ITGAV [phagocytic vesicle] (Canis familiaris)

ITGAV [phagocytic vesicle] (Sus scrofa)

ITGAV(31-1048) [phagocytic vesicle] (Gallus gallus)

ITGAV(31-1048) [phagocytic vesicle] (Mus musculus)

Itgav [phagocytic vesicle] (Rattus norvegicus)

pat-2 [phagocytic vesicle] (Caenorhabditis elegans)

if [phagocytic vesicle] (Drosophila melanogaster)

Cross References

RefSeq

NP_002201.1, NP_001138471.1, NP_001138472.1

Guide to Pharmacology - Targets

2453

OpenTargets

ENSG00000138448

ZINC - Substances

ITAV_HUMAN

ZINC target

P06756

PRO

P06756

PDB

4G1M, 4MMY, 8TCG, 4UM9, 6UJB, 6AVR, 5NEM, 1L5G, 5FFG, 4MMZ, 6MSU, 6UJC, 5NER, 6AVU, 5FFO, 5NET, 3IJE, 6DJP, 5NEU, 6NAJ, 1M1X, 6MK0, 4O02, 1JV2, 8IJ5, 4G1E, 1U8C, 4UM8, 6OM1, 6AVQ, 8TCF, 6MSL, 6OM2, 4MMX, 7Y1T, 6UJA

ZINC - Investigational

ITAV_HUMAN

HPA

ENSG00000138448-ITGAV

GeneCards

P06756

Ensembl

ENSP00000404291, ENST00000433736, ENSP00000364042, ENST00000374907, ENST00000261023, ENSP00000261023, ENSG00000138448

Pharos - Targets

P06756

ZINC - Predictions - Purchasable

ITAV_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.743	4
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.488	2