Reactome | PDE7A [cytosol]

PDE7A [cytosol]

Stable Identifier

R-HSA-418525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 7A, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, PDE7A_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP PDEs [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic AMP-selective [cytosol] (Homo sapiens)
        
        PDE7 [cytosol] (Homo sapiens)
        
        PDE7A [cytosol] (Homo sapiens)

General

cAMP selective hydrolase

External Reference Information

External Reference

UniProt:Q13946 PDE7A

Gene Names

PDE7A

Chain

chain:1-482

Reference Genes

BioGPS Gene:5150 PDE7A

COSMIC (genes):PDE7A PDE7A

CTD Gene:5150 PDE7A

dbSNP Gene:5150 PDE7A

ENSEMBL:ENSG00000205268 PDE7A

ENSEMBL_homo_sapiens_GENE:ENSG00000205268.11 PDE7A

HGNC:8791 PDE7A

KEGG Gene (Homo sapiens):5150 PDE7A

Monarch:5150 PDE7A

NCBI Gene:5150 PDE7A

OMIM:171885 PDE7A

UCSC:Q13946 PDE7A

Reference Transcript

Other Identifiers

11720870_a_at

11720871_s_at

11732430_at

1552343_3p_s_at

1552343_PM_s_at

1552343_s_at

17077774

223358_PM_s_at

223358_s_at

224046_PM_s_at

224046_s_at

230444_PM_at

230444_at

3138455

3138456

3138457

3138459

3138461

3138463

3138465

3138466

3138467

3138468

3138469

3138470

3138471

3138472

3138473

3138474

3138475

3138477

3138478

3138479

3138480

3138482

3138483

3138484

3138486

3138487

3138496

3138498

3138499

3138502

3138508

3138511

3138513

3138514

3138515

3138524

3138525

3138526

3138527

3138528

47990_at

5150

78530_at

8151074

A_23_P123478

A_24_P360529

A_32_P137382

A_33_P3301955

GE839734

GO:0003824

GO:0004114

GO:0004115

GO:0005737

GO:0005829

GO:0006198

GO:0007165

GO:0008081

GO:0016787

GO:0019933

GO:0023052

GO:0046872

GO:0055086

GO:1901135

HMNXSV003016928

HMNXSV003019810

Hs.150395.0.S1_3p_a_at

Hs.177708.0.A1_3p_at

Hs2.406325.1.S1_3p_s_at

ILMN_2262444

ILMN_2278819

ILMN_2379675

PH_hs_0024009

TC08001282.hg

TC08002356.hg

U67932_s_at

g2306763_3p_a_at

Participates

as a member of

PDE7 [cytosol] (Homo sapiens)

Inferred To

Homologues of PDE7A [cytosol] (Dictyostelium discoideum)

Homologues of PDE7A [cytosol] (Plasmodium falciparum)

PDE7A [cytosol] (Canis familiaris)

PDE7A [cytosol] (Dictyostelium discoideum)

PDE7A [cytosol] (Gallus gallus)

PDE7A [cytosol] (Mus musculus)

PDE7A [cytosol] (Plasmodium falciparum)

PDE7A [cytosol] (Rattus norvegicus)

PDE7A [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001229247.1, NP_002594.1, XP_011515842.1

ZINC - World Drugs

PDE7A_HUMAN

Guide to Pharmacology - Targets

1305

OpenTargets

ENSG00000205268

ZINC - FDA approved

PDE7A_HUMAN

ZINC - Substances

PDE7A_HUMAN

ZINC target

Q13946

PRO

Q13946

PDB

4Y2B, 1ZKL, 4PM0, 3G3N

GeneCards

Q13946

HPA

ENSG00000205268-PDE7A

Ensembl

ENSP00000385632, ENST00000396642, ENSP00000368730, ENSP00000379881, ENST00000401827, ENST00000379419, ENSG00000205268

Pharos - Targets

Q13946

ZINC - Predictions - Purchasable

PDE7A_HUMAN

HMDB Protein

HMDBP00590