Reactome | PRKAR1A [cytosol]

PRKAR1A [cytosol]

Stable Identifier

R-HSA-57836

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-dependent protein kinase type I-alpha regulatory chain, Tissue- specific extinguisher-1, TSE1

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Metabolism (Homo sapiens)

- Integration of energy metabolism (Homo sapiens)
  - Glucagon signaling in metabolic regulation (Homo sapiens)
    - PKA activation in glucagon signalling (Homo sapiens)
      - cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
  - Regulation of insulin secretion (Homo sapiens)
    - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
      - PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)
        
        PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        cAMP:PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
        
        cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR1A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10644 PRKAR1A

Gene Names

PRKAR1A, PKR1, PRKAR1, TSE1

Chain

chain:1-381

Reference Genes

BioGPS Gene:5573 PRKAR1A

COSMIC (genes):PRKAR1A PRKAR1A

CTD Gene:5573 PRKAR1A

dbSNP Gene:5573 PRKAR1A

ENSEMBL:ENSG00000108946 PRKAR1A

ENSEMBL:ENSG00000108946.16 PRKAR1A

HGNC:9388 PRKAR1A

KEGG Gene (Homo sapiens):5573 PRKAR1A

Monarch:5573 PRKAR1A

NCBI Gene:5573 PRKAR1A

OMIM:188830 PRKAR1A

UCSC:P10644 PRKAR1A

Reference Transcript

Other Identifiers

11722007_a_at

11722008_a_at

11753791_s_at

16837326

200603_PM_at

200603_at

200604_PM_s_at

200604_s_at

200605_PM_s_at

200605_s_at

226_at

227_g_at

2346669

3732886

3732887

3732888

3732889

3732890

3732891

3732892

3732895

3732896

3732897

3732898

3732901

3732902

3732904

3732905

3732908

3732911

3732913

3732915

3732916

3732918

3732919

3732920

3732921

3732922

3732923

3732926

41768_at

54729_at

5573

60224_at

8009457

A_14_P136947

A_23_P433753

A_24_P245322

A_24_P356592

GE61216

GE87724

GO:0000166

GO:0001707

GO:0001772

GO:0001932

GO:0002376

GO:0003824

GO:0004862

GO:0005515

GO:0005737

GO:0005768

GO:0005771

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0005930

GO:0005952

GO:0006351

GO:0006355

GO:0006357

GO:0006469

GO:0007010

GO:0007155

GO:0007189

GO:0007507

GO:0008603

GO:0010629

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019904

GO:0023052

GO:0030154

GO:0030552

GO:0031410

GO:0031588

GO:0031594

GO:0031625

GO:0032024

GO:0032991

GO:0034236

GO:0035556

GO:0036211

GO:0043226

GO:0044853

GO:0045202

GO:0045214

GO:0046007

GO:0048856

GO:0060038

GO:0071377

GO:0097224

GO:0097546

GO:0098772

GO:0098978

GO:2000480

HMNXSV003015567

HMNXSV003028511

HMNXSV003035036

Hs.183037.0.A3_3p_at

ILMN_1738632

ILMN_2277077

ILMN_2389590

M33336_at

TC17000804.hg

TC17002330.hg

TC17002331.hg

g1526988_3p_a_at

g4506062_3p_a_at

Participates

as a member of

PKA regulatory subunit [cytosol] (Homo sapiens)

Other forms of this molecule

PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol]

PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol]

PRKAR1A [ciliary base]

Inferred To

Homologues of PRKAR1A [cytosol] (Danio rerio)

PRKAR1A [cytosol] (Bos taurus)

PRKAR1A [cytosol] (Caenorhabditis elegans)

PRKAR1A [cytosol] (Canis familiaris)

PRKAR1A [cytosol] (Danio rerio)

PRKAR1A [cytosol] (Dictyostelium discoideum)

PRKAR1A [cytosol] (Drosophila melanogaster)

PRKAR1A [cytosol] (Gallus gallus)

PRKAR1A [cytosol] (Mus musculus)

PRKAR1A [cytosol] (Rattus norvegicus)

PRKAR1A [cytosol] (Sus scrofa)

PRKAR1A [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011523286.1, NP_001263218.1, NP_001263219.1, NP_001265362.1, NP_997637.1, NP_002725.1, XP_011523285.1, XP_011523287.1, NP_997636.1

Guide to Pharmacology - Targets

1472

OpenTargets

ENSG00000108946

HPA

ENSG00000108946-PRKAR1A

GeneCards

P10644

Ensembl

ENST00000585427, ENST00000586397, ENST00000585981, ENSG00000108946, ENST00000589017, ENSP00000376475, ENSP00000445625, ENST00000589480, ENSP00000351410, ENST00000358598, ENST00000392711, ENST00000589228, ENST00000588188, ENST00000588178, ENSP00000467311, ENSP00000465013, ENSP00000465445, ENSP00000468106, ENSP00000466459, ENST00000536854, ENSP00000466649, ENSP00000464715, ENSP00000464977

PRO

P10644

Pharos - Targets

P10644

Orphanet

15139

HMDB Protein

HMDBP02560

PDB

5KJZ, 5KJY, 5KJX

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.952	14
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.671	4
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.623	5
UniProt:O60285 NUAK1	2	p-T211-NUAK1 [nucleoplasm] (R-HSA-3222011) NUAK1 [nucleoplasm] (R-HSA-3222004)	0.564	2
UniProt:P24588 AKAP5	2	AKAP5 [plasma membrane] (R-HSA-381669) AKAP5 [cytosol] (R-HSA-416331)	0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.547	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.527	2
UniProt:Q01105 SET	1	SET [nucleoplasm] (R-HSA-451201)	0.524	2
UniProt:P35250 RFC2	1	RFC2 [nucleoplasm] (R-HSA-68433)	0.524	7

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