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PRKAR1A [cytosol]
Stable Identifier
R-HSA-57836
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cAMP-dependent protein kinase type I-alpha regulatory chain, Tissue- specific extinguisher-1, TSE1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Homo sapiens)
Dual-specific AKAPs:PKA tetramer [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Glucagon signaling in metabolic regulation (Homo sapiens)
PKA activation in glucagon signalling (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)
PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA activation (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA activation (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
GPER1 signaling (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Aquaporin-mediated transport (Homo sapiens)
Vasopressin regulates renal water homeostasis via Aquaporins (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
PKA regulatory subunit [cytosol] (Homo sapiens)
PRKAR1A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10644 PRKAR1A
Gene Names
PRKAR1A, PKR1, PRKAR1, TSE1
Chain
chain:1-381
Reference Genes
BioGPS Gene:5573 PRKAR1A
COSMIC (genes):PRKAR1A PRKAR1A
CTD Gene:5573 PRKAR1A
dbSNP Gene:5573 PRKAR1A
ENSEMBL:ENSG00000108946 PRKAR1A
HGNC:9388 PRKAR1A
KEGG Gene (Homo sapiens):5573 PRKAR1A
Monarch:5573 PRKAR1A
NCBI Gene:5573 PRKAR1A
OMIM:188830 PRKAR1A
UCSC:P10644 PRKAR1A
Reference Transcript
RefSeq:XM_011524983.2 PRKAR1A
RefSeq:NM_212471.2 PRKAR1A
RefSeq:XM_011524985.2 PRKAR1A
RefSeq:NM_001276290.1 PRKAR1A
RefSeq:NM_212472.2 PRKAR1A
RefSeq:NM_001276289.1 PRKAR1A
RefSeq:NM_002734.4 PRKAR1A
RefSeq:XM_011524984.2 PRKAR1A
RefSeq:NM_001278433.1 PRKAR1A
Other Identifiers
0001050072
11722007_a_at
11722008_a_at
11753791_s_at
16837326
200603_PM_at
200603_at
200604_PM_s_at
200604_s_at
200605_PM_s_at
200605_s_at
226_at
227_g_at
2346669
3732886
3732887
3732888
3732889
3732895
3732896
3732897
3732898
3732901
3732902
3732904
3732905
3732908
3732911
3732913
3732915
3732916
3732918
3732919
3732920
3732921
3732922
3732926
41768_at
54729_at
5573
60224_at
8009457
A_14_P136947
A_23_P433753
A_24_P356592
GE61216
GE87724
GO:0000166
GO:0001707
GO:0001772
GO:0001932
GO:0002376
GO:0003674
GO:0004862
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005768
GO:0005771
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0005930
GO:0005952
GO:0006357
GO:0006464
GO:0006469
GO:0007010
GO:0007155
GO:0007165
GO:0007507
GO:0008150
GO:0008283
GO:0008603
GO:0009058
GO:0009790
GO:0010629
GO:0016020
GO:0016301
GO:0016310
GO:0019899
GO:0019904
GO:0022607
GO:0030154
GO:0030234
GO:0030552
GO:0031410
GO:0031588
GO:0031594
GO:0031625
GO:0032991
GO:0034236
GO:0034641
GO:0035556
GO:0040007
GO:0043167
GO:0043226
GO:0044853
GO:0045202
GO:0045214
GO:0046007
GO:0048646
GO:0048856
GO:0060038
GO:0097224
GO:0097546
GO:0098978
GO:2000480
HMNXSV003028511
HMNXSV003035036
Hs.183037.0.A3_3p_at
ILMN_1738632
ILMN_2277077
ILMN_2389590
M33336_at
TC17000804.hg
TC17002330.hg
TC17002331.hg
g1526988_3p_a_at
g4506062_3p_a_at
Participates
as a member of
PKA regulatory subunit [cytosol] (Homo sapiens)
Other forms of this molecule
PRKAR1A(1-183)-p-7Y ALK(1058-1620) fusion [cytosol]
PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol]
PRKAR1A [ciliary base]
Inferred To
prkar1a [cytosol]
(Xenopus tropicalis)
prkar1ab [cytosol]
(Danio rerio)
Prkar1a [cytosol]
(Mus musculus)
Prkar1a [cytosol]
(Rattus norvegicus)
kin-2 [cytosol]
(Caenorhabditis elegans)
Homologues of PRKAR1A [cytosol]
(Danio rerio)
Pka-R1 [cytosol]
(Drosophila melanogaster)
pkaR [cytosol]
(Dictyostelium discoideum)
PRKAR1A [cytosol]
(Bos taurus)
PRKAR1A [cytosol]
(Canis familiaris)
PRKAR1A [cytosol]
(Gallus gallus)
PRKAR1A [cytosol]
(Sus scrofa)
prkar1aa [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001265362.1
,
XP_011523287.1
,
NP_002725.1
,
NP_997636.1
,
NP_001263218.1
,
XP_011523286.1
,
XP_011523285.1
,
NP_001263219.1
,
NP_997637.1
Guide to Pharmacology - Targets
1472
OpenTargets
ENSG00000108946
HPA
ENSG00000108946-PRKAR1A
GeneCards
P10644
Ensembl
ENSP00000351410
,
ENSP00000464977
,
ENST00000392711
,
ENST00000586397
,
ENST00000589228
,
ENST00000588188
,
ENSP00000468106
,
ENST00000358598
,
ENSP00000466459
,
ENSP00000376475
,
ENSP00000445625
,
ENSG00000108946
,
ENST00000536854
PRO
P10644
Pharos - Targets
P10644
Orphanet
15139
HMDB Protein
HMDBP02560
PDB
5KJZ
,
5KJX
,
5KJY
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17612 PRKACA
3
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.952
14
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.671
4
UniProt:O60285 NUAK1
2
p-T211-NUAK1 [nucleoplasm]
(R-HSA-3222011)
NUAK1 [nucleoplasm]
(R-HSA-3222004)
0.564
2
UniProt:P24588 AKAP5
2
AKAP5 [plasma membrane]
(R-HSA-381669)
AKAP5 [cytosol]
(R-HSA-416331)
0.556
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.547
2
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.527
2
UniProt:P35250 RFC2
1
RFC2 [nucleoplasm]
(R-HSA-68433)
0.524
7
UniProt:Q01105 SET
1
SET [nucleoplasm]
(R-HSA-451201)
0.524
2
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