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Rps6 [cytosol]
Stable Identifier
R-MMU-9633488
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
40S ribosomal protein S6, RS6_MOUSE
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Mus musculus)
Nonsense-Mediated Decay (NMD) (Mus musculus)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
rRNA processing (Mus musculus)
rRNA processing in the nucleus and cytosol (Mus musculus)
Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Mus musculus)
Protein hydroxylation (Mus musculus)
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Translation (Mus musculus)
Eukaryotic Translation Initiation (Mus musculus)
Cap-dependent Translation Initiation (Mus musculus)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Mus musculus)
Translation initiation complex formation (Mus musculus)
Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Formation of a pool of free 40S subunits (Mus musculus)
Release of 40S and 60S subunits from the 80S ribosome (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
eIF3 and eIF1A bind to the 40S subunit (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
40S:eIF3:eIF1A [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Formation of the ternary complex, and subsequently, the 43S complex (Mus musculus)
Formation of the 43S pre-initiation complex (Mus musculus)
40S:eIF3:eIF1A [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Mus musculus)
The 60S subunit joins the translation initiation complex (Mus musculus)
40S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
eIF2:GTP is hydrolyzed, eIFs are released (Mus musculus)
40S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
eIF5B:GTP is hydrolyzed and released (Mus musculus)
80S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Ribosomal scanning and start codon recognition (Mus musculus)
Ribosomal scanning (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Start codon recognition (Mus musculus)
48S complex [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
L13a-mediated translational silencing of Ceruloplasmin expression (Mus musculus)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
43S complex [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Ribosome-associated quality control (Mus musculus)
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (Mus musculus)
ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released (Mus musculus)
ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide (Mus musculus)
ABCE1:ADP:40S ribosomal subunit [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide (Mus musculus)
80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Mus musculus)
RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide (Mus musculus)
K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
K63polyUb-80S ribosome [cytosol] (Mus musculus)
K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] (Mus musculus)
K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
K63polyUb-80S ribosome [cytosol] (Mus musculus)
K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Mus musculus)
K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
K63polyUb-80S ribosome [cytosol] (Mus musculus)
K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Mus musculus)
80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
SRP-dependent cotranslational protein targeting to membrane (Mus musculus)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)
SRP:polypeptide+signal:ribosome [cytosol] (Mus musculus)
ribosome:mRNA:polypeptide+signal [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
ribosome:mRNA:polypeptide+signal [cytosol] (Mus musculus)
80S ribosome [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
Rps6 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MTOR signalling (Mus musculus)
mTORC1-mediated signalling (Mus musculus)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Mus musculus)
Rps6 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P62754 Rps6
Gene Names
Rps6
Chain
chain:1-249
Reference Genes
BioGPS Gene:20104 Rps6
KEGG:mmu:20104 Rps6
Monarch:20104 Rps6
NCBI Gene:20104 Rps6
UCSC:P62754 Rps6
Other Identifiers
101577_at
10363699
10421571
10424823
10446821
10483806
10514233
10573821
10604904
1416141_a_at
1416142_at
1434377_x_at
1454620_x_at
1455693_x_at
17386692
17427003
20104
4383212
4430801
4447002
4643345
4738132
4824771
4866288
4884509
4970665
4978385
4980592
5163137
5196702
5238174
5246357
5406748
5417599
5487069
5528275
A_51_P344734
A_55_P2008567
GO:0000082
GO:0000278
GO:0001890
GO:0002181
GO:0002309
GO:0002376
GO:0003735
GO:0005198
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0005840
GO:0006364
GO:0006412
GO:0006924
GO:0007369
GO:0008284
GO:0022414
GO:0022605
GO:0022627
GO:0030154
GO:0030425
GO:0032040
GO:0033077
GO:0042254
GO:0042274
GO:0042593
GO:0043066
GO:0048471
GO:0048821
GO:0048856
GO:1990904
ILMN_1232951
ILMN_1248932
ILMN_2893077
mMC025786
Participates
as a component of
K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
40S ribosomal subunit [cytosol] (Mus musculus)
40S ribosomal complex [cytosol] (Mus musculus)
as an input of
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Mus musculus)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Mus musculus)
Other forms of this molecule
Rps6 [nucleoplasm]
Rps6 [cytosol]
phospho-Rps6 [cytosol]
Inferred From
RPS6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033122.1
ENSEMBL
ENSMUST00000102814
,
ENSMUSP00000099878
,
ENSMUSG00000028495
PRO
P62754
GlyGen
P62754
MGI
98159
PDB
7CPU
,
7LS1
,
7LS2
,
7CPV
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63073 Eif4e
1
Eif4e [cytosol]
(R-MMU-9817689)
0.499
2
UniProt:Q9JLN9
2
MTOR [nucleoplasm]
(R-MMU-5083674)
MTOR [cytosol]
(R-MMU-165662)
0.462
3
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