Reactome | p-S246,S287-PRKRA [cytosol]

p-S246,S287-PRKRA [cytosol]

Stable Identifier

R-HSA-9834791

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75569 PRKRA

Gene Names

PRKRA, PACT, RAX, HSD-14, HSD14

Chain

chain:1-313

Reference Genes

BioGPS Gene:8575 PRKRA

COSMIC (genes):PRKRA PRKRA

CTD Gene:8575 PRKRA

dbSNP Gene:8575 PRKRA

ENSEMBL:ENSG00000180228 PRKRA

ENSEMBL_homo_sapiens_GENE:ENSG00000180228.14 PRKRA

HGNC:9438 PRKRA

KEGG Gene (Homo sapiens):8575 PRKRA

Monarch:8575 PRKRA

NCBI Gene:8575 PRKRA

OMIM:603424 PRKRA

UCSC:O75569 PRKRA

Reference Transcript

Other Identifiers

11722156_a_at

11743076_a_at

16905570

209139_PM_s_at

209139_s_at

2589218

2589219

2589220

2589221

2589222

2589225

2589231

2589234

2589237

2589243

2589247

2589248

2589249

2589250

2589251

2589252

32205_at

8057034

8575

GE54683

GO:0002376

GO:0003723

GO:0003725

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006955

GO:0008047

GO:0008285

GO:0009615

GO:0012501

GO:0016020

GO:0016442

GO:0019899

GO:0023052

GO:0030422

GO:0031047

GO:0031054

GO:0034599

GO:0035196

GO:0035197

GO:0042473

GO:0042474

GO:0042802

GO:0042803

GO:0043226

GO:0043583

GO:0048471

GO:0048705

GO:0048856

GO:0050821

GO:0065003

GO:0070578

GO:0070883

GO:0070920

GO:0070922

GO:0098772

GO:2001244

HMNXSV003027759

ILMN_1758474

PH_hs_0029214

g4927415_3p_a_at

Participates

as a component of

p-PRKRA dimer [cytosol] (Homo sapiens)

Other forms of this molecule

PRKRA [cytosol]

Inferred To

phospho-Prkra [cytosol] (Mus musculus)

phospho-Prkra [cytosol] (Rattus norvegicus)

phospho-prkra [cytosol] (Danio rerio)

phospho-prkra [cytosol] (Xenopus tropicalis)

phospho-loqs [cytosol] (Drosophila melanogaster)

phospho-PRKRA [cytosol] (Bos taurus)

phospho-PRKRA [cytosol] (Canis familiaris)

phospho-PRKRA [cytosol] (Sus scrofa)

phospho-rde-4 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 246

Coordinate

246

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 287

Coordinate

287

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001132990.1, NP_001132989.1, NP_003681.1

OpenTargets

ENSG00000180228

GeneCards

O75569

HPA

ENSG00000180228-PRKRA

Ensembl

ENSG00000180228, ENSP00000393883, ENSP00000430604, ENST00000325748, ENST00000487082, ENSP00000318176, ENST00000432031

PRO

O75569

Pharos - Targets

O75569

Orphanet

18740

PDB

2DIX

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15633 TARBP2	2	TARBP2 [cytosol] (R-HSA-203864) p-TARBP2 [cytosol] (R-HSA-9835348)	0.919	15
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.8	6
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.8	9
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.778	8
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.688	5
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.667	3
UniProt:Q12906 ILF3	3	p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [cytosol] (R-HSA-450564) ILF3 [nucleoplasm] (R-HSA-9760401)	0.615	3
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.564	5
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:P78563 ADARB1	1	ADARB1 [nucleoplasm] (R-HSA-62915)	0.547	2
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.537	6
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	3

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