Reactome | NIP7 [nucleoplasm]

NIP7 [nucleoplasm]

Stable Identifier

R-HSA-6797236

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

60S ribosome subunit biogenesis protein NIP7 homolog, NIP7_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y221 NIP7

Gene Names

NIP7, CGI-37, HSPC031, HSPC180, OK/SW-cl.76, OK/SW-cl.78

Chain

chain:1-180

Reference Genes

BioGPS Gene:51388 NIP7

COSMIC (genes):NIP7 NIP7

CTD Gene:51388 NIP7

dbSNP Gene:51388 NIP7

ENSEMBL:ENSG00000132603 NIP7

HGNC:24328 NIP7

Monarch:51388 NIP7

NCBI Gene:51388 NIP7

OMIM:619204 NIP7

UCSC:Q9Y221 NIP7

Reference Transcript

Other Identifiers

11727849_a_at

11727850_x_at

16820584

219031_PM_s_at

219031_s_at

223397_PM_s_at

223397_s_at

3666687

3666688

3666689

3666690

3666691

3666692

3666693

3666694

3666695

3666696

3666697

3666698

3666699

3666700

51388

65502_r_at

7996934

88358_r_at

A_14_P128153

A_14_P129948

A_23_P54834

A_33_P3283906

GE62623

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005829

GO:0030687

GO:0042254

GO:0042255

GO:0042273

GO:0043226

HMNXSV003043224

ILMN_1704305

PH_hs_0026540

TC16000568.hg

g6841579_3p_a_at

g7705436_3p_a_at

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Inferred To

NIP7 [nucleoplasm] (Bos taurus)

NIP7 [nucleoplasm] (Canis familiaris)

NIP7 [nucleoplasm] (Sus scrofa)

Nip7 [nucleoplasm] (Mus musculus)

Nip7 [nucleoplasm] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000254941, ENST00000254940, ENSP00000254941, ENSP00000254940

OpenTargets

ENSG00000132603

HPA

ENSG00000132603-NIP7

PRO

Q9Y221

Pharos - Targets

Q9Y221

PDB

8FKT, 8FKV, 8FKX, 8FKW, 8FKU, 1SQW, 8FKY, 1T5Y

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46087 NOP2	1	NOP2 [nucleoplasm] (R-HSA-6790922)	0.669	5
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	3
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2

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