Reactome | rps6 [cytosol]

rps6 [cytosol]

Stable Identifier

R-DRE-72381

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPS6, Q6DHL6

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)
- rRNA processing (Danio rerio)
  - rRNA processing in the nucleus and cytosol (Danio rerio)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Danio rerio)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps6 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6DHL6

Gene Names

rps6

Reference Genes

BioGPS Gene:445028 rps6

ENSEMBL:ENSDARG00000019778

KEGG:dre:445028 rps6

Monarch:445028 rps6

NCBI Gene:445028 rps6

UCSC:Q6DHL6 rps6

Other Identifiers

12921017

12921019

12921021

12921023

12921025

12921027

12921045

12921051

12921053

12921055

12921921

12921923

12921925

12921927

12921929

12921931

12921949

12921955

12921957

12921959

12939063

12939065

12939067

12939069

12939071

12939073

12939091

12939097

12939099

12939101

12939869

12939871

12939873

12939875

12939877

12939879

12939897

12939903

12939905

12939907

12957383

445028

A_15_P109803

A_15_P535422

A_15_P574687

A_15_P711051

A_15_P771216

CJ011299

CJ011300

CJ011301

CJ011302

CJ012635

DRER02980

Dr.18282.3.S2_at

ENSDART00000023336

ENSDART00000023336_1

ENSDART00000023336_2

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:1990904

GT_Spec_NM_001003728.1_210375

MADDr01001307

NM_001003728

Participates

as a component of

as an input of

Other forms of this molecule

rps6 [nucleoplasm]

rps6 [cytosol]

phospho-rps6 [cytosol]

Inferred From

RPS6 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001003728.1

ENSEMBL

ENSDART00000023336, ENSDARP00000011148, ENSDARG00000019778

ZFIN

ZDB-GENE-040801-8

PDB

7OYB, 7OYA

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