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TPH1 [cytosol]
Stable Identifier
R-HSA-976250
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tryptophan 5-hydroxylase 1, TPH1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Serotonin and melatonin biosynthesis (Homo sapiens)
Tryptophan is hydroxylated (Homo sapiens)
TPH:Fe++ [cytosol] (Homo sapiens)
TPH [cytosol] (Homo sapiens)
TPH1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
TPH1 gene expression (Homo sapiens)
TPH1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17752 TPH1
Gene Names
TPH1, TPH, TPRH, TRPH
Chain
chain:1-444
Reference Genes
BioGPS Gene:7166 TPH1
COSMIC (genes):TPH1 TPH1
CTD Gene:7166 TPH1
dbSNP Gene:7166 TPH1
ENSEMBL:ENSG00000129167 TPH1
ENSEMBL_homo_sapiens_GENE:ENSG00000129167.10 TPH1
HGNC:12008 TPH1
KEGG Gene (Homo sapiens):7166 TPH1
Monarch:7166 TPH1
NCBI Gene:7166 TPH1
OMIM:191060 TPH1
UCSC:P17752 TPH1
Reference Transcript
RefSeq:NM_004179.2 TPH1
Other Identifiers
11740862_a_at
11740863_at
11757229_a_at
16736405
214601_PM_at
214601_at
231626_PM_at
231626_at
3365198
3365200
3365202
3365204
3365205
3365206
3365207
3365208
3365209
3365210
3365211
3365212
3365213
3365214
3365215
3365216
3365217
3365218
37879_r_at
7166
74393_at
7946946
A_23_P150595
GE54540
GE890019
GE902895
GO:0002576
GO:0003824
GO:0004497
GO:0004510
GO:0005506
GO:0005515
GO:0005737
GO:0005829
GO:0006520
GO:0007623
GO:0009072
GO:0016192
GO:0016491
GO:0016714
GO:0030154
GO:0030279
GO:0035902
GO:0042427
GO:0043005
GO:0045600
GO:0046849
GO:0046872
GO:0048856
GO:0060749
GO:1900046
HMNXSV003056844
Hs.129056.0.A1_3p_at
Hs.144563.0.A2_3p_at
ILMN_1679115
ILMN_1817252
L29306_s_at
PH_hs_0024002
TC11003436.hg
Participates
as an output of
TPH1 gene expression (Homo sapiens)
as a member of
TPH [cytosol] (Homo sapiens)
Inferred To
TPH1 [cytosol]
(Bos taurus)
TPH1 [cytosol]
(Caenorhabditis elegans)
TPH1 [cytosol]
(Canis familiaris)
TPH1 [cytosol]
(Danio rerio)
TPH1 [cytosol]
(Dictyostelium discoideum)
TPH1 [cytosol]
(Drosophila melanogaster)
TPH1 [cytosol]
(Gallus gallus)
TPH1 [cytosol]
(Mus musculus)
TPH1 [cytosol]
(Rattus norvegicus)
TPH1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_004170.1
Guide to Pharmacology - Targets
1241
OpenTargets
ENSG00000129167
ZINC - Substances
TPH1_HUMAN
ZINC target
P17752
PRO
P17752
PDB
7ZIH
,
7ZII
,
7ZIG
,
3HFB
,
7ZIF
,
5J6D
,
7ZIK
,
3HF8
,
7ZIJ
,
5TPG
,
5L01
,
3HF6
,
1MLW
GeneCards
P17752
HPA
ENSG00000129167-TPH1
Ensembl
ENSP00000508368
,
ENSP00000250018
,
ENST00000250018
,
ENSG00000129167
,
ENST00000682019
Pharos - Targets
P17752
Orphanet
24994
ZINC - Predictions - Purchasable
TPH1_HUMAN
HMDB Protein
HMDBP00469
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43586 PSTPIP1
1
PSTPIP1 [cytosol]
(R-HSA-879220)
0.556
3
UniProt:Q96IK1-2 Q96IK12
0.556
3
UniProt:O95789-4 ZMYM6
0.556
3
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.556
3
UniProt:Q9H8Y8 GORASP2
2
p-T222,T225-GORASP2 [Golgi membrane]
(R-HSA-2422965)
GORASP2 [Golgi membrane]
(R-HSA-2422385)
0.556
5
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