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PIK3C3 [phagocytic vesicle membrane]
Stable Identifier
R-HSA-6798182
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
phagocytic vesicle membrane
Synonyms
PI3K class III Catalytic subunit, VPS34
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
PIK3C3:PIK3R4 phosphorylates PI to PI3P (Homo sapiens)
PIK3C3:PIK3R4 [phagocytic vesicle membrane] (Homo sapiens)
PIK3C3 [phagocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NEB9 PIK3C3
Gene Names
PIK3C3, VPS34
Chain
chain:1-887
Reference Genes
BioGPS Gene:5289 PIK3C3
COSMIC (genes):PIK3C3 PIK3C3
CTD Gene:5289 PIK3C3
dbSNP Gene:5289 PIK3C3
ENSEMBL:ENSG00000078142 PIK3C3
HGNC:8974 PIK3C3
KEGG:hsa:5289 PIK3C3
Monarch:5289 PIK3C3
NCBI Gene:5289 PIK3C3
OMIM:602609 PIK3C3
UCSC:Q8NEB9 PIK3C3
Reference Transcript
RefSeq:NM_002647.3 PIK3C3
Other Identifiers
11755049_a_at
1569272_PM_at
1569272_at
16852098
204297_PM_at
204297_at
215394_PM_at
215394_at
229705_PM_at
229705_at
232086_PM_at
232086_at
239300_PM_at
239300_at
35665_at
3786078
3786079
3786080
3786081
3786082
3786083
3786084
3786085
3786094
3786096
3786097
3786098
3786099
3786101
3786102
3786103
3786105
3786108
3786109
3786112
3786113
3786114
3786115
3786117
3786118
3786120
3786121
3786124
3786127
3786129
3786130
3786131
3786134
3786135
3786137
3786139
3786140
3786141
3786146
3786147
3786148
3786149
3786150
3786151
3786152
3786153
3786154
3786155
3786156
3786189
5289
61096_at
8021015
A_14_P111156
A_14_P117012
A_14_P123049
A_23_P164536
A_24_P288116
GE60410
GE665503
GE88078
GO:0000045
GO:0000407
GO:0003824
GO:0004672
GO:0005515
GO:0005524
GO:0005737
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005777
GO:0005829
GO:0005930
GO:0006497
GO:0006622
GO:0006629
GO:0006886
GO:0006897
GO:0006914
GO:0009267
GO:0010506
GO:0016020
GO:0016192
GO:0016236
GO:0016241
GO:0016301
GO:0016303
GO:0016740
GO:0030242
GO:0030496
GO:0030670
GO:0031410
GO:0032465
GO:0034271
GO:0034272
GO:0034497
GO:0035032
GO:0036092
GO:0042149
GO:0043226
GO:0044754
GO:0044829
GO:0045022
GO:0045335
GO:0046854
GO:0048015
GO:0048488
GO:0051301
GO:0052742
GO:0097352
GO:0098794
GO:0098830
GO:0098845
GO:0098978
GO:0098982
GO:0140096
HMNXSV003018200
Hs.193041.0.A1_3p_at
Hs.239340.0.S1_3p_at
Hs.239340.0.S1_3p_x_at
Hs.306638.0.S1_3p_at
Hs.3734.0.A1_3p_at
Hs2.407259.1.S1_3p_at
ILMN_1687896
PH_hs_0012896
PH_hs_0025089
TC18000156.hg
TC18000689.hg
Z46973_at
g4505800_3p_at
Participates
as a component of
PIK3C3:PIK3R4 [phagocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
PIK3C3 [cytosol]
Inferred To
PIK3C3 [phagocytic vesicle membrane]
(Bos taurus)
PIK3C3 [phagocytic vesicle membrane]
(Canis familiaris)
PIK3C3 [phagocytic vesicle membrane]
(Gallus gallus)
PIK3C3 [phagocytic vesicle membrane]
(Plasmodium falciparum)
PIK3C3 [phagocytic vesicle membrane]
(Sus scrofa)
vps-34 [phagocytic vesicle membrane]
(Caenorhabditis elegans)
vps34 [phagocytic vesicle membrane]
(Schizosaccharomyces pombe)
Pik3c3 [phagocytic vesicle membrane]
(Mus musculus)
Pik3c3 [phagocytic vesicle membrane]
(Rattus norvegicus)
Pi3K59F [phagocytic vesicle membrane]
(Drosophila melanogaster)
pikE [phagocytic vesicle membrane]
(Dictyostelium discoideum)
VPS34 [phagocytic vesicle membrane]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_002638.2
Guide to Pharmacology - Targets
2152
OpenTargets
ENSG00000078142
ENSEMBL
ENSP00000262039
,
ENST00000262039
,
ENSG00000078142
ZINC - Substances
PK3C3_HUMAN
ZINC target
Q8NEB9
PRO
Q8NEB9
PDB
9C82
,
7RSV
,
6HOG
,
5ANL
,
3IHY
,
6HOH
,
4UWH
,
3LS8
,
4UWK
,
4OYS
,
6I3U
,
4UWF
,
7RSJ
,
7RSP
,
7BL1
,
4UWG
,
5ENN
,
4PH4
,
8SOR
,
4UWL
,
6YKG
,
8RXR
ZINC - Investigational
PK3C3_HUMAN
IntEnz
2.7.1.137
HPA
ENSG00000078142-PIK3C3
GeneCards
PIK3C3
Pharos - Targets
Q8NEB9
ZINC - Predictions - Purchasable
PK3C3_HUMAN
HMDB Protein
HMDBP03992
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14457 BECN1
4
BECN1 [cytosol]
(R-HSA-1632841)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
0.97
43
UniProt:Q9P2Y5 UVRAG
2
UVRAG [cytosol]
(R-HSA-5668884)
UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9730510)
0.935
25
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