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GRIA1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-5689460
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
CNIH2,3 bind GRIA1 (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Loss of SAR1B GTPase (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
CNIH2,3 bind GRIA1 (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Inner coat assembly and cargo binding (Homo sapiens)
COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42261 GRIA1
Gene Names
GRIA1, GLUH1, GLUR1, GLUR1
Chain
signal peptide:1-18, chain:19-906
Reference Genes
BioGPS Gene:2890 GRIA1
COSMIC (genes):GRIA1 GRIA1
CTD Gene:2890 GRIA1
dbSNP Gene:2890 GRIA1
ENSEMBL:ENSG00000155511 GRIA1
ENSEMBL_homo_sapiens_GENE:ENSG00000155511.19 GRIA1
HGNC:4571 GRIA1
KEGG Gene (Homo sapiens):2890 GRIA1
Monarch:2890 GRIA1
NCBI Gene:2890 GRIA1
OMIM:138248 GRIA1
UCSC:P42261 GRIA1
Reference Transcript
RefSeq:NM_001258021.1 GRIA1
RefSeq:NM_001258023.1 GRIA1
RefSeq:NM_000827.3 GRIA1
RefSeq:NM_001258019.1 GRIA1
RefSeq:NM_001258022.1 GRIA1
RefSeq:NM_001114183.1 GRIA1
Other Identifiers
11739499_a_at
11745982_a_at
11745983_x_at
11748236_a_at
16991296
209793_PM_at
209793_at
211520_PM_s_at
211520_s_at
2836266
2836267
2836268
2836270
2836314
2836315
2836316
2836317
2836322
2836323
2836324
2836326
2836327
2836331
2836332
2836333
2836349
2836350
2836351
2836367
2836368
2836375
2836376
2836377
2836383
2836384
2836385
2836386
2836387
2836388
2890
36853_at
36854_s_at
36855_r_at
8109383
A_23_P303072
GE58235
GO:0001540
GO:0001919
GO:0001965
GO:0004970
GO:0004971
GO:0005215
GO:0005216
GO:0005515
GO:0005576
GO:0005768
GO:0005769
GO:0005783
GO:0005789
GO:0005886
GO:0005911
GO:0006811
GO:0007165
GO:0007215
GO:0007268
GO:0007416
GO:0007616
GO:0008021
GO:0008066
GO:0008092
GO:0008179
GO:0008328
GO:0009410
GO:0009636
GO:0009986
GO:0010226
GO:0010628
GO:0012507
GO:0014069
GO:0014070
GO:0015276
GO:0016020
GO:0016192
GO:0019228
GO:0019865
GO:0019901
GO:0019904
GO:0021510
GO:0021987
GO:0022824
GO:0023052
GO:0030165
GO:0030425
GO:0030666
GO:0030672
GO:0031090
GO:0031267
GO:0031410
GO:0031489
GO:0031594
GO:0031623
GO:0031681
GO:0031698
GO:0031901
GO:0032279
GO:0032281
GO:0032355
GO:0032590
GO:0032591
GO:0032809
GO:0032991
GO:0033116
GO:0034220
GO:0034330
GO:0035235
GO:0035249
GO:0035254
GO:0036477
GO:0038023
GO:0042220
GO:0042734
GO:0042802
GO:0042995
GO:0043005
GO:0043025
GO:0043197
GO:0043198
GO:0043226
GO:0043434
GO:0044297
GO:0044308
GO:0044309
GO:0045202
GO:0045211
GO:0045838
GO:0046685
GO:0048167
GO:0048787
GO:0048856
GO:0050804
GO:0050806
GO:0050877
GO:0051018
GO:0051602
GO:0055037
GO:0055038
GO:0055065
GO:0055085
GO:0060076
GO:0060078
GO:0060089
GO:0060292
GO:0060992
GO:0071230
GO:0071242
GO:0071359
GO:0071363
GO:0071375
GO:0071407
GO:0071418
GO:0097060
GO:0097110
GO:0098793
GO:0098794
GO:0098839
GO:0098978
GO:0099505
GO:0099507
GO:0099544
GO:0099566
GO:0099583
GO:1904315
GO:1990416
HMNXSV003051400
Hs.7117.1.A2_3p_at
ILMN_2203299
M64752_at
M81886_s_at
PH_hs_0021980
TC05000849.hg
Z70220_at
g183280_3p_a_at
Participates
as an input of
CNIH2,3 bind GRIA1 (Homo sapiens)
as a component of
CNIH2,3:GRIA1 [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GRIA1 [ER to Golgi transport vesicle membrane]
GRIA1 [endocytic vesicle membrane]
p-S849-GRIA1 [plasma membrane]
GRIA1 [plasma membrane]
Inferred To
Ir76b [endoplasmic reticulum membrane]
(Drosophila melanogaster)
glr-7 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
DmelCG11155 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
GRIA1 [endoplasmic reticulum membrane]
(Bos taurus)
GRIA1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
GRIA1 [endoplasmic reticulum membrane]
(Canis familiaris)
GRIA1 [endoplasmic reticulum membrane]
(Gallus gallus)
GRIA1 [endoplasmic reticulum membrane]
(Mus musculus)
GRIA1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
GRIA1 [endoplasmic reticulum membrane]
(Sus scrofa)
glr-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
gria1a [endoplasmic reticulum membrane]
(Danio rerio)
glr-2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
glr-6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
glr-5 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of GRIA1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of GRIA1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
glr-4 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
gria1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Ekar [endoplasmic reticulum membrane]
(Drosophila melanogaster)
GluRIB [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Ir21a [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Ir8a [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Ir25a [endoplasmic reticulum membrane]
(Drosophila melanogaster)
GluRIA [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Ir93a [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001244952.1
,
NP_001107655.1
,
NP_001244950.1
,
NP_000818.2
,
NP_001244951.1
,
NP_001244948.1
Guide to Pharmacology - Targets
444
OpenTargets
ENSG00000155511
HPA
ENSG00000155511-GRIA1
GeneCards
P42261
Ensembl
ENSP00000427920
,
ENST00000518142
,
ENSP00000428994
,
ENSP00000285900
,
ENSP00000339343
,
ENSG00000155511
,
ENST00000340592
,
ENST00000518783
,
ENSP00000415569
,
ENST00000285900
,
ENST00000448073
,
ENST00000521843
,
ENSP00000427864
ZINC target
P42261
PRO
P42261
Pharos - Targets
P42261
Orphanet
28185
PDB
6X5Q
HMDB Protein
HMDBP02795
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6XD76 ASCL4
0.556
3
UniProt:Q15907 RAB11B
3
RAB11B [recycling endosome membrane]
(R-HSA-8854762)
GGC-RAB11B [cytosol]
(R-HSA-8873766)
RAB11B [cytosol]
(R-HSA-8873671)
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
3
UniProt:Q9UNY5 ZN232
0.556
3
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.556
3
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