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AFG3L2 [mitochondrial inner membrane]
Stable Identifier
R-HSA-8949650
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
AFG3-like protein 2 ecNumber evidence="6"3.4.24.-/ecNumber, AFG32_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
AFG3L2 binds mitochondrial inner membrane proteins (Homo sapiens)
AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 binds mitochondrial matrix proteins (Homo sapiens)
AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:substrate protein (mitochondrial matrix) [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 degrades mitochondrial inner membrane proteins (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 degrades mitochondrial matrix proteins (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:substrate protein (mitochondrial matrix) [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ hexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:SPG7 binds SMDT1 (EMRE) (Homo sapiens)
AFG3L2:SPG7:SMDT1 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+:SPG7:Zn2+ heterohexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+:SPG7:Zn2+ heterohexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:SPG7 degrades SMDT1 (EMRE) (Homo sapiens)
AFG3L2:SPG7:SMDT1 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+:SPG7:Zn2+ heterohexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+:SPG7:Zn2+ heterohexamer [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Mitochondrial calcium ion transport (Homo sapiens)
Processing of SMDT1 (Homo sapiens)
AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] (Homo sapiens)
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
AFG3L2 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4W6 AFG3L2
Gene Names
AFG3L2
Chain
transit peptide:1-38, propeptide:39-66, chain:67-797
Reference Genes
BioGPS Gene:10939 AFG3L2
COSMIC (genes):AFG3L2 AFG3L2
CTD Gene:10939 AFG3L2
dbSNP Gene:10939 AFG3L2
ENSEMBL:ENSG00000141385 AFG3L2
HGNC:315 AFG3L2
KEGG:hsa:10939 AFG3L2
Monarch:10939 AFG3L2
NCBI Gene:10939 AFG3L2
OMIM:604581 AFG3L2
UCSC:Q9Y4W6 AFG3L2
Reference Transcript
RefSeq:NM_006796.2 AFG3L2
Other Identifiers
10939
11754692_a_at
1557820_PM_at
1557820_at
16853996
202486_PM_at
202486_at
232919_PM_at
232919_at
3133584
3133593
3133601
34315_at
3799416
3799417
3799418
3799419
3799420
3799423
3799424
3799425
3799426
3799427
3799428
3799429
3799430
3799432
3799433
3799434
3799435
3799436
3799437
3799438
3799439
3799440
3799441
3799442
3799443
3799444
3799448
3799449
3799450
3799451
3799452
3799455
3799456
3799457
3799458
8022342
GE555799
GE60343
GE83965
GO:0003824
GO:0004176
GO:0004222
GO:0005515
GO:0005524
GO:0005739
GO:0005743
GO:0005745
GO:0006508
GO:0007005
GO:0007409
GO:0007528
GO:0008053
GO:0008233
GO:0008237
GO:0008270
GO:0016020
GO:0016485
GO:0016540
GO:0016787
GO:0016887
GO:0021675
GO:0030163
GO:0033619
GO:0034330
GO:0034982
GO:0036444
GO:0040014
GO:0042407
GO:0042552
GO:0043226
GO:0046872
GO:0048856
GO:0051082
GO:0051560
GO:0051604
GO:0055001
GO:0055085
GO:0060013
GO:0061024
GO:0072753
GO:0110097
GO:0140096
GO:0140657
GO:0141164
HMNXSV003033170
Hs.287495.0.S1_3p_at
Hs2.416822.1.A1_3p_at
ILMN_2066124
PH_hs_0025528
TC18000373.hg
g5802969_3p_at
Participates
as a component of
AFG3L2:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
Inferred To
AFG3L2 [mitochondrial inner membrane]
(Bos taurus)
AFG3L2 [mitochondrial inner membrane]
(Caenorhabditis elegans)
AFG3L2 [mitochondrial inner membrane]
(Canis familiaris)
AFG3L2 [mitochondrial inner membrane]
(Dictyostelium discoideum)
AFG3L2 [mitochondrial inner membrane]
(Drosophila melanogaster)
AFG3L2 [mitochondrial inner membrane]
(Gallus gallus)
AFG3L2 [mitochondrial inner membrane]
(Mus musculus)
AFG3L2 [mitochondrial inner membrane]
(Plasmodium falciparum)
AFG3L2 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
AFG3L2 [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
AFG3L2 [mitochondrial inner membrane]
(Sus scrofa)
afg3l2 [mitochondrial inner membrane]
(Danio rerio)
afg3l2 [mitochondrial inner membrane]
(Xenopus tropicalis)
rcaA [mitochondrial inner membrane]
(Dictyostelium discoideum)
Afg3l2 [mitochondrial inner membrane]
(Drosophila melanogaster)
Afg3l2 [mitochondrial inner membrane]
(Rattus norvegicus)
Homologues of AFG3L2 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Homologues of AFG3L2 [mitochondrial inner membrane]
(Dictyostelium discoideum)
Homologues of AFG3L2 [mitochondrial inner membrane]
(Drosophila melanogaster)
Homologues of AFG3L2 [mitochondrial inner membrane]
(Plasmodium falciparum)
Homologues of AFG3L2 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Cross References
ENSEMBL
ENST00000269143
,
ENSP00000269143
,
ENSG00000141385
OpenTargets
ENSG00000141385
GeneCards
AFG3L2
HPA
ENSG00000141385-AFG3L2
PRO
Q9Y4W6
Pharos - Targets
Q9Y4W6
GlyGen
Q9Y4W6
Orphanet
AFG3L2
PDB
2LNA
,
6NYY
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q14457 BECN1
4
BECN1 [cytosol]
(R-HSA-1632841)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
0.483
3
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