Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DAPK1 [cytosol]
Stable Identifier
R-HSA-418262
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Death-associated protein kinase 1, DAPK1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
DAPK binds UNC5B (Homo sapiens)
DAPKs [cytosol] (Homo sapiens)
DAPK1 [cytosol] (Homo sapiens)
Unc5B with death domain:DAPK [cytosol] (Homo sapiens)
DAPKs [cytosol] (Homo sapiens)
DAPK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53355 DAPK1
Gene Names
DAPK1, DAPK
Chain
chain:1-1430
Reference Genes
BioGPS Gene:1612 DAPK1
COSMIC (genes):DAPK1 DAPK1
CTD Gene:1612 DAPK1
dbSNP Gene:1612 DAPK1
ENSEMBL:ENSG00000196730 DAPK1
HGNC:2674 DAPK1
KEGG:hsa:1612 DAPK1
Monarch:1612 DAPK1
NCBI Gene:1612 DAPK1
OMIM:600831 DAPK1
UCSC:P53355 DAPK1
Reference Transcript
RefSeq:NM_001288731.1 DAPK1
RefSeq:NM_001288729.1 DAPK1
RefSeq:NM_001288730.1 DAPK1
RefSeq:NM_004938.3 DAPK1
Other Identifiers
11720146_a_at
11720147_a_at
11746545_a_at
11760470_at
1612
17086496
203139_PM_at
203139_at
211214_PM_s_at
211214_s_at
3170438
3170439
3177901
3177902
3177903
3177904
3177905
3177906
3177907
3177918
3177924
3177925
3177926
3177927
3177928
3177929
3177930
3177932
3177933
3177934
3177936
3177937
3177938
3177940
3177941
3177942
3177943
3177944
3177945
3177947
3177948
3177949
3177950
3177951
3177952
3177953
3177954
3177955
3177956
3177957
3177958
3177959
3177960
3177961
3177962
3177963
3178004
3178006
3178013
3178078
3178098
3178112
40049_at
8156199
A_14_P118103
A_14_P136128
A_23_P252163
A_24_P393449
A_33_P3737504
GE484162
GE60012
GO:0002357
GO:0002376
GO:0002834
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0005515
GO:0005516
GO:0005524
GO:0005525
GO:0005634
GO:0005737
GO:0005856
GO:0005886
GO:0006417
GO:0006468
GO:0006915
GO:0007165
GO:0008625
GO:0010506
GO:0010508
GO:0012501
GO:0014069
GO:0015629
GO:0016740
GO:0017075
GO:0017148
GO:0035556
GO:0042802
GO:0042981
GO:0043065
GO:0043066
GO:0043226
GO:0043280
GO:0045087
GO:0046777
GO:0071345
GO:0071346
GO:0071447
GO:0097190
GO:0098542
GO:0098978
GO:0106310
GO:0140096
GO:1904094
GO:1990722
GO:2000310
HMNXSV003005055
HMNXSV003052740
ILMN_1708340
PH_hs_0023201
TC09000398.hg
X76104_at
g13177655_3p_a_at
g4826683_3p_at
Participates
as a member of
DAPKs [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_001275659.1
,
NP_001275658.1
,
NP_004929.2
,
NP_001275660.1
ZINC - World Drugs
DAPK1_HUMAN
Guide to Pharmacology - Targets
2002
OpenTargets
ENSG00000196730
ENSEMBL
ENSP00000350785
,
ENST00000472284
,
ENST00000491893
,
ENST00000622514
,
ENSP00000386135
,
ENST00000408954
,
ENSP00000417076
,
ENSP00000484267
,
ENST00000469640
,
ENST00000358077
,
ENSP00000419026
,
ENSP00000418885
ZINC - FDA approved
DAPK1_HUMAN
ZINC - Substances
DAPK1_HUMAN
ZINC - Biogenic
DAPK1_HUMAN
ZINC target
P53355
PRO
P53355
PDB
1P4F
,
4TXC
,
2XUU
,
6AAR
,
4TL0
,
2W4K
,
1JKS
,
3DGK
,
6IN4
,
1IG1
,
5AUV
,
7CCV
,
2X0G
,
3GU8
,
4YPD
,
1YR5
,
3ZXT
,
5AV4
,
4PF4
,
4B4L
,
5AUX
,
5AV1
,
1JKL
,
2XZS
,
6QN4
,
3F5G
,
3GU6
,
2YAK
,
8IE6
,
3DFC
,
2Y4V
,
3GU4
,
5AV3
,
3EH9
,
8IE7
,
6QMO
,
1WVW
,
1JKT
,
1WVX
,
1WVY
,
6GY5
,
4YO4
,
3GUB
,
2W4J
,
2Y0A
,
5AUU
,
8PB1
,
7CCU
,
6FHB
,
2Y4P
,
5AUT
,
3GU7
,
5AUW
,
5AV0
,
1JKK
,
3EHA
,
8ODZ
,
8IE8
,
8OE4
,
4UV0
,
5AUY
,
5AUZ
,
3GU5
,
5AV2
,
6FHA
,
7CCW
,
8OE0
,
8IE5
,
3F5U
ZINC - Investigational
DAPK1_HUMAN
HPA
ENSG00000196730-DAPK1
Pharos - Targets
P53355
ZINC - Predictions - Purchasable
DAPK1_HUMAN
HMDB Protein
HMDBP01259
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13284 IFI30
1
IFI30 [lysosomal lumen]
(R-HSA-1031704)
0.725
6
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.618
5
UniProt:P63151 PPP2R2A
2
PPP2R2A [nucleoplasm]
(R-HSA-1564978)
PPP2R2A [cytosol]
(R-HSA-377253)
0.593
3
UniProt:Q14457 BECN1
4
BECN1 [cytosol]
(R-HSA-1632841)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
0.591
4
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.59
2
UniProt:P14618-1 PKM
2
PKM-1 [cytosol]
(R-HSA-71667)
PolyUb-PKM-1 [cytosol]
(R-HSA-9861692)
0.527
2
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.527
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text