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PIK3R4 [cytosol]
Stable Identifier
R-HSA-188010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PI3K class III regulatory subunit, p150, PI3-kinase p150 subunit, Vps15
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Homo sapiens)
AMBRA1:DYNLL1,DYNLL2:BECN1 complex [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Autophagosome maturation (Homo sapiens)
UVRAG complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
BECN1 complex:p-AMBRA1:DYNLL1,DYNLL2 [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Beclin-1 complex phosphorylates PtdIns (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Beclin-1 complex translocates to the ER (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
The phagophore extends from the PIP3-enriched structure (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [phagophore assembly site membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
AMBRA1:DYNLL1,DYNLL2:BECN1 complex [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
BECN1 complex:p-AMBRA1:DYNLL1,DYNLL2 [cytosol] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
ULK1 phosphorylates Beclin-1 (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
UVRAG complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
UVRAG complex [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Capturing cargo and formation of prebudding complex (Homo sapiens)
8:class I MHC:BECN1 complex [endoplasmic reticulum membrane] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
SARS-CoV-2 8:class I MHC binds BECN1 (Homo sapiens)
8:class I MHC:BECN1 complex [endoplasmic reticulum membrane] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Capturing cargo and formation of prebudding complex (Homo sapiens)
8:class I MHC:BECN1 complex [endoplasmic reticulum membrane] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)
PI3K class III [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
PI3K class III [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the Golgi membrane (Homo sapiens)
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Homo sapiens)
PIK3C2A/3 [cytosol] (Homo sapiens)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Synthesis of PIPs at the early endosome membrane (Homo sapiens)
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Homo sapiens)
PIK3C2A/3 [cytosol] (Homo sapiens)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Synthesis of PIPs at the late endosome membrane (Homo sapiens)
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Homo sapiens)
PIK3C2A/3 [cytosol] (Homo sapiens)
PIK3C3:Mn2+:PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3R4:Mn2+ [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
PI3K class III [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
activated TLR9:PI3K class III [cytosol] (Homo sapiens)
PI3K class III [cytosol] (Homo sapiens)
PIK3R4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99570 PIK3R4
Gene Names
PIK3R4, VPS15
Chain
initiator methionine:, chain:2-1358
Reference Genes
BioGPS Gene:30849 PIK3R4
COSMIC (genes):PIK3R4 PIK3R4
CTD Gene:30849 PIK3R4
dbSNP Gene:30849 PIK3R4
ENSEMBL:ENSG00000196455 PIK3R4
HGNC:8982 PIK3R4
KEGG:hsa:30849 PIK3R4
Monarch:30849 PIK3R4
NCBI Gene:30849 PIK3R4
OMIM:602610 PIK3R4
UCSC:Q99570 PIK3R4
Reference Transcript
RefSeq:NM_014602.2 PIK3R4
Other Identifiers
11719349_at
16959112
212740_PM_at
212740_at
2695205
2695206
2695207
2695208
2695209
2695210
2695212
2695213
2695214
2695215
2695219
2695220
2695222
2695223
2695224
2695225
2695226
2695227
2695228
2695229
2695231
2695234
2695235
2695237
2695241
2695245
2695246
2695248
2695249
2695250
30849
37901_at
8090639
A_23_P132526
GE60262
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005829
GO:0005856
GO:0005930
GO:0006468
GO:0006622
GO:0006623
GO:0006629
GO:0006886
GO:0006914
GO:0010506
GO:0015630
GO:0016020
GO:0016192
GO:0016236
GO:0016241
GO:0016740
GO:0030242
GO:0030670
GO:0031410
GO:0032465
GO:0032801
GO:0034271
GO:0034272
GO:0035032
GO:0036092
GO:0042149
GO:0043226
GO:0043231
GO:0043491
GO:0045022
GO:0045324
GO:0071561
GO:0097352
GO:0106310
GO:0140096
HMNXSV003014403
Hs.83050.0.S1_3p_at
ILMN_1715832
PH_hs_0023657
TC03001778.hg
Y08991_at
Participates
as a component of
PI3K class III [cytosol] (Homo sapiens)
PIK3R4:Mn2+ [cytosol] (Homo sapiens)
UVRAG complex [cytosol] (Homo sapiens)
Beclin-1 complex [endoplasmic reticulum membrane] (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [phagophore assembly site membrane] (Homo sapiens)
ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane] (Homo sapiens)
BECN1 complex [cytosol] (Homo sapiens)
Other forms of this molecule
PIK3R4 [phagocytic vesicle membrane]
Inferred To
pik3r4 [cytosol]
(Xenopus tropicalis)
Vps15 [cytosol]
(Drosophila melanogaster)
vps-15 [cytosol]
(Caenorhabditis elegans)
PIK3R4 [cytosol]
(Bos taurus)
PIK3R4 [cytosol]
(Canis familiaris)
PIK3R4 [cytosol]
(Dictyostelium discoideum)
PIK3R4 [cytosol]
(Gallus gallus)
PIK3R4 [cytosol]
(Mus musculus)
PIK3R4 [cytosol]
(Plasmodium falciparum)
PIK3R4 [cytosol]
(Rattus norvegicus)
PIK3R4 [cytosol]
(Saccharomyces cerevisiae)
PIK3R4 [cytosol]
(Schizosaccharomyces pombe)
PIK3R4 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_055417.1
Guide to Pharmacology - Targets
2157
ENSEMBL
ENST00000356763
,
ENSP00000349205
OpenTargets
ENSG00000196455
HPA
ENSG00000196455-PIK3R4
ZINC - Substances
PI3R4_HUMAN
ZINC target
Q99570
PRO
Q99570
Pharos - Targets
Q99570
HMDB Protein
HMDBP08851
PDB
8SRQ
,
8SOR
,
7BL1
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14457 BECN1
4
BECN1 [cytosol]
(R-HSA-1632841)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
0.875
10
UniProt:Q9P2Y5 UVRAG
2
UVRAG [cytosol]
(R-HSA-5668884)
UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9730510)
0.744
6
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.589
2
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