Reactome | 8 [extracellular region]

8 [extracellular region]

Stable Identifier

R-COV-9755410

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

extracellular region

Synonyms

ns8, ORF8 protein

GO Cellular Component

host extracellular space (0043655)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P0DTC8 8

Gene Names

Chain

signal peptide:1-15, chain:16-121

Reference Genes

BioGPS Gene:43740577 8

KEGG Gene (Hepatitis C Virus):43740577 8

Monarch:43740577 8

NCBI Gene:43740577 8

Reference Transcript

RefSeq:NC_045512.2 8

Participates

as a component of

8 homodimer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)

Other forms of this molecule

8 [endoplasmic reticulum lumen]

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

RefSeq

YP_009724396.1

PDB

7JX6, 7JTL

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15818 NPTX1			0.706	4
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.658	3
UniProt:Q9NYU1 UGGT2	1	UGGT2 [endoplasmic reticulum lumen] (R-HSA-548863)	0.643	3
UniProt:Q92820 GGH	4	GGH [specific granule lumen] (R-HSA-6799639) GGH [azurophil granule lumen] (R-HSA-6800950) GGH [extracellular region] (R-HSA-6799679) GGH [tertiary granule lumen] (R-HSA-6800911)	0.643	3
UniProt:Q96F46 IL17RA	1	IL17RA [plasma membrane] (R-HSA-447176)	0.623	3
UniProt:P01892 HLA-A	9	K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943073) HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943104) HLA class I histocompatibility antigen, A-2 alpha chain [ER to Golgi transport vesicle membrane] (R-HSA-983389) HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane] (R-HSA-182252) HLA class I histocompatibility antigen, A-2 alpha chain [phagocytic vesicle membrane] (R-HSA-1236884) HLA class I histocompatibility antigen, A-2 alpha chain [recycling endosome membrane] (R-HSA-8863857) HLA class I histocompatibility antigen, A-2 alpha chain [plasma membrane] (R-HSA-198892) HLA class I histocompatibility antigen, A-2 alpha chain [early endosome membrane] (R-HSA-182267) HLA class I histocompatibility antigen, A-2 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983075)	0.599	5
UniProt:Q99519 NEU1	8	NEU1 W23* [lysosomal lumen] (R-HSA-5674155) NEU1 W29* [lysosomal lumen] (R-HSA-5674174) NEU1 E377* [lysosomal lumen] (R-HSA-5674181) NEU1 R225P [lysosomal lumen] (R-HSA-5674167) NEU1 L303P [lysosomal lumen] (R-HSA-5674182) NEU1 [extracellular region] (R-HSA-6806158) NEU1 [specific granule lumen] (R-HSA-6806148) NEU1 [lysosomal lumen] (R-HSA-1605788)	0.527	2
UniProt:P58166 INHBE	1	INHBE [extracellular region] (R-HSA-1449700)	0.527	2
UniProt:Q8N0Z8 PUSL1			0.527	2
UniProt:O76061 STC2	2	p-STC2 [endoplasmic reticulum lumen] (R-HSA-8957078) STC2 [endoplasmic reticulum lumen] (R-HSA-8956705)	0.527	2
UniProt:P0C7P0 CISD3			0.527	2
UniProt:P29122 PCSK6	4	PCSK6 [plasma membrane] (R-HSA-8849792) PCSK6 [extracellular region] (R-HSA-6784630) PCSK6 [extracellular region] (R-HSA-1181107) PCSK6 [Golgi lumen] (R-HSA-3009047)	0.527	2
UniProt:Q08431 MFGE8	3	MFGE8(268-317) [extracellular region] (R-HSA-976952) p-MFGE8 [endoplasmic reticulum lumen] (R-HSA-8957017) MFGE8 [endoplasmic reticulum lumen] (R-HSA-8956715)	0.527	2
UniProt:P28300 LOX	3	LOX(22-168) [extracellular region] (R-HSA-2022074) LOX(22-417) [extracellular region] (R-HSA-2022071) LOX [extracellular region] (R-HSA-2022085)	0.527	2
UniProt:O14656 TOR1A	1	TOR1A [cytosol] (R-HSA-8862858)	0.527	2
UniProt:Q9Y680 FKBP7			0.527	2
UniProt:Q8IWF2 FXRD2			0.527	2
UniProt:Q9P2E5 CHPF2	1	CHPF2 [Golgi membrane] (R-HSA-1971502)	0.527	2
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.527	2
UniProt:Q9BS26 ERP44	2	ERP44 [extracellular region] (R-HSA-6806302) ERP44 [specific granule lumen] (R-HSA-6799567)	0.527	2
UniProt:Q9UHI8 ADAMTS1	4	ADAMTS1 [extracellular region] (R-HSA-3791292) ADAMTS1 [endoplasmic reticulum lumen] (R-HSA-5173121) glc-fuc-ADAMTS1 [endoplasmic reticulum lumen] (R-HSA-5173006) O-fuc-ADAMTS1 [endoplasmic reticulum lumen] (R-HSA-5172971)	0.527	2
UniProt:Q86YB8 ERO1B	1	ERO1B [endoplasmic reticulum lumen] (R-HSA-4084704)	0.527	2
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.527	2
UniProt:P61916 NPC2	3	NPC2 [lysosomal lumen] (R-HSA-8876488) NPC2 [extracellular region] (R-HSA-6806224) NPC2 [azurophil granule lumen] (R-HSA-6799163)	0.527	2
UniProt:Q9H488 POFUT1	1	POFUT1 [endoplasmic reticulum membrane] (R-HSA-1460374)	0.527	2
UniProt:Q9H4F8 SMOC1			0.527	2
UniProt:Q8N766 EMC1			0.527	2
UniProt:Q9NXK8 FBXL12	1	FBXL12 [cytosol] (R-HSA-8862611)	0.527	2
UniProt:Q13443 ADAM9	1	ADAM9 [plasma membrane] (R-HSA-708336)	0.527	2
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [extracellular region] (R-HSA-3221939)	0.527	2
UniProt:Q96IV0 NGLY1	1	NGLY1 [cytosol] (R-HSA-8850591)	0.527	2
UniProt:Q99470 SDF2			0.527	2
UniProt:Q9H8W4 PKHF2			0.527	2
UniProt:O00469 PLOD2	1	PLOD2 [endoplasmic reticulum membrane] (R-HSA-1981126)	0.527	2
UniProt:Q99988 GDF15			0.527	2
UniProt:Q96MM7 HS6ST2	1	HS6ST2 [Golgi membrane] (R-HSA-2076353)	0.527	2
UniProt:Q8IZ52 CHPF	1	CHPF [Golgi membrane] (R-HSA-1971533)	0.527	2
UniProt:Q96AY3 FKB10			0.527	2
UniProt:Q6UW63 PLGT2			0.527	2
UniProt:Q9BRN9 TM2D3			0.527	2
UniProt:P00750 PLAT	3	PLAT(311-562) [extracellular region] (R-HSA-158762) PLAT(36-310) [extracellular region] (R-HSA-158758) PLAT(36-562) [extracellular region] (R-HSA-158754)	0.527	2
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.527	2
UniProt:Q7Z4H8 PLGT3			0.527	2
UniProt:Q8NE01 CNNM3			0.527	2
UniProt:P12109 COL6A1	20	GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023521) 3x4Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023651) GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023608) 3x4Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023576) 3x4Hyp-3Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023560) 3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023660) COL6A1 [endoplasmic reticulum lumen] (R-HSA-1614453) 3x4Hyp-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022508) 3x4Hyp-3Hyp-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022507) 3x4Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022965) 3x4Hyp-3Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022944) 5Hyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022997) 3x4Hyp-COL6A1(?-1028) [extracellular region] (R-HSA-2470138) COL6A1(?-1028) [extracellular region] (R-HSA-2470040) 3x4Hyp-COL6A1(20-?) [extracellular region] (R-HSA-2470073) GalHyl-COL6A1(20-?) [extracellular region] (R-HSA-2470046) 3x4Hyp-5Hyl-COL6A1(?-1028) [extracellular region] (R-HSA-2470143) 3x4Hyp-3Hyp-5Hyl-COL6A1(20-?) [extracellular region] (R-HSA-2470066) GlcGalHyl-COL6A1(20-?) [extracellular region] (R-HSA-2470033) 3x4Hyp-3Hyp-GalHyl-COL6A1(?-1028) [extracellular region] (R-HSA-2470103)	0.527	2
UniProt:Q9H173 SIL1			0.527	2
UniProt:Q96DZ1 ERLEC1	1	ERLEC1 [endoplasmic reticulum quality control compartment] (R-HSA-5362354)	0.527	2
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.527	2
UniProt:Q9BZQ6 EDEM3	1	EDEM3 [endoplasmic reticulum quality control compartment] (R-HSA-1022110)	0.527	2
UniProt:Q8IV08 PLD3	2	PLD3 [endoplasmic reticulum membrane] (R-HSA-1498798) PLD3 [plasma membrane] (R-HSA-2029042)	0.527	2
UniProt:Q14457 BECN1	3	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.463	2

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