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8 [extracellular region]
Stable Identifier
R-COV-9755410
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
extracellular region
Synonyms
ns8, ORF8 protein
GO Cellular Component
host extracellular space
(0043655)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F (Homo sapiens)
8:IL17RA [plasma membrane] (Homo sapiens)
8 homodimer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
8 [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
8 homodimer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
8 [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 8 binds IL17RA (Homo sapiens)
8:IL17RA [plasma membrane] (Homo sapiens)
8 homodimer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
8 [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
8 homodimer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
8 [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F (Homo sapiens)
8:IL17RA [plasma membrane] (Homo sapiens)
8 homodimer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
8 [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
8 homodimer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
8 [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
External Reference Information
External Reference
UniProt:P0DTC8 8
Gene Names
8
Chain
signal peptide:1-15, chain:16-121
Reference Genes
BioGPS Gene:43740577 8
KEGG Gene (Hepatitis C Virus):43740577 8
Monarch:43740577 8
NCBI Gene:43740577 8
Reference Transcript
RefSeq:NC_045512.2 8
Participates
as a component of
8 homodimer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
Other forms of this molecule
8 [endoplasmic reticulum lumen]
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
RefSeq
YP_009724396.1
PDB
7JX6
,
7JTL
Interactors (51)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15818 NPTX1
0.706
4
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.658
3
UniProt:Q9NYU1 UGGT2
1
UGGT2 [endoplasmic reticulum lumen]
(R-HSA-548863)
0.643
3
UniProt:Q92820 GGH
4
GGH [specific granule lumen]
(R-HSA-6799639)
GGH [azurophil granule lumen]
(R-HSA-6800950)
GGH [extracellular region]
(R-HSA-6799679)
GGH [tertiary granule lumen]
(R-HSA-6800911)
0.643
3
UniProt:Q96F46 IL17RA
1
IL17RA [plasma membrane]
(R-HSA-447176)
0.623
3
UniProt:P01892 HLA-A
9
K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane]
(R-HSA-8943073)
HLA-A A-2 [endoplasmic reticulum membrane]
(R-HSA-8943104)
HLA class I histocompatibility antigen, A-2 alpha chain [ER to Golgi transport vesicle membrane]
(R-HSA-983389)
HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane]
(R-HSA-182252)
HLA class I histocompatibility antigen, A-2 alpha chain [phagocytic vesicle membrane]
(R-HSA-1236884)
HLA class I histocompatibility antigen, A-2 alpha chain [recycling endosome membrane]
(R-HSA-8863857)
HLA class I histocompatibility antigen, A-2 alpha chain [plasma membrane]
(R-HSA-198892)
HLA class I histocompatibility antigen, A-2 alpha chain [early endosome membrane]
(R-HSA-182267)
HLA class I histocompatibility antigen, A-2 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983075)
0.599
5
UniProt:Q99519 NEU1
8
NEU1 W23* [lysosomal lumen]
(R-HSA-5674155)
NEU1 W29* [lysosomal lumen]
(R-HSA-5674174)
NEU1 E377* [lysosomal lumen]
(R-HSA-5674181)
NEU1 R225P [lysosomal lumen]
(R-HSA-5674167)
NEU1 L303P [lysosomal lumen]
(R-HSA-5674182)
NEU1 [extracellular region]
(R-HSA-6806158)
NEU1 [specific granule lumen]
(R-HSA-6806148)
NEU1 [lysosomal lumen]
(R-HSA-1605788)
0.527
2
UniProt:P58166 INHBE
1
INHBE [extracellular region]
(R-HSA-1449700)
0.527
2
UniProt:Q8N0Z8 PUSL1
0.527
2
UniProt:O76061 STC2
2
p-STC2 [endoplasmic reticulum lumen]
(R-HSA-8957078)
STC2 [endoplasmic reticulum lumen]
(R-HSA-8956705)
0.527
2
UniProt:P0C7P0 CISD3
0.527
2
UniProt:P29122 PCSK6
4
PCSK6 [plasma membrane]
(R-HSA-8849792)
PCSK6 [extracellular region]
(R-HSA-6784630)
PCSK6 [extracellular region]
(R-HSA-1181107)
PCSK6 [Golgi lumen]
(R-HSA-3009047)
0.527
2
UniProt:Q08431 MFGE8
3
MFGE8(268-317) [extracellular region]
(R-HSA-976952)
p-MFGE8 [endoplasmic reticulum lumen]
(R-HSA-8957017)
MFGE8 [endoplasmic reticulum lumen]
(R-HSA-8956715)
0.527
2
UniProt:P28300 LOX
3
LOX(22-168) [extracellular region]
(R-HSA-2022074)
LOX(22-417) [extracellular region]
(R-HSA-2022071)
LOX [extracellular region]
(R-HSA-2022085)
0.527
2
UniProt:O14656 TOR1A
1
TOR1A [cytosol]
(R-HSA-8862858)
0.527
2
UniProt:Q9Y680 FKBP7
0.527
2
UniProt:Q8IWF2 FXRD2
0.527
2
UniProt:Q9P2E5 CHPF2
1
CHPF2 [Golgi membrane]
(R-HSA-1971502)
0.527
2
UniProt:P26358 DNMT1
2
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
DNMT1 [nucleoplasm]
(R-HSA-212181)
0.527
2
UniProt:Q9BS26 ERP44
2
ERP44 [extracellular region]
(R-HSA-6806302)
ERP44 [specific granule lumen]
(R-HSA-6799567)
0.527
2
UniProt:Q9UHI8 ADAMTS1
4
ADAMTS1 [extracellular region]
(R-HSA-3791292)
ADAMTS1 [endoplasmic reticulum lumen]
(R-HSA-5173121)
glc-fuc-ADAMTS1 [endoplasmic reticulum lumen]
(R-HSA-5173006)
O-fuc-ADAMTS1 [endoplasmic reticulum lumen]
(R-HSA-5172971)
0.527
2
UniProt:Q86YB8 ERO1B
1
ERO1B [endoplasmic reticulum lumen]
(R-HSA-4084704)
0.527
2
UniProt:P05556 ITGB1
2
ITGB1 [endosome membrane]
(R-HSA-9611157)
ITGB1 [plasma membrane]
(R-HSA-57596)
0.527
2
UniProt:P61916 NPC2
3
NPC2 [lysosomal lumen]
(R-HSA-8876488)
NPC2 [extracellular region]
(R-HSA-6806224)
NPC2 [azurophil granule lumen]
(R-HSA-6799163)
0.527
2
UniProt:Q9H488 POFUT1
1
POFUT1 [endoplasmic reticulum membrane]
(R-HSA-1460374)
0.527
2
UniProt:Q9H4F8 SMOC1
0.527
2
UniProt:Q8N766 EMC1
0.527
2
UniProt:Q9NXK8 FBXL12
1
FBXL12 [cytosol]
(R-HSA-8862611)
0.527
2
UniProt:Q13443 ADAM9
1
ADAM9 [plasma membrane]
(R-HSA-708336)
0.527
2
UniProt:Q9Y4L1 HYOU1
3
HYOU1 [endoplasmic reticulum lumen]
(R-HSA-535542)
HYOU1 [endocytic vesicle lumen]
(R-HSA-3221924)
HYOU1 [extracellular region]
(R-HSA-3221939)
0.527
2
UniProt:Q96IV0 NGLY1
1
NGLY1 [cytosol]
(R-HSA-8850591)
0.527
2
UniProt:Q99470 SDF2
0.527
2
UniProt:Q9H8W4 PKHF2
0.527
2
UniProt:O00469 PLOD2
1
PLOD2 [endoplasmic reticulum membrane]
(R-HSA-1981126)
0.527
2
UniProt:Q99988 GDF15
0.527
2
UniProt:Q96MM7 HS6ST2
1
HS6ST2 [Golgi membrane]
(R-HSA-2076353)
0.527
2
UniProt:Q8IZ52 CHPF
1
CHPF [Golgi membrane]
(R-HSA-1971533)
0.527
2
UniProt:Q96AY3 FKB10
0.527
2
UniProt:Q6UW63 PLGT2
0.527
2
UniProt:Q9BRN9 TM2D3
0.527
2
UniProt:P00750 PLAT
3
PLAT(311-562) [extracellular region]
(R-HSA-158762)
PLAT(36-310) [extracellular region]
(R-HSA-158758)
PLAT(36-562) [extracellular region]
(R-HSA-158754)
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
2
UniProt:Q7Z4H8 PLGT3
0.527
2
UniProt:Q8NE01 CNNM3
0.527
2
UniProt:P12109 COL6A1
20
GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023521)
3x4Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023651)
GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023608)
3x4Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023576)
3x4Hyp-3Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023560)
3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2023660)
COL6A1 [endoplasmic reticulum lumen]
(R-HSA-1614453)
3x4Hyp-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022508)
3x4Hyp-3Hyp-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022507)
3x4Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022965)
3x4Hyp-3Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022944)
5Hyl-COL6A1 [endoplasmic reticulum lumen]
(R-HSA-2022997)
3x4Hyp-COL6A1(?-1028) [extracellular region]
(R-HSA-2470138)
COL6A1(?-1028) [extracellular region]
(R-HSA-2470040)
3x4Hyp-COL6A1(20-?) [extracellular region]
(R-HSA-2470073)
GalHyl-COL6A1(20-?) [extracellular region]
(R-HSA-2470046)
3x4Hyp-5Hyl-COL6A1(?-1028) [extracellular region]
(R-HSA-2470143)
3x4Hyp-3Hyp-5Hyl-COL6A1(20-?) [extracellular region]
(R-HSA-2470066)
GlcGalHyl-COL6A1(20-?) [extracellular region]
(R-HSA-2470033)
3x4Hyp-3Hyp-GalHyl-COL6A1(?-1028) [extracellular region]
(R-HSA-2470103)
0.527
2
UniProt:Q9H173 SIL1
0.527
2
UniProt:Q96DZ1 ERLEC1
1
ERLEC1 [endoplasmic reticulum quality control compartment]
(R-HSA-5362354)
0.527
2
UniProt:P15151 PVR
1
PVR [plasma membrane]
(R-HSA-420600)
0.527
2
UniProt:Q9BZQ6 EDEM3
1
EDEM3 [endoplasmic reticulum quality control compartment]
(R-HSA-1022110)
0.527
2
UniProt:Q8IV08 PLD3
2
PLD3 [endoplasmic reticulum membrane]
(R-HSA-1498798)
PLD3 [plasma membrane]
(R-HSA-2029042)
0.527
2
UniProt:Q14457 BECN1
3
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.463
2
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