Reactome | FGB(31-491) [platelet alpha granule lumen]

FGB(31-491) [platelet alpha granule lumen]

Stable Identifier

R-HSA-140921

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

fibrinogen B beta chain

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02675 FGB

Gene Names

FGB

Chain

signal peptide:1-30, peptide:31-44, chain:45-491

Reference Genes

BioGPS Gene:2244 FGB

COSMIC (genes):FGB FGB

CTD Gene:2244 FGB

dbSNP Gene:2244 FGB

ENSEMBL:ENSG00000171564 FGB

ENSEMBL_homo_sapiens_GENE:ENSG00000171564.12 FGB

HGNC:3662 FGB

KEGG Gene (Homo sapiens):2244 FGB

Monarch:2244 FGB

NCBI Gene:2244 FGB

OMIM:134830 FGB

Reference Transcript

Other Identifiers

11715628_a_at

11746819_a_at

11755934_x_at

11758728_at

16971643

204988_PM_at

204988_at

216238_PM_s_at

216238_s_at

2244

2748550

2748554

2748555

2748556

2748557

2748560

2748562

2748564

2748565

2748566

2748567

2748568

2748569

2748570

37019_at

47589_at

63760_at

78341_at

8097910

A_14_P100691

A_23_P136125

GE62817

GO:0002250

GO:0002376

GO:0003013

GO:0005102

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005577

GO:0005615

GO:0005783

GO:0005886

GO:0005938

GO:0007155

GO:0007160

GO:0007596

GO:0007599

GO:0009897

GO:0009986

GO:0012501

GO:0016192

GO:0023052

GO:0030168

GO:0030312

GO:0031012

GO:0031091

GO:0031093

GO:0031410

GO:0031639

GO:0034116

GO:0042060

GO:0042730

GO:0043152

GO:0043226

GO:0044320

GO:0045087

GO:0045202

GO:0045907

GO:0045921

GO:0050714

GO:0050839

GO:0051087

GO:0051258

GO:0051592

GO:0051604

GO:0062023

GO:0065003

GO:0070062

GO:0070374

GO:0070527

GO:0071347

GO:0072378

GO:0072562

GO:0090277

GO:0098542

GO:1900026

GO:1902042

GO:1903561

GO:2000352

HMNXSV003033495

Hs.7645.1.S1_3p_a_at

Hs.7645.1.S1_3p_x_at

ILMN_1678049

ILMN_2114972

J00129_at

PH_hs_0023603

TC04000777.hg

g11761630_3p_at

Participates

as a component of

fibrinogen [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

FGB(31-491) [extracellular region]

FGB [plasma membrane]

FGB(31-44) [extracellular region]

FGB [extracellular region]

Inferred To

FGB(31-491) [platelet alpha granule lumen] (Gallus gallus)

Fgb [platelet alpha granule lumen] (Mus musculus)

Fgb [platelet alpha granule lumen] (Rattus norvegicus)

FGB [platelet alpha granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_001171670.1, NP_005132.2

OpenTargets

ENSG00000171564

HPA

ENSG00000171564-FGB

GeneCards

P02675

Ensembl

ENSG00000171564, ENST00000302068, ENSP00000306099

PRO

P02675

Pharos - Targets

P02675

Orphanet

16041

HMDB Protein

HMDBP13514

PDB

1RF1, 3GHG, 6V19, 1FZC, 6V18, 1FZE, 2Q9I, 1FZF, 1N8E, 1FZG, 1RE3, 1LT9, 2HOD, 6V1A, 6BIJ, 1RE4, 6BIL, 2OYH, 2OYI, 2A45, 3HUS, 2FFD, 2XNX, 3H32, 1LTJ, 3BVH, 2XNY, 6V0Y, 2HPC, 2H43, 6V13, 6ATZ, 1N86, 1RF0, 1FZA, 2Z4E, 3E1I, 1FZB, 2HLO, 6V15

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02671 FGA	8	FGA(20-866) [platelet alpha granule lumen] (R-HSA-140920) FGA(20-866) [extracellular region] (R-HSA-140841) Variant fibrinogen alpha chain [extracellular region] (R-HSA-976905) p-FGA [endoplasmic reticulum lumen] (R-HSA-8957043) FGA [endoplasmic reticulum lumen] (R-HSA-8956714) FGA [plasma membrane] (R-HSA-140916) FGA(20-35) [extracellular region] (R-HSA-140867) FGA [extracellular region] (R-HSA-140583)	0.852	11
UniProt:P27958-PRO_0000037566			0.543	4
UniProt:Q9GZZ1 NAA50			0.527	2
UniProt:Q9Y490 TLN1	4	TLN1 [extracellular region] (R-HSA-350693) TLN1(434-2541) [cytosol] (R-HSA-9855156) TLN1(1-433) [cytosol] (R-HSA-9855031) TLN1 [cytosol] (R-HSA-350713)	0.527	2
UniProt:Q9H993 ARMT1			0.527	2
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.527	2
UniProt:Q9NQG5 RPRD1B	1	RPRD1B [nucleoplasm] (R-HSA-6814894)	0.527	2
UniProt:Q9UNH7 SNX6			0.527	2
UniProt:Q00341 HDLBP	1	HDLBP [plasma membrane] (R-HSA-8858026)	0.527	2
UniProt:O95747 OXSR1			0.527	2
UniProt:Q08752 PPID	1	PPID [nucleoplasm] (R-HSA-8939168)	0.527	2
UniProt:Q9C0B1 FTO	1	FTO [nucleoplasm] (R-HSA-8857715)	0.527	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.527	2
UniProt:Q96KB5 TOPK			0.527	2
UniProt:O43252 PAPSS1	3	PAPSS1 [cytosol] (R-HSA-174387) PAPSS1(1-223)-BRAF(381-766) fusion [cytosol] (R-HSA-6802432) PAPSS1(1-223)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802543)	0.527	2
UniProt:P30043 BLVRB	1	BLVRB [cytosol] (R-HSA-189388)	0.527	2
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.527	2
UniProt:P62495 ETF1	3	Me-Q185-ETF1 [cytosol] (R-HSA-6800157) 4OHK63-ETF1 [cytosol] (R-HSA-9629948) ETF1 [cytosol] (R-HSA-54433)	0.527	2
UniProt:Q9NTZ6 RBM12			0.527	2
UniProt:Q15126 PMVK	1	PMVK [cytosol] (R-HSA-191348)	0.527	2
UniProt:O43583 DENR			0.527	2
UniProt:Q9NVS9 PNPO	1	PNPO [cytosol] (R-HSA-965023)	0.527	2
UniProt:Q9BXJ9 NAA15			0.527	2
UniProt:Q9Y3A5 SBDS			0.527	2
UniProt:Q58FG1 HS904			0.527	2
UniProt:O75436 VPS26A	1	VPS26A [cytosol] (R-HSA-3247739)	0.527	2
UniProt:O95202 LETM1	2	LETM1 [endoplasmic reticulum membrane] (R-HSA-9714759) LETM1 [mitochondrial inner membrane] (R-HSA-8949702)	0.527	2
UniProt:P36915 GNL1			0.527	2
UniProt:P05091 ALDH2	1	ALDH2 [mitochondrial matrix] (R-HSA-71718)	0.527	2
UniProt:Q07960 ARHGAP1	1	ARHGAP1 [cytosol] (R-HSA-195193)	0.527	2
UniProt:Q9BY32 ITPA	1	ITPA [cytosol] (R-HSA-2509850)	0.527	2
UniProt:Q96A49 SYAP1			0.527	2
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.527	2
UniProt:P06899 H2BC11	9	Ub-HIST1H2BJ [nucleoplasm] (R-HSA-6782566) AcK-HIST1H2BJ [nucleoplasm] (R-HSA-4549258) HIST1H2BJ [extracellular region] (R-HSA-977565) AcK21-HIST1H2BJ [nucleoplasm] (R-HSA-4568671) AcK6-HIST1H2BJ [nucleoplasm] (R-HSA-4568668) AcK16-HIST1H2BJ [nucleoplasm] (R-HSA-4568704) AcK13-HIST1H2BJ [nucleoplasm] (R-HSA-4568662) Ub-121-HIST1H2BJ [nucleoplasm] (R-HSA-3364017) HIST1H2BJ [nucleoplasm] (R-HSA-181900)	0.527	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	2
UniProt:O60493 SNX3	3	SNX3 [cytosol] (R-HSA-3247743) PolyUb-SNX3 [endosome membrane] (R-HSA-6782993) SNX3 [endosome membrane] (R-HSA-6782991)	0.527	2
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.527	2
UniProt:Q99986 VRK1	2	VRK1 [nucleoplasm] (R-HSA-2528998) VRK1 [cytosol] (R-HSA-2995381)	0.527	2
UniProt:Q8WVY7 UBCP1			0.527	2
UniProt:Q9BY44 EIF2A			0.527	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:Q8WZA0 LZIC			0.527	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.527	2
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.527	2
UniProt:O60361 NME2P1	1	NME2P1 [cytosol] (R-HSA-6806876)	0.527	2
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.527	2
UniProt:O00625 PIR	1	PIR [nucleoplasm] (R-HSA-8953390)	0.527	2
UniProt:Q16659 MAPK6 gene	6	ub-MAPK6 [cytosol] (R-HSA-5687000) MAPK6 [cytosol] (R-HSA-5686979) p-S189 MAPK6 [cytosol] (R-HSA-5687019) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665)	0.527	2
UniProt:Q9NPD8 UBE2T	3	Ub-C86-UBE2T [nucleoplasm] (R-HSA-8864217) UBE2T [nucleoplasm] (R-HSA-420942) MonoUb-K91,K182-UBE2T [nucleoplasm] (R-HSA-6785362)	0.527	2
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.527	2
UniProt:P39748 FEN1	1	FEN1 [nucleoplasm] (R-HSA-54745)	0.527	2
UniProt:Q01581 HMGCS1	1	HMGCS1 [cytosol] (R-HSA-191329)	0.527	2
UniProt:O43776 NARS1	1	NARS [cytosol] (R-HSA-379625)	0.527	2

Cite Us!