Reactome | FGB(31-491) [platelet alpha granule lumen]

FGB(31-491) [platelet alpha granule lumen]

Stable Identifier

R-HSA-140921

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

fibrinogen B beta chain

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02675 FGB

Gene Names

FGB

Chain

signal peptide:1-30, peptide:31-44, chain:45-491

Reference Genes

BioGPS Gene:2244 FGB

COSMIC (genes):FGB FGB

CTD Gene:2244 FGB

dbSNP Gene:2244 FGB

ENSEMBL:ENSG00000171564 FGB

ENSEMBL:ENSG00000171564.12 FGB

HGNC:3662 FGB

KEGG Gene (Homo sapiens):2244 FGB

Monarch:2244 FGB

NCBI Gene:2244 FGB

OMIM:134830 FGB

Reference Transcript

Other Identifiers

11715628_a_at

11746819_a_at

11755934_x_at

11758728_at

16971643

204988_PM_at

204988_at

216238_PM_s_at

216238_s_at

2244

2748550

2748554

2748555

2748556

2748557

2748560

2748562

2748564

2748565

2748566

2748567

2748568

2748569

2748570

37019_at

47589_at

63760_at

78341_at

8097910

A_14_P100691

A_23_P136125

GE62817

GO:0002250

GO:0002376

GO:0003013

GO:0005102

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005577

GO:0005615

GO:0005783

GO:0005886

GO:0005938

GO:0007155

GO:0007160

GO:0007596

GO:0007599

GO:0009897

GO:0009986

GO:0012501

GO:0016192

GO:0023052

GO:0030154

GO:0030168

GO:0030312

GO:0031012

GO:0031091

GO:0031093

GO:0031410

GO:0031639

GO:0034116

GO:0042060

GO:0042730

GO:0043152

GO:0043226

GO:0044320

GO:0045087

GO:0045202

GO:0045907

GO:0045921

GO:0048856

GO:0050714

GO:0050839

GO:0051087

GO:0051258

GO:0051592

GO:0051604

GO:0062023

GO:0065003

GO:0070062

GO:0070374

GO:0070527

GO:0071347

GO:0072378

GO:0072562

GO:0090277

GO:0098542

GO:0110165

GO:1900026

GO:1902042

GO:1903561

GO:2000352

HMNXSV003033495

Hs.7645.1.S1_3p_a_at

Hs.7645.1.S1_3p_x_at

ILMN_1678049

ILMN_2114972

J00129_at

PH_hs_0023603

TC04000777.hg

g11761630_3p_at

Participates

as a component of

fibrinogen [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

FGB(31-491) [extracellular region]

FGB [plasma membrane]

FGB(31-44) [extracellular region]

FGB [extracellular region]

Inferred To

FGB(31-491) [platelet alpha granule lumen] (Gallus gallus)

wu:fa55c11 [platelet alpha granule lumen] (Danio rerio)

Fgb [platelet alpha granule lumen] (Mus musculus)

Fgb [platelet alpha granule lumen] (Rattus norvegicus)

FGB [platelet alpha granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_005132.2, NP_001171670.1

OpenTargets

ENSG00000171564

GeneCards

P02675

HPA

ENSG00000171564-FGB

Ensembl

ENSG00000171564, ENSP00000306099, ENST00000302068

PRO

P02675

Pharos - Targets

P02675

Orphanet

16041

HMDB Protein

HMDBP13514

PDB

2XNY, 1FZG, 2HLO, 6V13, 6ATZ, 1N8E, 3HUS, 2HPC, 6V0Y, 3H32, 1FZF, 2H43, 2XNX, 6V15, 1RF1, 3BVH, 1RF0, 1N86, 6V18, 1FZE, 6V19, 1FZC, 2OYI, 2OYH, 2FFD, 2A45, 1FZA, 6BIJ, 6BIL, 1FZB, 6V1A, 2HOD, 1LTJ, 2Q9I, 3GHG, 1RE3, 1RE4, 2Z4E, 1LT9, 3E1I

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02671 FGA	8	FGA(20-866) [platelet alpha granule lumen] (R-HSA-140920) FGA(20-866) [extracellular region] (R-HSA-140841) Variant fibrinogen alpha chain [extracellular region] (R-HSA-976905) p-FGA [endoplasmic reticulum lumen] (R-HSA-8957043) FGA [endoplasmic reticulum lumen] (R-HSA-8956714) FGA [plasma membrane] (R-HSA-140916) FGA(20-35) [extracellular region] (R-HSA-140867) FGA [extracellular region] (R-HSA-140583)	0.852	11
UniProt:P27958-PRO_0000037566			0.543	4