Reactome | ALDH2 [mitochondrial matrix]

ALDH2 [mitochondrial matrix]

Stable Identifier

R-HSA-71718

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

aldehyde dehydrogenase, mitochondrial, ALDH class 2, DHAM_HUMAN, Aldehyde dehydrogenase, mitochondrial precursor , ALDHI, ALDH-E2

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
4065146	Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. Kaiser, R, Jornvall, H, Hempel, J	Eur J Biochem	1985
18196	Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes. Greenfield, NJ, Pietruszko, R	Biochim Biophys Acta	1977

External Reference Information

External Reference

UniProt:P05091 ALDH2

Gene Names

ALDH2, ALDM

Chain

transit peptide:1-17, chain:18-517

Reference Genes

BioGPS Gene:217 ALDH2

COSMIC (genes):ALDH2 ALDH2

CTD Gene:217 ALDH2

dbSNP Gene:217 ALDH2

ENSEMBL:ENSG00000111275 ALDH2

HGNC:404 ALDH2

KEGG:hsa:217 ALDH2

Monarch:217 ALDH2

NCBI Gene:217 ALDH2

UCSC:P05091 ALDH2

Reference Transcript

Other Identifiers

11715627_x_at

11746896_a_at

16757160

16757178

201425_PM_at

201425_at

217

2439266

32747_at

3361139

3432092

3432094

3432096

3432097

3432099

3432101

3432102

3432103

3432105

3432108

3432110

3432111

3432112

3432113

3432114

3432117

3432118

3432119

3432121

3432123

3432125

3432127

3432128

3432130

3432132

3432134

3432135

7958784

84527_at

A_14_P108452

A_23_P36745

A_23_P36753

GE61664

GE899092

GO:0003824

GO:0004029

GO:0004030

GO:0005739

GO:0005759

GO:0005975

GO:0006066

GO:0006068

GO:0008957

GO:0009055

GO:0016491

GO:0016620

GO:0016787

GO:0018937

GO:0043226

GO:0043878

GO:0046185

GO:0051287

GO:0070062

GO:0106435

GO:1903179

GO:1905627

HMNXSV003000936

HMNXSV003019489

ILMN_1793859

PH_hs_0033390

TC12000871.hg

TC12003212.hg

X05409_at

g4502032_3p_at

p3852

Participates

as a member of

as a component of

ALDH2 tetramer [mitochondrial matrix] (Homo sapiens)

Inferred To

Aldh [mitochondrial matrix] (Drosophila melanogaster)

ALDH2 [mitochondrial matrix] (Bos taurus)

ALDH2 [mitochondrial matrix] (Canis familiaris)

ALDH2 [mitochondrial matrix] (Dictyostelium discoideum)

ALDH2 [mitochondrial matrix] (Gallus gallus)

ALDH2 [mitochondrial matrix] (Mus musculus)

ALDH2 [mitochondrial matrix] (Rattus norvegicus)

ALDH2 [mitochondrial matrix] (Saccharomyces cerevisiae)

ALDH2 [mitochondrial matrix] (Schizosaccharomyces pombe)

ALDH2 [mitochondrial matrix] (Sus scrofa)

aldh2.2 [mitochondrial matrix] (Danio rerio)

Homologues of ALDH2 [mitochondrial matrix] (Dictyostelium discoideum)

Homologues of ALDH2 [mitochondrial matrix] (Saccharomyces cerevisiae)

aldh2 [mitochondrial matrix] (Xenopus tropicalis)

hydA [mitochondrial matrix] (Dictyostelium discoideum)

alh-1 [mitochondrial matrix] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

2595

OpenTargets

ENSG00000111275

ENSEMBL

ENST00000416293, ENSP00000403349, ENSG00000111275, ENSP00000261733, ENST00000261733

ZINC - Substances

ALDH2_HUMAN

ZINC - Biogenic

ALDH2_HUMAN

ZINC target

P05091

PRO

P05091

GlyGen

P05091

PDB

5L13, 2VLE, 2ONP, 2ONM, 2ONO, 2ONN, 3SZ9, 1ZUM, 8SHS, 1O02, 3N82, 1NZZ, 1O00, 1O01, 1O05, 1O04, 1NZX, 3N83, 1NZW, 4KWG, 4FR8, 3N80, 4FQF, 3INJ, 4KWF, 8DR9, 3INL, 3N81, 1CW3

ZINC - Metabolites

ALDH2_HUMAN

HPA

ENSG00000111275-ALDH2

GeneCards

ALDH2

Pharos - Targets

P05091

ZINC - Predictions - Purchasable

ALDH2_HUMAN

HMDB Protein

HMDBP00295

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02787 TF	6	TF [endoplasmic reticulum lumen] (R-HSA-8956763) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) apoTF [extracellular region] (R-HSA-350754) apoTF [endosome membrane] (R-HSA-917974) TF [secretory granule lumen] (R-HSA-350704) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q02252 ALDH6A1	1	ALDH6A1 [mitochondrial matrix] (R-HSA-70890)	0.527	2
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.527	2
UniProt:P02647 APOA1	11	APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-266) [secretory granule lumen] (R-HSA-350761)	0.527	2

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