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ALDH2 [mitochondrial matrix]
Stable Identifier
R-HSA-71718
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
aldehyde dehydrogenase, mitochondrial, ALDH class 2, DHAM_HUMAN, Aldehyde dehydrogenase, mitochondrial precursor , ALDHI, ALDH-E2
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Ethanol oxidation (Homo sapiens)
acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Homo sapiens)
ALDH2 tetramer [mitochondrial matrix] (Homo sapiens)
ALDH2 [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
CLPXP binds mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ALDH2 [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ALDH2 [mitochondrial matrix] (Homo sapiens)
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ALDH2 [mitochondrial matrix] (Homo sapiens)
LONP1 binds mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ALDH2 [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ALDH2 [mitochondrial matrix] (Homo sapiens)
LONP1 degrades mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ALDH2 [mitochondrial matrix] (Homo sapiens)
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ALDH2 transforms GTN to NO (Homo sapiens)
ALDH2 tetramer [mitochondrial matrix] (Homo sapiens)
ALDH2 [mitochondrial matrix] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Serotonin clearance from the synaptic cleft (Homo sapiens)
Metabolism of serotonin (Homo sapiens)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Homo sapiens)
ALDH2 tetramer [mitochondrial matrix] (Homo sapiens)
ALDH2 [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
4065146
Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations.
Kaiser, R
,
Jornvall, H
,
Hempel, J
Eur J Biochem
1985
18196
Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.
Greenfield, NJ
,
Pietruszko, R
Biochim Biophys Acta
1977
External Reference Information
External Reference
UniProt:P05091 ALDH2
Gene Names
ALDH2, ALDM
Chain
transit peptide:1-17, chain:18-517
Reference Genes
BioGPS Gene:217 ALDH2
COSMIC (genes):ALDH2 ALDH2
CTD Gene:217 ALDH2
dbSNP Gene:217 ALDH2
ENSEMBL:ENSG00000111275 ALDH2
HGNC:404 ALDH2
KEGG:hsa:217 ALDH2
Monarch:217 ALDH2
NCBI Gene:217 ALDH2
UCSC:P05091 ALDH2
Reference Transcript
RefSeq:NM_000690.3 ALDH2
RefSeq:NM_001204889.1 ALDH2
Other Identifiers
11715627_x_at
11746896_a_at
16757160
16757178
201425_PM_at
201425_at
217
2439266
32747_at
3361139
3432092
3432094
3432096
3432097
3432099
3432101
3432102
3432103
3432105
3432108
3432110
3432111
3432112
3432113
3432114
3432117
3432118
3432119
3432121
3432123
3432125
3432127
3432128
3432130
3432132
3432134
3432135
7958784
84527_at
A_14_P108452
A_23_P36745
A_23_P36753
GE61664
GE899092
GO:0003824
GO:0004029
GO:0004030
GO:0005739
GO:0005759
GO:0005975
GO:0006066
GO:0006068
GO:0008957
GO:0009055
GO:0016491
GO:0016620
GO:0016787
GO:0018937
GO:0043226
GO:0043878
GO:0046185
GO:0051287
GO:0070062
GO:0106435
GO:1903179
GO:1905627
HMNXSV003000936
HMNXSV003019489
ILMN_1793859
PH_hs_0033390
TC12000871.hg
TC12003212.hg
X05409_at
g4502032_3p_at
p3852
Participates
as a member of
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as a component of
ALDH2 tetramer [mitochondrial matrix] (Homo sapiens)
Inferred To
Aldh [mitochondrial matrix]
(Drosophila melanogaster)
ALDH2 [mitochondrial matrix]
(Bos taurus)
ALDH2 [mitochondrial matrix]
(Canis familiaris)
ALDH2 [mitochondrial matrix]
(Dictyostelium discoideum)
ALDH2 [mitochondrial matrix]
(Gallus gallus)
ALDH2 [mitochondrial matrix]
(Mus musculus)
ALDH2 [mitochondrial matrix]
(Rattus norvegicus)
ALDH2 [mitochondrial matrix]
(Saccharomyces cerevisiae)
ALDH2 [mitochondrial matrix]
(Schizosaccharomyces pombe)
ALDH2 [mitochondrial matrix]
(Sus scrofa)
aldh2.2 [mitochondrial matrix]
(Danio rerio)
Homologues of ALDH2 [mitochondrial matrix]
(Dictyostelium discoideum)
Homologues of ALDH2 [mitochondrial matrix]
(Saccharomyces cerevisiae)
aldh2 [mitochondrial matrix]
(Xenopus tropicalis)
hydA [mitochondrial matrix]
(Dictyostelium discoideum)
alh-1 [mitochondrial matrix]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
2595
OpenTargets
ENSG00000111275
ENSEMBL
ENST00000416293
,
ENSP00000403349
,
ENSG00000111275
,
ENSP00000261733
,
ENST00000261733
ZINC - Substances
ALDH2_HUMAN
ZINC - Biogenic
ALDH2_HUMAN
ZINC target
P05091
PRO
P05091
GlyGen
P05091
PDB
5L13
,
2VLE
,
2ONP
,
2ONM
,
2ONO
,
2ONN
,
3SZ9
,
1ZUM
,
8SHS
,
1O02
,
3N82
,
1NZZ
,
1O00
,
1O01
,
1O05
,
1O04
,
1NZX
,
3N83
,
1NZW
,
4KWG
,
4FR8
,
3N80
,
4FQF
,
3INJ
,
4KWF
,
8DR9
,
3INL
,
3N81
,
1CW3
ZINC - Metabolites
ALDH2_HUMAN
HPA
ENSG00000111275-ALDH2
GeneCards
ALDH2
Pharos - Targets
P05091
ZINC - Predictions - Purchasable
ALDH2_HUMAN
HMDB Protein
HMDBP00295
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02787 TF
6
TF [endoplasmic reticulum lumen]
(R-HSA-8956763)
p-TF [endoplasmic reticulum lumen]
(R-HSA-8957001)
apoTF [extracellular region]
(R-HSA-350754)
apoTF [endosome membrane]
(R-HSA-917974)
TF [secretory granule lumen]
(R-HSA-350704)
apoTF [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869140)
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:Q02252 ALDH6A1
1
ALDH6A1 [mitochondrial matrix]
(R-HSA-70890)
0.527
2
UniProt:P02675 FGB
5
FGB [extracellular region]
(R-HSA-140584)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
0.527
2
UniProt:P02647 APOA1
11
APOA1(25-266) [extracellular region]
(R-HSA-174720)
APOA1 [endoplasmic reticulum lumen]
(R-HSA-8956724)
p-APOA1 [endoplasmic reticulum lumen]
(R-HSA-8957081)
APOA1(25-266) [endocytic vesicle lumen]
(R-HSA-2239460)
Variant apolipoprotein AI [extracellular region]
(R-HSA-976865)
APOA1(25-266) [plasma membrane]
(R-HSA-216742)
APOA1(19-266) [extracellular region]
(R-HSA-264771)
APOA1(25-267) [endoplasmic reticulum lumen]
(R-HSA-174640)
APOA1(25-267) [early endosome]
(R-HSA-2429641)
APOA1(25-267) [cytosol]
(R-HSA-2395781)
APOA1(25-266) [secretory granule lumen]
(R-HSA-350761)
0.527
2
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