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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
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Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
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FAQ
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Citing us
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FGA [extracellular region]
Stable Identifier
R-HSA-140583
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
fibrinogen alpha chain
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Adhesion of integrin αIIbβ3 to fibrin network (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Interaction of integrin alphaXbeta2 with fibrin (Homo sapiens)
Integrin alphaXbeta2:fibrin multimer [plasma membrane] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
n fibrin monomers -> fibrin multimer (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
fibrin multimer [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
fibrin monomer [extracellular region] (Homo sapiens)
FGA [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02671 FGA
Gene Names
FGA
Chain
signal peptide:1-19, peptide:20-35, chain:36-866
Reference Genes
COSMIC (genes):FGA FGA
dbSNP Gene:2243 FGA
ENSEMBL:ENSG00000171560 FGA
Participates
as a component of
fibrin monomer [extracellular region] (Homo sapiens)
Other forms of this molecule
FGA(20-866) [platelet alpha granule lumen]
Variant fibrinogen alpha chain [extracellular region]
FGA(20-866) [extracellular region]
FGA [plasma membrane]
p-FGA [endoplasmic reticulum lumen]
FGA [endoplasmic reticulum lumen]
FGA(20-35) [extracellular region]
Inferred To
FGA [extracellular region]
(Gallus gallus)
FGA [extracellular region]
(Mus musculus)
FGA [extracellular region]
(Rattus norvegicus)
FGA [extracellular region]
(Sus scrofa)
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02679 FGG
5
FGG [extracellular region]
(R-HSA-140585)
FGG [endoplasmic reticulum lumen]
(R-HSA-8956692)
p-FGG [endoplasmic reticulum lumen]
(R-HSA-8956993)
FGG [plasma membrane]
(R-HSA-140918)
FGG [platelet alpha granule lumen]
(R-HSA-140922)
0.852
11
UniProt:P02675 FGB
5
FGB [extracellular region]
(R-HSA-140584)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
0.852
11
UniProt:Q8IXL6 FAM20C
1
FAM20C [endoplasmic reticulum lumen]
(R-HSA-8952276)
0.623
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.564
2
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.547
2
UniProt:Q99XV0 Q99XV0
0.524
2
UniProt:P02647 APOA1
11
APOA1(25-266) [extracellular region]
(R-HSA-174720)
APOA1 [endoplasmic reticulum lumen]
(R-HSA-8956724)
p-APOA1 [endoplasmic reticulum lumen]
(R-HSA-8957081)
APOA1(25-266) [endocytic vesicle lumen]
(R-HSA-2239460)
Variant apolipoprotein AI [extracellular region]
(R-HSA-976865)
APOA1(25-266) [plasma membrane]
(R-HSA-216742)
APOA1(19-266) [extracellular region]
(R-HSA-264771)
APOA1(25-267) [endoplasmic reticulum lumen]
(R-HSA-174640)
APOA1(25-267) [early endosome]
(R-HSA-2429641)
APOA1(25-267) [cytosol]
(R-HSA-2395781)
APOA1(25-266) [secretory granule lumen]
(R-HSA-350761)
0.483
2
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![FGA [extracellular region] icon](/icon/R-ICO-012722.svg){kind=icon}
