Reactome | AcK13-HIST1H2BJ [nucleoplasm]

AcK13-HIST1H2BJ [nucleoplasm]

Stable Identifier

R-HSA-4568662

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HATs acetylate histones (Homo sapiens)
    - CREBBP acetylates histone H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK13-replicative histone H2B [nucleoplasm] (Homo sapiens)
        
        Ack13-replicative histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
    - EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC10 deacetylates histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
    - HDAC3 containing complexes deacetylate histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
    - HDAC8 deacetylates histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - HCMV Infection (Homo sapiens)
    - HCMV Early Events (Homo sapiens)
      - Activation of Latent HCMV Genome (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
      - Delayed Early (DE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
      - Immediate Early (IE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
      - Transcriptional Activation of the HCMV Genome (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)
    - HCMV Late Events (Homo sapiens)
      - Late (L) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST1H2BJ [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06899 H2BC11

Gene Names

H2BC11, H2BFR, HIST1H2BJ

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:8970 H2BC11

CTD Gene:8970 H2BC11

dbSNP Gene:8970 H2BC11

ENSEMBL:ENSG00000124635 HIST1H2BJ

HGNC:4761 H2BC11

KEGG Gene (Homo sapiens):8970 H2BC11

Monarch:8970 H2BC11

NCBI Gene:8970 H2BC11

OMIM:615044 H2BC11

UCSC:P06899 H2BC11

Reference Transcript

RefSeq:NM_021058.3 H2BC11

Other Identifiers

0006400546

11741699_at

11741700_s_at

11741701_x_at

153_f_at

17016451

2946699

2946700

2946709

2946710

2946711

2946712

8124484

85177_at

8970

A_24_P359231

A_24_P55148

GE85150

GO:0000786

GO:0001530

GO:0002227

GO:0002376

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0006333

GO:0006334

GO:0006950

GO:0007165

GO:0008150

GO:0008289

GO:0010804

GO:0019731

GO:0022607

GO:0031640

GO:0032991

GO:0042742

GO:0043226

GO:0043505

GO:0046982

GO:0050829

GO:0050830

GO:0051276

GO:0061644

GO:0061844

GO:0065003

HMNXSV003001392

ILMN_1658702

PH_hs_0035577

TC06001385.hg

TC06001386.hg

X00088_at

Participates

as a member of

Other forms of this molecule

HIST1H2BJ [extracellular region]

Ub-HIST1H2BJ [nucleoplasm]

AcK-HIST1H2BJ [nucleoplasm]

AcK21-HIST1H2BJ [nucleoplasm]

AcK6-HIST1H2BJ [nucleoplasm]

AcK16-HIST1H2BJ [nucleoplasm]

Ub-121-HIST1H2BJ [nucleoplasm]

HIST1H2BJ [nucleoplasm]

Inferred To

H2B-V [nucleoplasm] (Gallus gallus)

H2B-VI [nucleoplasm] (Gallus gallus)

His2B [nucleoplasm] (Drosophila melanogaster)

si:ch211-113a14.22 [nucleoplasm] (Danio rerio)

AcK13-HIST1H2BB [nucleoplasm] (Danio rerio)

h2bc1 [nucleoplasm] (Danio rerio)

h2bc14 [nucleoplasm] (Xenopus tropicalis)

si:dkey-23a13.22 [nucleoplasm] (Danio rerio)

H2BC3 [nucleoplasm] (Bos taurus)

H2BC10 [nucleoplasm] (Canis familiaris)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Danio rerio)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Gallus gallus)

Modified Residues

Name

N6-acetyl-L-lysine at 13

Coordinate

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_066402.2

OpenTargets

ENSG00000124635

HPA

ENSG00000124635-H2BC11

GeneCards

P06899

Ensembl

ENST00000607124, ENSP00000476136, ENSG00000124635, ENSP00000342886, ENST00000339812

PRO

P06899

Pharos - Targets

P06899

PDB

6YOV, 5CPJ, 7K61, 6J4Y, 3W98, 5Y0D, 5AV8, 6INQ, 3W96, 3W97, 6T93, 6L49, 6R8Y, 3AZH, 6M44, 3AZL, 5Z30, 6J51, 3AFA, 7CCQ, 3AYW, 6V2K, 6JR0, 5VEY, 6LAB, 6IQ4, 5B31, 7COW, 5XF3, 7K60, 6JOU, 3WAA, 7CCR, 6KVD, 4CAY, 6LA2, 5Z23, 3W99, 5JRG, 6IR9, 5B0Z, 6J4W, 6KXV, 4YM5, 6LA9, 3WTP, 6J50, 3AZI, 5ZBX, 7D1Z, 6A5L, 6J4Z, 5AY8, 6A5U, 6R91, 3AV2, 6L9Z, 6E0C, 5B0Y, 7LYB, 7K5X, 3AZF, 5B32, 6A5R, 5XF4, 6HKT, 6R94, 6LER, 5AVC, 6IPU, 7K63, 3WA9, 6J4X, 6A5O, 5AVB, 7NL0, 4YM6, 7D20, 7C0M, 6T90, 5GXQ, 2RVQ, 6E0P, 6M3V, 5AV6, 5X7X, 6O1D, 7BY0, 3AN2, 3AZM, 5GSE, 5XF5, 6L4A, 3AZJ, 7LYC, 5B24, 5CPK, 5B33, 6R93, 6K1K, 5GTC, 3AZE, 6JXD, 5B2I, 5FUG, 5Y0C, 5CPI, 6LA8, 6A5P, 5B40, 3A6N, 3AZG, 3AZN, 6HTS, 5AV5, 6R8Z, 6USJ, 6K1I, 7LYA, 6R90, 4Z5T, 3AV1, 6K1J, 6JR1, 6A5T, 6R92, 3AZK, 7K5Y, 5AV9, 5B2J, 6BUZ

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