Reactome | FTO [nucleoplasm]

FTO [nucleoplasm]

Stable Identifier

R-HSA-8857715

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Alpha-ketoglutarate-dependent dioxygenase FTO ecNumber1.14.11.-/ecNumber, FTO_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9C0B1 FTO

Gene Names

FTO, KIAA1752

Chain

chain:1-505

Reference Genes

BioGPS Gene:79068 Q9C0B12

COSMIC (genes):FTO FTO

CTD Gene:79068 Q9C0B12

dbSNP Gene:79068 FTO

ENSEMBL:ENSG00000140718 FTO

HGNC:24678 Q9C0B12

KEGG:hsa:79068 Q9C0B12

Monarch:79068 Q9C0B12

NCBI Gene:79068 Q9C0B12

OMIM:610966 Q9C0B12

UCSC:Q9C0B1 Q9C0B12

Reference Transcript

RefSeq:NM_001080432.3 Q9C0B12

Participates

as a component of

FTO:Fe2+ [nucleoplasm] (Homo sapiens)

Inferred To

Fto [nucleoplasm] (Mus musculus)

Fto [nucleoplasm] (Rattus norvegicus)

fto [nucleoplasm] (Danio rerio)

fto [nucleoplasm] (Xenopus tropicalis)

FTO [nucleoplasm] (Bos taurus)

FTO [nucleoplasm] (Canis familiaris)

FTO [nucleoplasm] (Gallus gallus)

FTO [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001073901.1

OpenTargets

ENSG00000140718

ENSEMBL

ENSP00000418823, ENSP00000417422, ENST00000463855, ENSG00000140718, ENST00000460382, ENST00000431610, ENSP00000417843, ENSP00000415636, ENST00000471389

ZINC - Substances

FTO_HUMAN

ZINC target

Q9C0B1

PRO

Q9C0B1

GlyGen

Q9C0B1

PDB

4CXW, 6AK4, 4CXY, 5ZMD, 5F8P, 7CKK, 7E8Z, 5DAB, 4CXX, 4QKN, 7WCV, 4IE7, 3LFM, 8IT9, 6AKW, 4IE4, 4QHO, 4IE5, 4IDZ, 4ZS2, 6AEJ, 9KNI, 4IE6, 4ZS3, 4IE0

ZINC - Investigational

FTO_HUMAN

IntEnz

1.14.11.53

HPA

ENSG00000140718-FTO

GeneCards

FTO

Pharos - Targets

Q9C0B1

Orphanet

FTO

ZINC - Predictions - Purchasable

FTO_HUMAN

HMDB Protein

HMDBP12304

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.527	2
UniProt:Q6IPR3 TYW3	1	TYW3 [cytoplasm] (R-HSA-6782888)	0.527	2
UniProt:O95076 ALX3	1	ALX3 [nucleoplasm] (R-HSA-9858233)	0.527	2
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) SDC1 [Golgi lumen] (R-HSA-2054105) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) HS(5)-SDC1 [Golgi lumen] (R-HSA-2076290) HS(6)-SDC1 [Golgi lumen] (R-HSA-2076520) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314)	0.527	2

Cite Us!