Reactome | FGA [plasma membrane]

FGA [plasma membrane]

Stable Identifier

R-HSA-140916

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

fibrinogen alpha chain

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P02671 FGA

Gene Names

FGA

Chain

signal peptide:1-19, peptide:20-35, chain:36-866

Reference Genes

BioGPS Gene:2243 FGA

COSMIC (genes):FGA FGA

CTD Gene:2243 FGA

dbSNP Gene:2243 FGA

ENSEMBL:ENSG00000171560 FGA

HGNC:3661 FGA

KEGG:hsa:2243 FGA

Monarch:2243 FGA

NCBI Gene:2243 FGA

OMIM:134820 FGA

UCSC:P02671 FGA

Reference Transcript

Participates

as a component of

fibrin monomer [plasma membrane] (Homo sapiens)

Other forms of this molecule

FGA [extracellular region]

FGA(20-35) [extracellular region]

FGA(20-866) [extracellular region]

FGA(20-866) [platelet alpha granule lumen]

FGA [endoplasmic reticulum lumen]

p-FGA [endoplasmic reticulum lumen]

Variant fibrinogen alpha chain [extracellular region]

Inferred To

FGA [plasma membrane] (Gallus gallus)

FGA [plasma membrane] (Mus musculus)

FGA [plasma membrane] (Rattus norvegicus)

FGA [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_000499.1, NP_068657.1

OpenTargets

ENSG00000171560

ENSEMBL

ENST00000651975, ENSP00000385981, ENSG00000171560, ENSP00000498441, ENST00000403106

HPA

ENSG00000171560-FGA

GeneCards

FGA

PRO

P02671

Pharos - Targets

P02671

Orphanet

FGA

GlyGen

P02671

HMDB Protein

HMDBP13512

PDB

4F27, 3GHG, 2Z4E, 3E1I, 2XNX, 2XNY, 2A45, 2H43, 1RE4, 2HOD, 1FZD, 2OYH, 1RF0, 2FFD, 1RF1, 2OYI, 2HPC, 1N8E, 3HUS, 2Q9I, 1RE3, 3H32, 1N86, 1FZA, 1FZC, 1FZB, 2HLO, 5CFA, 1FPH, 1YCP, 1DM4, 1BBR, 3BVH, 1LTJ, 3AT0, 1FZG, 1FZE, 1FZF, 1LT9

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02679 FGG	5	FGG [extracellular region] (R-HSA-140585) FGG [plasma membrane] (R-HSA-140918) FGG [platelet alpha granule lumen] (R-HSA-140922) FGG [endoplasmic reticulum lumen] (R-HSA-8956692) p-FGG [endoplasmic reticulum lumen] (R-HSA-8956993)	0.852	11
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.852	11
UniProt:Q8IXL6 FAM20C	1	FAM20C [endoplasmic reticulum lumen] (R-HSA-8952276)	0.623	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.564	2
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.547	2
UniProt:Q99XV0 Q99XV0			0.524	2
UniProt:P02647 APOA1	11	APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-266) [secretory granule lumen] (R-HSA-350761)	0.483	2

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