Reactome | FGA [plasma membrane]

FGA [plasma membrane]

Stable Identifier

R-HSA-140916

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

fibrinogen alpha chain

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External Reference Information

External Reference

UniProt:P02671 FGA

Gene Names

FGA

Chain

signal peptide:1-19, peptide:20-35, chain:36-866

Reference Genes

BioGPS Gene:2243 FGA

COSMIC (genes):FGA FGA

CTD Gene:2243 FGA

dbSNP Gene:2243 FGA

ENSEMBL:ENSG00000171560 FGA

HGNC:3661 FGA

KEGG Gene (Homo sapiens):2243 FGA

Monarch:2243 FGA

NCBI Gene:2243 FGA

OMIM:134820 FGA

UCSC:P02671 FGA

Reference Transcript

Other Identifiers

0002360161

0002360717

0003850594

11731398_a_at

11731399_s_at

11749963_a_at

11757349_a_at

11757350_x_at

16776

16980836

1BBR

1DM4

1FPH

1FZA

1FZB

1FZC

1FZD

1FZE

1FZF

1FZG

1LT9

1LTJ

1N86

1N8E

1RE3

1RE4

1RF0

1RF1

1YCP

205649_s_at

205650_s_at

2243

2790625

2790627

2790628

2790629

2790630

2790631

2790632

2790633

2790634

2790635

2790636

2790637

2790638

2790639

2790640

2790641

2790642

2790643

2790644

2790645

2790646

2790647

2790648

2790649

2A45

2FFD

2H43

2HLO

2HOD

2HPC

2OYH

2OYI

2Q9I

2XNX

2XNY

2Z4E

38825_at

3AT0

3BVH

3E1I

3GHG

3H32

3HUS

4F27

51370

5CFA

8103311

A0A087WUA0

A_23_P375372

A_23_P44274

A_24_P282251

A_32_P42842

AAA17055

AAA17056

AAA52426

AAA52427

AAA52428

AAA52444

AAC97142

AAC97143

AAH98280

AAH99706

AAH99720

AAI01936

AAK31372

AAK31373

AF361104

AK290559

BAF83248

BC098280

BC099706

BC099720

BC101935

CAB016776

CCDS3787

CCDS47152

CH471056

EAX04925

EAX04926

EAX04927

EAX04928

ENSG00000171560

ENSP00000385981

ENSP00000498441

ENST00000302053.7

ENST00000403106

ENST00000403106.7

ENST00000651975

EntrezGene:2243

EntrezGene:FGA

FGA

FGA-201

FGA-203

g11761627_3p_s_at

g11761628_3p_s_at

GE58040

GE79857

GO:0002224

GO:0002250

GO:0002376

GO:0002576

GO:0003013

GO:0003674

GO:0005102

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005577

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005788

GO:0005886

GO:0006464

GO:0006810

GO:0006950

GO:0007155

GO:0007160

GO:0007165

GO:0007267

GO:0007596

GO:0007599

GO:0008150

GO:0008219

GO:0009897

GO:0009986

GO:0015031

GO:0016192

GO:0022607

GO:0030168

GO:0030198

GO:0031012

GO:0031091

GO:0031093

GO:0031410

GO:0031639

GO:0032991

GO:0034116

GO:0034622

GO:0042730

GO:0043152

GO:0043167

GO:0043226

GO:0043687

GO:0044267

GO:0045087

GO:0045907

GO:0045921

GO:0046872

GO:0050714

GO:0050839

GO:0051258

GO:0051592

GO:0051604

GO:0062023

GO:0065003

GO:0070062

GO:0070374

GO:0070527

GO:0072377

GO:0072378

GO:0072562

GO:0090277

GO:1900026

GO:1902042

GO:1903561

GO:2000352

HGNC:3661

HPA051370

HPA064755

ILMN_1656487

ILMN_1659947

ILMN_1779017

ILMN_2280203

ILMN_2381945

IPR002181

IPR012290

IPR020837

IPR021996

IPR036056

J00127

J00128

K02272

LRG_557

M26878

M58569

M58569_s_at

M64982

MIM:105200

MIM:134820

MIM:202400

MIM:616004

NM_000508

NM_021871

NP_000499

NP_068657

PF00147

PF08702

PF12160

PH_hs_0028209

SM00186

SM01212

TC04001662.hg

TC04002793.hg

UPI000002A9B1

UPI000012A75A

Participant Of

hasComponent

fibrin monomer [plasma membrane]

Other forms of this molecule

Variant fibrinogen alpha chain [extracellular region]

FGA(20-866) [extracellular region]

FGA(20-866) [platelet alpha granule lumen]

FGA(20-35) [extracellular region]

p-FGA [endoplasmic reticulum lumen]

FGA [endoplasmic reticulum lumen]

FGA [extracellular region]

Inferred To

FGA [plasma membrane] (Mus musculus)

FGA [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_068657.1, NP_000499.1

OpenTargets

ENSG00000171560

GeneCards

P02671

PRO

P02671

Orphanet

16040

PDB

1N86, 1FZG, 2FFD, 3BVH, 4F27, 2Z4E, 1FZC, 1RE4, 1RE3, 1FZF, 2HPC, 2OYI, 2A45, 1RF1, 1LTJ, 2HLO, 1RF0, 3GHG, 3HUS, 1FZB, 1BBR, 2XNY, 1FZE, 2OYH, 2Q9I, 1DM4, 2H43, 1FPH, 1FZA, 1N8E, 3AT0, 5CFA, 3H32, 3E1I, 2XNX, 1FZD, 1LT9, 2HOD, 1YCP

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02679 FGG	5	p-FGG [endoplasmic reticulum lumen] (R-HSA-8956993) FGG [platelet alpha granule lumen] (R-HSA-140922) FGG [endoplasmic reticulum lumen] (R-HSA-8956692) FGG [plasma membrane] (R-HSA-140918) FGG [extracellular region] (R-HSA-140585)	0.802	5
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB [extracellular region] (R-HSA-140584)	0.802	5
UniProt:Q8IXL6 FAM20C	1	FAM20C [endoplasmic reticulum lumen] (R-HSA-8952276)	0.623	2
UniProt:P02647 APOA1	11	Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) APOA1(25-266) [secretory granule lumen] (R-HSA-350761) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-266) [plasma membrane] (R-HSA-216742) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1(25-267) [early endosome] (R-HSA-2429641)	0.564	2
UniProt:Q99XV0 Q99XV0			0.524	2