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Variant fibrinogen alpha chain [extracellular region]
Stable Identifier
R-HSA-976905
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Amyloid fibrils have additional components (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Systemic amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Variant fibrinogen alpha chain fibril [extracellular region] (Homo sapiens)
Variant fibrinogen alpha chain [extracellular region] (Homo sapiens)
Amyloid fibrils [plasma membrane] (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Systemic amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Variant fibrinogen alpha chain fibril [extracellular region] (Homo sapiens)
Variant fibrinogen alpha chain [extracellular region] (Homo sapiens)
Amyloid precursor proteins form ordered fibrils (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Systemic amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Variant fibrinogen alpha chain fibril [extracellular region] (Homo sapiens)
Variant fibrinogen alpha chain [extracellular region] (Homo sapiens)
Amyloid fibril monomers [extracellular region] (Homo sapiens)
Systemic amyloid fibril monomers [extracellular region] (Homo sapiens)
Variant fibrinogen alpha chain [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
8097946
Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain
Wheeler, G
,
Liepnieks, J
,
Correa, R
,
Benson, MD
,
Uemichi, T
Nat Genet
1993
External Reference Information
External Reference
UniProt:P02671 FGA
Gene Names
FGA
Chain
signal peptide:1-19, peptide:20-35, chain:36-866
Reference Genes
BioGPS Gene:2243 FGA
COSMIC (genes):FGA FGA
CTD Gene:2243 FGA
dbSNP Gene:2243 FGA
ENSEMBL:ENSG00000171560 FGA
HGNC:3661 FGA
KEGG:hsa:2243 FGA
Monarch:2243 FGA
NCBI Gene:2243 FGA
OMIM:134820 FGA
UCSC:P02671 FGA
Reference Transcript
RefSeq:NM_000508.5 FGA
RefSeq:NM_021871.4 FGA
Participates
as a member of
Systemic amyloid fibril monomers [extracellular region] (Homo sapiens)
as a repeated unit of
Variant fibrinogen alpha chain fibril [extracellular region] (Homo sapiens)
Other forms of this molecule
FGA [extracellular region]
FGA(20-35) [extracellular region]
FGA [endoplasmic reticulum lumen]
p-FGA [endoplasmic reticulum lumen]
FGA(20-866) [platelet alpha granule lumen]
FGA(20-866) [extracellular region]
FGA [plasma membrane]
Modified Residues
Name
L-glutamine 573 replaced with unknown
Coordinate
573
PsiMod
L-glutamine removal [MOD:01637]
A protein modification that effectively removes or replaces an L-glutamine.
Cross References
RefSeq
NP_000499.1
,
NP_068657.1
OpenTargets
ENSG00000171560
ENSEMBL
ENSP00000498441
,
ENSG00000171560
,
ENSP00000385981
,
ENST00000403106
,
ENST00000651975
HPA
ENSG00000171560-FGA
GeneCards
FGA
PRO
P02671
Pharos - Targets
P02671
Orphanet
FGA
GlyGen
P02671
HMDB Protein
HMDBP13512
PDB
3HUS
,
3H32
,
1N86
,
2Q9I
,
1RE3
,
5CFA
,
2HPC
,
1N8E
,
1FZD
,
1FZC
,
2HLO
,
1FZA
,
1FZB
,
3AT0
,
1BBR
,
3BVH
,
1LT9
,
1FZE
,
1FZF
,
1FZG
,
1DM4
,
1LTJ
,
4F27
,
1YCP
,
3GHG
,
3E1I
,
2XNX
,
2Z4E
,
1FPH
,
2XNY
,
2OYH
,
1RF1
,
2HOD
,
2A45
,
2H43
,
2OYI
,
1RF0
,
1RE4
,
2FFD
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02675 FGB
5
FGB [extracellular region]
(R-HSA-140584)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB [plasma membrane]
(R-HSA-140917)
0.852
11
UniProt:P02679 FGG
5
FGG [extracellular region]
(R-HSA-140585)
FGG [endoplasmic reticulum lumen]
(R-HSA-8956692)
p-FGG [endoplasmic reticulum lumen]
(R-HSA-8956993)
FGG [platelet alpha granule lumen]
(R-HSA-140922)
FGG [plasma membrane]
(R-HSA-140918)
0.852
11
UniProt:Q8IXL6 FAM20C
1
FAM20C [endoplasmic reticulum lumen]
(R-HSA-8952276)
0.623
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.564
2
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.547
2
UniProt:Q99XV0 Q99XV0
0.524
2
UniProt:P02647 APOA1
11
APOA1 [endoplasmic reticulum lumen]
(R-HSA-8956724)
p-APOA1 [endoplasmic reticulum lumen]
(R-HSA-8957081)
APOA1(25-266) [extracellular region]
(R-HSA-174720)
APOA1(25-266) [endocytic vesicle lumen]
(R-HSA-2239460)
Variant apolipoprotein AI [extracellular region]
(R-HSA-976865)
APOA1(25-266) [plasma membrane]
(R-HSA-216742)
APOA1(19-266) [extracellular region]
(R-HSA-264771)
APOA1(25-267) [endoplasmic reticulum lumen]
(R-HSA-174640)
APOA1(25-267) [early endosome]
(R-HSA-2429641)
APOA1(25-267) [cytosol]
(R-HSA-2395781)
APOA1(25-266) [secretory granule lumen]
(R-HSA-350761)
0.483
2
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