Reactome | LETM1 [endoplasmic reticulum membrane]

LETM1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9714759

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

LETM1 and EF-hand domain-containing protein 1, mitochondrial, LETM1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOG GTPase cycle (Homo sapiens)
        
        RHOG binds effectors at the ER membrane (Homo sapiens)
        
        RHOG endoplasmic reticulum effectors [endoplasmic reticulum membrane] (Homo sapiens)
        
        LETM1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        RHOG:GTP:RHOG endoplasmic reticulum effectors [endoplasmic reticulum membrane] (Homo sapiens)
        
        RHOG endoplasmic reticulum effectors [endoplasmic reticulum membrane] (Homo sapiens)
        
        LETM1 [endoplasmic reticulum membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
22331352	Endoplasmic reticulum potassium-hydrogen exchanger and small conductance calcium-activated potassium channel activities are essential for ER calcium uptake in neurons and cardiomyocytes Veksler, V, Kaasik, A, Ventura-Clapier, R, Liiv, J, Kuum, M	J Cell Sci	2012

External Reference Information

External Reference

UniProt:O95202 LETM1

Gene Names

LETM1

Chain

transit peptide:1-115, chain:116-739

Reference Genes

BioGPS Gene:3954 LETM1

COSMIC (genes):LETM1 LETM1

CTD Gene:3954 LETM1

dbSNP Gene:3954 LETM1

ENSEMBL:ENSG00000168924 LETM1

HGNC:6556 LETM1

KEGG:hsa:3954 LETM1

Monarch:3954 LETM1

NCBI Gene:3954 LETM1

OMIM:604407 LETM1

UCSC:O95202 LETM1

Reference Transcript

RefSeq:NM_012318.2 LETM1

Other Identifiers

11725207_at

11725208_at

11725209_at

11762092_a_at

16973602

218939_PM_at

218939_at

222006_3p_at

222006_PM_at

222006_at

233439_PM_at

233439_at

2757429

2757430

2757431

2757432

2757433

2757434

2757435

2757436

2757437

2757438

2757439

2757442

2757443

2757444

2757445

2757446

2757447

2757448

2757454

2757455

2757456

2757457

2757458

2757459

2757463

2757464

2757465

2757466

2757467

2757468

2757472

2757473

2757474

2757478

2757479

2757480

3843707

3843709

3843730

3954

72568_at

73120_at

8098924

84499_at

87591_at

89898_at

89900_at

A_23_P94998

GE79401

GO:0005215

GO:0005509

GO:0005515

GO:0005739

GO:0005743

GO:0006813

GO:0006816

GO:0006851

GO:0007005

GO:0007007

GO:0015297

GO:0015369

GO:0030003

GO:0034214

GO:0042407

GO:0043022

GO:0043226

GO:0046872

GO:0051260

GO:0051560

GO:0051562

GO:0055085

GO:0061024

GO:0065003

GO:0099093

GO:0140141

GO:1900069

GO:1902600

HMNXSV003017819

Hs.120165.1.A1_3p_at

Hs.120165.1.A1_3p_x_at

Hs.272313.0.S1_3p_at

ILMN_1710668

PH_hs_0006631

PH_hs_0040671

TC04000970.hg

g6912481_3p_at

Participates

as a candidate of

RHOG endoplasmic reticulum effectors [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

LETM1 [mitochondrial inner membrane]

Inferred To

LETM1 [endoplasmic reticulum membrane] (Bos taurus)

LETM1 [endoplasmic reticulum membrane] (Canis familiaris)

LETM1 [endoplasmic reticulum membrane] (Gallus gallus)

LETM1 [endoplasmic reticulum membrane] (Mus musculus)

LETM1 [endoplasmic reticulum membrane] (Rattus norvegicus)

LETM1 [endoplasmic reticulum membrane] (Sus scrofa)

LETM1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

3025

ENSEMBL

ENSP00000305653, ENST00000302787

OpenTargets

ENSG00000168924

HPA

ENSG00000168924-LETM1

PRO

O95202

Pharos - Targets

O95202

GlyGen

O95202

Orphanet

LETM1

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.556	3
UniProt:P04798 CYP1A1	1	CYP1A1 [endoplasmic reticulum membrane] (R-HSA-52623)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.527	2