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UBE2T [nucleoplasm]
Stable Identifier
R-HSA-420942
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
UBE2T [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
UBE2T [nucleoplasm] (Homo sapiens)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
UBE2T [nucleoplasm] (Homo sapiens)
UBE2T [nucleoplasm] (Homo sapiens)
Monoubiquitination of FANCD2:FANCI (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
UBE2T [nucleoplasm] (Homo sapiens)
The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
UBE2T [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
UBE2T [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
UBE2T [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPD8 UBE2T
Gene Names
UBE2T, HSPC150, PIG50
Chain
chain:1-197
Reference Genes
BioGPS Gene:29089 UBE2T
COSMIC (genes):UBE2T UBE2T
CTD Gene:29089 UBE2T
dbSNP Gene:29089 UBE2T
ENSEMBL:ENSG00000077152 UBE2T
ENSEMBL_homo_sapiens_GENE:ENSG00000077152.12 UBE2T
HGNC:25009 UBE2T
KEGG Gene (Homo sapiens):29089 UBE2T
Monarch:29089 UBE2T
NCBI Gene:29089 UBE2T
OMIM:610538 UBE2T
UCSC:Q9NPD8 UBE2T
Reference Transcript
RefSeq:NM_014176.3 UBE2T
RefSeq:NM_001310326.1 UBE2T
Other Identifiers
11729158_at
16698023
223229_PM_at
223229_at
2451201
2451202
2451205
2451208
2451210
2451214
2451215
2451216
2451220
2451221
29089
45803_at
7923426
A_23_P115482
GE58567
GO:0000166
GO:0000209
GO:0003682
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0006281
GO:0006513
GO:0006974
GO:0016567
GO:0016740
GO:0031625
GO:0032446
GO:0035519
GO:0036211
GO:0043226
GO:0044314
GO:0051865
GO:0061631
GO:0070534
GO:0070936
GO:0070979
GO:0085020
GO:0140096
HMNXSV003033690
ILMN_1711470
PH_hs_0000530
TC01003702.hg
g7416119_3p_at
Participates
as a member of
E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
as a component of
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
as an input of
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
Other forms of this molecule
Ub-C86-UBE2T [nucleoplasm]
MonoUb-K91,K182-UBE2T [nucleoplasm]
Inferred To
Ghost homologue of UBE2T [nucleoplasm]
(Canis familiaris)
Ube2t [nucleoplasm]
(Mus musculus)
Ube2t [nucleoplasm]
(Rattus norvegicus)
UBE2T [nucleoplasm]
(Bos taurus)
UBE2T [nucleoplasm]
(Dictyostelium discoideum)
UBE2T [nucleoplasm]
(Gallus gallus)
UBE2T [nucleoplasm]
(Sus scrofa)
ube2t [nucleoplasm]
(Danio rerio)
uev-3 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001297255.1
,
NP_054895.1
OpenTargets
ENSG00000077152
GeneCards
Q9NPD8
HPA
ENSG00000077152-UBE2T
Ensembl
ENSG00000077152
,
ENST00000699423
,
ENST00000646651
,
ENSP00000514379
,
ENSP00000494957
PRO
Q9NPD8
Pharos - Targets
Q9NPD8
Orphanet
23270
HMDB Protein
HMDBP11994
PDB
7KZR
,
8JUC
,
7KZS
,
5OJJ
,
7KZT
,
6R75
,
8JVE
,
8JVD
,
8JVL
,
7KZV
,
1YH2
,
4CCG
,
5NGZ
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NW38-1 FANCL
0.558
3
UniProt:P62879 GNB2
4
GNB2 [cytosol]
(R-HSA-6814421)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
0.556
3
UniProt:P02675 FGB
5
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [extracellular region]
(R-HSA-140584)
0.527
2
UniProt:Q15078 CDK5R1
4
MyrG-CDK5R1(2-307) [plasma membrane]
(R-HSA-421083)
CDK5R1(99-307) [nucleoplasm]
(R-HSA-6805262)
CDK5R1(99-307) [cytosol]
(R-HSA-8863415)
MyrG-CDK5R1(2-98) [plasma membrane]
(R-HSA-8863400)
0.527
2
UniProt:O43482 OIP5
1
OIP5 [nucleoplasm]
(R-HSA-606286)
0.527
2
UniProt:Q8NCR3 MFI
0.527
2
UniProt:Q9NRM2 ZN277
0.527
2
UniProt:P29084 GTF2E2
1
GTF2E2 [nucleoplasm]
(R-HSA-65563)
0.527
2
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:Q8NB91 FANCB
2
FANCB [nucleoplasm]
(R-HSA-419528)
FANCB [cytosol]
(R-HSA-420791)
0.527
2
UniProt:O95376 ARIH2
1
ARIH2 [cytosol]
(R-HSA-975987)
0.488
2
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