Reactome | Ub-C86-UBE2T [nucleoplasm]

Ub-C86-UBE2T [nucleoplasm]

Stable Identifier

R-HSA-8864217

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 T ecNumber evidence="9"2.3.2.23/ecNumber, UBE2T_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-C86-UBE2T [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NPD8 UBE2T

Gene Names

UBE2T, HSPC150, PIG50

Chain

chain:1-197

Reference Genes

BioGPS Gene:29089 UBE2T

COSMIC (genes):UBE2T UBE2T

CTD Gene:29089 UBE2T

dbSNP Gene:29089 UBE2T

ENSEMBL:ENSG00000077152 UBE2T

ENSEMBL_homo_sapiens_GENE:ENSG00000077152.12 UBE2T

HGNC:25009 UBE2T

KEGG Gene (Homo sapiens):29089 UBE2T

Monarch:29089 UBE2T

NCBI Gene:29089 UBE2T

OMIM:610538 UBE2T

UCSC:Q9NPD8 UBE2T

Reference Transcript

Other Identifiers

11729158_at

16698023

223229_PM_at

223229_at

2451201

2451202

2451205

2451208

2451210

2451214

2451215

2451216

2451220

2451221

29089

45803_at

7923426

A_23_P115482

GE58567

GO:0000166

GO:0000209

GO:0003682

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0006281

GO:0006513

GO:0006974

GO:0016567

GO:0016740

GO:0031625

GO:0032446

GO:0035519

GO:0036211

GO:0043226

GO:0044314

GO:0051865

GO:0061631

GO:0070534

GO:0070936

GO:0070979

GO:0085020

GO:0140096

HMNXSV003033690

ILMN_1711470

PH_hs_0000530

TC01003702.hg

g7416119_3p_at

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

UBE2T [nucleoplasm]

MonoUb-K91,K182-UBE2T [nucleoplasm]

Inferred To

Ube2t [nucleoplasm] (Mus musculus)

Ube2t [nucleoplasm] (Rattus norvegicus)

UBE2T [nucleoplasm] (Bos taurus)

UBE2T [nucleoplasm] (Sus scrofa)

ube2t [nucleoplasm] (Danio rerio)

uev-3 [nucleoplasm] (Caenorhabditis elegans)

Ub-C86-UBE2T [nucleoplasm] (Dictyostelium discoideum)

Ub-C86-UBE2T [nucleoplasm] (Gallus gallus)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 86

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_001297255.1, NP_054895.1

OpenTargets

ENSG00000077152

HPA

ENSG00000077152-UBE2T

GeneCards

Q9NPD8

Ensembl

ENSP00000514379, ENST00000699423, ENST00000646651, ENSP00000494957, ENSG00000077152

PRO

Q9NPD8

Pharos - Targets

Q9NPD8

Orphanet

23270

HMDB Protein

HMDBP11994

PDB

4CCG, 7KZT, 8JVL, 1YH2, 5NGZ, 7KZR, 5OJJ, 7KZV, 7KZS, 8JVE, 6R75

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NW38-1 FANCL			0.558	3
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.556	3
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [extracellular region] (R-HSA-140584)	0.527	2
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.527	2
UniProt:Q8NCR3 MFI			0.527	2
UniProt:Q9NRM2 ZN277			0.527	2
UniProt:P29084 GTF2E2	1	GTF2E2 [nucleoplasm] (R-HSA-65563)	0.527	2
UniProt:Q15078 CDK5R1	4	MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:Q8NB91 FANCB	2	FANCB [nucleoplasm] (R-HSA-419528) FANCB [cytosol] (R-HSA-420791)	0.527	2
UniProt:O95376 ARIH2	1	ARIH2 [cytosol] (R-HSA-975987)	0.488	2