Reactome | FGB [extracellular region]

FGB [extracellular region]

Stable Identifier

R-HSA-140584

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

fibrinogen beta chain

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Signaling by BRAF and RAF1 fusions (Homo sapiens)
      - Dissociation of BRAF/RAF fusion complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Signaling by RAF1 mutants (Homo sapiens)
      - Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
        
        activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
        
        activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Signaling by RAS mutants (Homo sapiens)
      - Signaling downstream of RAS mutants (Homo sapiens)
        
        Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Signaling by high-kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Dissociation of high activity BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Dissociation of moderate activity BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)

Hemostasis (Homo sapiens)

- Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
  - Common Pathway of Fibrin Clot Formation (Homo sapiens)
    - factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)
      - fibrin multimer [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Homo sapiens)
      - fibrin multimer [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
      - fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - n fibrin monomers -> fibrin multimer (Homo sapiens)
      - fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - fibrin multimer [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
- Platelet activation, signaling and aggregation (Homo sapiens)
  - Platelet Aggregation (Plug Formation) (Homo sapiens)
    - Integrin signaling (Homo sapiens)
      - Autophosphorylation of PTK2 at Y397 (Homo sapiens)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Autophosphorylation of SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
        
        Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Recruitment of GRB2 to p-PTK2 (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Phosphorylation of pPTK2 by SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Release of CSK from SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - SYK activation by SRC (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - SYK binds to integrin alphaIIb beta3 (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Translocation of PTK2 to Focal complexes (Homo sapiens)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
        
        Crk binding to p130cas (Homo sapiens)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Integrin signaling (Homo sapiens)
  - Autophosphorylation of PTK2 at Y397 (Homo sapiens)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - Autophosphorylation of SRC (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
    - Focal complex [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
    - Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Recruitment of GRB2 to p-PTK2 (Homo sapiens)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
    - Focal complex [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
      - fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - Phosphorylation of pPTK2 by SRC (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - Release of CSK from SRC (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - SYK activation by SRC (Homo sapiens)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - SYK binds to integrin alphaIIb beta3 (Homo sapiens)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - Translocation of PTK2 to Focal complexes (Homo sapiens)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
  - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
    - Crk binding to p130cas (Homo sapiens)
      - CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
    - Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Dissociation of RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        RAF phosphorylates MAP2K dimer (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        fibrin monomer [extracellular region] (Homo sapiens)
        
        FGB [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02675 FGB

Gene Names

FGB

Chain

signal peptide:1-30, peptide:31-44, chain:45-491

Reference Genes

BioGPS Gene:2244 FGB

COSMIC (genes):FGB FGB

CTD Gene:2244 FGB

dbSNP Gene:2244 FGB

ENSEMBL:ENSG00000171564 FGB

ENSEMBL:ENSG00000171564.12 FGB

HGNC:3662 FGB

KEGG Gene (Homo sapiens):2244 FGB

Monarch:2244 FGB

NCBI Gene:2244 FGB

OMIM:134830 FGB

Reference Transcript

Other Identifiers

11715628_a_at

11746819_a_at

11755934_x_at

11758728_at

16971643

204988_PM_at

204988_at

216238_PM_s_at

216238_s_at

2244

2748550

2748554

2748555

2748556

2748557

2748560

2748562

2748564

2748565

2748566

2748567

2748568

2748569

2748570

37019_at

47589_at

63760_at

78341_at

8097910

A_14_P100691

A_23_P136125

GE62817

GO:0002250

GO:0002376

GO:0003013

GO:0005102

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005577

GO:0005615

GO:0005783

GO:0005886

GO:0005938

GO:0007155

GO:0007160

GO:0007596

GO:0007599

GO:0009897

GO:0009986

GO:0012501

GO:0016192

GO:0023052

GO:0030154

GO:0030168

GO:0030312

GO:0031012

GO:0031091

GO:0031093

GO:0031410

GO:0031639

GO:0034116

GO:0042060

GO:0042730

GO:0043152

GO:0043226

GO:0044320

GO:0045087

GO:0045202

GO:0045907

GO:0045921

GO:0048856

GO:0050714

GO:0050839

GO:0051087

GO:0051258

GO:0051592

GO:0051604

GO:0062023

GO:0065003

GO:0070062

GO:0070374

GO:0070527

GO:0071347

GO:0072378

GO:0072562

GO:0090277

GO:0098542

GO:0110165

GO:1900026

GO:1902042

GO:1903561

GO:2000352

HMNXSV003033495

Hs.7645.1.S1_3p_a_at

Hs.7645.1.S1_3p_x_at

ILMN_1678049

ILMN_2114972

J00129_at

PH_hs_0023603

TC04000777.hg

g11761630_3p_at

Participates

as a component of

fibrin monomer [extracellular region] (Homo sapiens)

Other forms of this molecule

FGB(31-491) [platelet alpha granule lumen]

FGB(31-491) [extracellular region]

FGB [plasma membrane]

FGB(31-44) [extracellular region]

Inferred To

FGB [extracellular region] (Gallus gallus)

FGB [extracellular region] (Sus scrofa)

Fgb [extracellular region] (Mus musculus)

Fgb [extracellular region] (Rattus norvegicus)

wu:fa55c11 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_005132.2, NP_001171670.1

OpenTargets

ENSG00000171564

GeneCards

P02675

HPA

ENSG00000171564-FGB

Ensembl

ENSG00000171564, ENSP00000306099, ENST00000302068

PRO

P02675

Pharos - Targets

P02675

Orphanet

16041

HMDB Protein

HMDBP13514

PDB

2XNY, 1FZG, 2HLO, 6V13, 6ATZ, 1N8E, 3HUS, 2HPC, 6V0Y, 3H32, 1FZF, 2H43, 2XNX, 6V15, 1RF1, 3BVH, 1RF0, 1N86, 6V18, 1FZE, 6V19, 1FZC, 2OYI, 2OYH, 2FFD, 2A45, 1FZA, 6BIJ, 6BIL, 1FZB, 6V1A, 2HOD, 1LTJ, 2Q9I, 3GHG, 1RE3, 1RE4, 2Z4E, 1LT9, 3E1I

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02671 FGA	8	FGA(20-866) [platelet alpha granule lumen] (R-HSA-140920) FGA(20-866) [extracellular region] (R-HSA-140841) Variant fibrinogen alpha chain [extracellular region] (R-HSA-976905) p-FGA [endoplasmic reticulum lumen] (R-HSA-8957043) FGA [endoplasmic reticulum lumen] (R-HSA-8956714) FGA [plasma membrane] (R-HSA-140916) FGA(20-35) [extracellular region] (R-HSA-140867) FGA [extracellular region] (R-HSA-140583)	0.852	11
UniProt:P27958-PRO_0000037566			0.543	4

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