Reactome | DIS3 [nucleoplasm]

DIS3 [nucleoplasm]

Stable Identifier

R-HSA-6791517

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Exosome complex exonuclease RRP44 ecNumber3.1.13.-/ecNumber ecNumber3.1.26.-/ecNumber, RRP44_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y2L1 DIS3

Gene Names

DIS3, KIAA1008, RRP44

Chain

chain:1-958

Reference Genes

BioGPS Gene:22894 DIS3

COSMIC (genes):DIS3 DIS3

CTD Gene:22894 DIS3

dbSNP Gene:22894 DIS3

ENSEMBL:ENSG00000083520 DIS3

HGNC:20604 DIS3

KEGG Gene (Homo sapiens):22894 DIS3

Monarch:22894 DIS3

NCBI Gene:22894 DIS3

OMIM:607533 DIS3

UCSC:Q9Y2L1 DIS3

Reference Transcript

Other Identifiers

0004760072

11726622_a_at

11726623_a_at

11748232_a_at

16779725

214194_at

218362_3p_s_at

218362_s_at

222607_s_at

22894

234660_s_at

234757_at

236560_at

3517586

3517588

3517590

3517592

3517593

3517595

3517596

3517597

3517598

3517599

3517600

3517601

3517602

3517603

3517604

3517605

3517606

3517608

3517610

3517611

3517613

3517616

3517617

3517618

3517619

3517620

3517621

3517622

3517623

3517624

3517625

3517626

3517627

3517628

3517629

3517630

3517633

3517634

3517635

3517636

40633_at

7971965

7971967

84273_at

A_23_P412613

A_23_P48416

A_24_P219024

A_24_P395317

A_32_P205522

A_33_P3395502

GE53651

GO:0000175

GO:0000176

GO:0000177

GO:0000178

GO:0003674

GO:0003723

GO:0004518

GO:0004519

GO:0004527

GO:0004540

GO:0005085

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006364

GO:0008150

GO:0009056

GO:0016020

GO:0016075

GO:0016787

GO:0019899

GO:0032991

GO:0034641

GO:0034655

GO:0042254

GO:0043226

GO:0043488

GO:0043928

GO:0050790

GO:0071034

GO:0090305

GO:0090501

GO:0090503

HMNXSV003013894

HMNXSV003020865

Hs.179566.0.S1_3p_at

Hs.323346.0.S1_3p_a_at

Hs.323346.1.S1_3p_a_at

Hs.326725.0.A1_3p_at

Hs.59661.0.S1_3p_at

ILMN_1799796

PH_hs_0016095

TC13000727.hg

TC13001569.hg

U79246_at

g7662443_3p_x_at

This entity regulates

Positively

12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)

Other forms of this molecule

DIS3 [cytosol]

Inferred To

dis3 [nucleoplasm] (Danio rerio)

dis3 [nucleoplasm] (Schizosaccharomyces pombe)

dis-3 [nucleoplasm] (Caenorhabditis elegans)

Dis3 [nucleoplasm] (Drosophila melanogaster)

Dis3 [nucleoplasm] (Mus musculus)

Dis3 [nucleoplasm] (Rattus norvegicus)

DIS3 [nucleoplasm] (Canis familiaris)

DIS3 [nucleoplasm] (Saccharomyces cerevisiae)

DIS3 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001121698.1, NP_055768.3

OpenTargets

ENSG00000083520

HPA

ENSG00000083520-DIS3

GeneCards

Q9Y2L1

Ensembl

ENST00000377780, ENSG00000083520, ENSP00000366997, ENSP00000367011, ENST00000377767

PRO

Q9Y2L1

Pharos - Targets

Q9Y2L1

GlyGen

Q9Y2L1

Orphanet

26868

PDB

6D6R, 6D6Q, 6H25

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.738	4
UniProt:Q9NQT5 EXOSC3	2	EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [cytosol] (R-HSA-430017)	0.669	3
UniProt:Q96B26 EXOSC8	2	EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.547	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q13868 EXOSC2	2	EXOSC2 [nucleoplasm] (R-HSA-6791582) EXOSC2 [cytosol] (R-HSA-429999)	0.462	2
UniProt:Q9NPD3 EXOSC4	2	EXOSC4 [nucleoplasm] (R-HSA-6791503) EXOSC4 [cytosol] (R-HSA-430013)	0.462	2