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AcK21-HIST1H2BJ [nucleoplasm]
Stable Identifier
R-HSA-4568671
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
AcK-histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC10 deacetylates histone (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex deacetylate histones (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
HDAC3 containing complexes deacetylate histone (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
HDAC8 deacetylates histones (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Activation of Latent HCMV Genome (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
Delayed Early (DE) Gene Expression (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
Immediate Early (IE) Gene Expression (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
Transcriptional Activation of the HCMV Genome (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
HCMV Late Events (Homo sapiens)
Late (L) Gene Expression (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
AcK21-HIST1H2BJ [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06899 H2BC11
Gene Names
H2BC11, H2BFR, HIST1H2BJ
Chain
initiator methionine:, chain:2-126
Reference Genes
BioGPS Gene:8970 H2BC11
COSMIC (genes):HIST1H2BJ H2BC11
CTD Gene:8970 H2BC11
dbSNP Gene:8970 H2BC11
ENSEMBL:ENSG00000124635 HIST1H2BJ
HGNC:4761 H2BC11
KEGG:hsa:8970 H2BC11
Monarch:8970 H2BC11
NCBI Gene:8970 H2BC11
OMIM:615044 H2BC11
UCSC:P06899 H2BC11
Reference Transcript
RefSeq:NM_021058.3 H2BC11
Other Identifiers
11741699_at
11741700_s_at
11741701_x_at
153_f_at
17016451
2946696
2946697
2946698
2946699
2946700
2946709
2946710
2946711
2946712
3507751
8124484
85177_at
8970
A_24_P359231
A_24_P55148
GE557760
GE85150
GO:0000786
GO:0001530
GO:0002227
GO:0002376
GO:0003677
GO:0005198
GO:0005515
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0005886
GO:0006325
GO:0006334
GO:0008289
GO:0010804
GO:0019731
GO:0030527
GO:0031640
GO:0042742
GO:0043226
GO:0043229
GO:0043505
GO:0046982
GO:0050829
GO:0050830
GO:0061644
GO:0061844
GO:0065003
GO:0098542
HMNXSV003001392
ILMN_1658702
PH_hs_0035577
TC06001385.hg
TC06001386.hg
X00088_at
Participates
as a member of
AcK(6,13,16,21)-HIST1H2BJ [nucleoplasm] (Homo sapiens)
Other forms of this molecule
HIST1H2BJ [nucleoplasm]
Ub-121-HIST1H2BJ [nucleoplasm]
AcK13-HIST1H2BJ [nucleoplasm]
AcK16-HIST1H2BJ [nucleoplasm]
AcK6-HIST1H2BJ [nucleoplasm]
HIST1H2BJ [extracellular region]
AcK-HIST1H2BJ [nucleoplasm]
Ub-HIST1H2BJ [nucleoplasm]
Inferred To
AcK21-HIST1H2BJ [nucleoplasm]
(Bos taurus)
AcK21-HIST1H2BJ [nucleoplasm]
(Canis familiaris)
H2BC11 [nucleoplasm]
(Sus scrofa)
AcK21-HIST1H2BC [nucleoplasm]
(Danio rerio)
H2Bv2 [nucleoplasm]
(Dictyostelium discoideum)
htb1 [nucleoplasm]
(Schizosaccharomyces pombe)
HIST1H2B5L [nucleoplasm]
(Gallus gallus)
H2B-V [nucleoplasm]
(Gallus gallus)
H2Bv3 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VII [nucleoplasm]
(Gallus gallus)
H2B-I [nucleoplasm]
(Gallus gallus)
H2bc21 [nucleoplasm]
(Mus musculus)
Homologues of AcK21-HIST1H2BC [nucleoplasm]
(Danio rerio)
Homologues of AcK21-HIST1H2BC [nucleoplasm]
(Gallus gallus)
Homologues of AcK21-HIST1H2BC [nucleoplasm]
(Xenopus tropicalis)
HTB2 [nucleoplasm]
(Saccharomyces cerevisiae)
H2Bv1 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VIII [nucleoplasm]
(Gallus gallus)
His2B [nucleoplasm]
(Drosophila melanogaster)
h2bc11 [nucleoplasm]
(Xenopus tropicalis)
si:ch211-113a14.22 [nucleoplasm]
(Danio rerio)
LOC100498553 [nucleoplasm]
(Xenopus tropicalis)
LOC116411635 [nucleoplasm]
(Xenopus tropicalis)
AcK21-HIST1H2BB [nucleoplasm]
(Plasmodium falciparum)
Homologues of AcK21-HIST1H2BB [nucleoplasm]
(Dictyostelium discoideum)
Homologues of AcK21-HIST1H2BB [nucleoplasm]
(Plasmodium falciparum)
Homologues of AcK21-HIST1H2BB [nucleoplasm]
(Saccharomyces cerevisiae)
hist2h2l [nucleoplasm]
(Danio rerio)
HTB1 [nucleoplasm]
(Saccharomyces cerevisiae)
LOC570661 [nucleoplasm]
(Danio rerio)
h2bc21 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
N6-acetyl-L-lysine at 21
Coordinate
21
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
RefSeq
NP_066402.2
OpenTargets
ENSG00000124635
ENSEMBL
ENSP00000476136
,
ENSP00000342886
,
ENST00000339812
,
ENST00000607124
HPA
ENSG00000124635-H2BC11
PRO
P06899
Pharos - Targets
P06899
GlyGen
P06899
PDB
8KB5
,
8JH3
,
3AZL
,
7K63
,
8OSJ
,
6R91
,
5AV5
,
3W97
,
5X7X
,
6T90
,
7E8D
,
3AV1
,
5CPK
,
7XT7
,
8SMX
,
5B40
,
6JXD
,
6IPU
,
8SN5
,
8JLD
,
7XZX
,
6LA9
,
8OTS
,
6K1I
,
8JH2
,
5JRG
,
5XF5
,
6KVD
,
8JNF
,
3W96
,
5FUG
,
5CPI
,
7SCZ
,
6J4Y
,
6O1D
,
6IQ4
,
8HAN
,
7W9V
,
8GUK
,
5B0Y
,
6R92
,
8SN4
,
3AZE
,
8SN1
,
7D1Z
,
8UPF
,
6LA8
,
3WTP
,
7Y00
,
5B33
,
5Z23
,
3AZN
,
5Y0C
,
6K1K
,
7LYB
,
5AVC
,
3W99
,
5B24
,
3WA9
,
8JNE
,
6HKT
,
6R94
,
8YTI
,
6T93
,
6J50
,
7XSZ
,
8HAK
,
8GUI
,
6A5O
,
7XTI
,
8JLA
,
3AZG
,
6LER
,
8SMZ
,
8SN2
,
7YRD
,
8XBU
,
5GSE
,
8OTT
,
3AZM
,
7K5Y
,
8OSK
,
3W98
,
4CAY
,
7WBX
,
8I17
,
6J4W
,
8JND
,
5VEY
,
3AV2
,
6J4X
,
5GXQ
,
7XTD
,
6V2K
,
5CPJ
,
6A5L
,
8SN9
,
6M3V
,
3AZF
,
7D20
,
8SN6
,
6LA2
,
8JLB
,
8JL9
,
8XBT
,
7K5X
,
5B32
,
6INQ
,
6LAB
,
7LYA
,
5AV9
,
5AVB
,
8OSL
,
7WBW
,
8HAI
,
3AZI
,
8SN7
,
6A5R
,
5Z30
,
8HAG
,
6R8Z
,
6JR1
,
7XX6
,
4YM5
,
7C0M
,
8SN3
,
7K60
,
3AN2
,
3WAA
,
5B2J
,
5Y0D
,
7XVL
,
7COW
,
8HE5
,
7LYC
,
6K1J
,
7CCQ
,
5AV6
,
5AY8
,
7WBV
,
6JOU
,
6R93
,
6J4Z
,
6HTS
,
6A5P
,
8HAL
,
8H0V
,
8SMY
,
6E0P
,
6L4A
,
3AZH
,
6R8Y
,
7NL0
,
7XX5
,
6YOV
,
7XZY
,
8SN0
,
2RVQ
,
3A6N
,
8JH4
,
6L49
,
6USJ
,
7VCL
,
7VZ4
,
8RBX
,
5XF3
,
5GTC
,
6E0C
,
6J51
,
3AZK
,
7XSX
,
6A5T
,
8SN8
,
8HAM
,
8QKT
,
8HAH
,
8SNA
,
6M44
,
8GUJ
,
6IR9
,
6L9Z
,
7XZZ
,
8G57
,
5B31
,
7Y7I
,
5ZBX
,
8IHL
,
7CCR
,
5AV8
,
5XF4
,
7ZI4
,
7BY0
,
7SCY
,
6BUZ
,
8HAJ
,
6A5U
,
8SMW
,
3AZJ
,
8H0W
,
4Z5T
,
5B0Z
,
3AYW
,
4YM6
,
6JR0
,
6R90
,
8U14
,
7XSE
,
6KXV
,
7K61
,
3AFA
,
5B2I
,
7XVM
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
2
UniProt:P02675 FGB
5
FGB [extracellular region]
(R-HSA-140584)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
0.527
2
UniProt:P68871 HBB
8
HBB [lysosomal lumen]
(R-HSA-9625193)
HBB [cytosol]
(R-HSA-1008196)
HBB [late endosome lumen]
(R-HSA-9631108)
HBB [tertiary granule lumen]
(R-HSA-6800191)
HBB [extracellular region]
(R-HSA-2168872)
HBB [ficolin-1-rich granule lumen]
(R-HSA-6801015)
HBB [endocytic vesicle lumen]
(R-HSA-2230936)
CO-H+-HBB [cytosol]
(R-HSA-1237013)
0.527
2
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