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p-Y130,S141,T402-PAK2 [cytosol]
Stable Identifier
R-HSA-5218705
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
FYN phosphorylates PAK2 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
p-3Y-PAK2 dimer:CDC42:GTP [plasma membrane] (Homo sapiens)
p-3Y-PAK2 dimer [cytosol] (Homo sapiens)
p-Y130,S141,T402-PAK2 [cytosol] (Homo sapiens)
p38 MAPK activation by VEGFR (Homo sapiens)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
p-3Y-PAK2 dimer:CDC42:GTP [plasma membrane] (Homo sapiens)
p-3Y-PAK2 dimer [cytosol] (Homo sapiens)
p-Y130,S141,T402-PAK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13177 PAK2
Gene Names
PAK2
Chain
initiator methionine:, chain:2-524, chain:2-212, chain:213-524
Reference Genes
BioGPS Gene:5062 PAK2
COSMIC (genes):PAK2 PAK2
CTD Gene:5062 PAK2
dbSNP Gene:5062 PAK2
ENSEMBL:ENSG00000180370 PAK2
HGNC:8591 PAK2
KEGG:hsa:5062 PAK2
Monarch:5062 PAK2
NCBI Gene:5062 PAK2
OMIM:605022 PAK2
UCSC:Q13177 PAK2
Reference Transcript
RefSeq:NM_002577.4 PAK2
RefSeq:XM_017006501.1 PAK2
RefSeq:XM_011512870.2 PAK2
Other Identifiers
11739268_s_at
11739269_s_at
11739270_at
11739271_s_at
11739272_x_at
11739273_at
11739274_s_at
11739275_x_at
1245_i_at
1559052_PM_s_at
1559052_s_at
1560_g_at
16950017
208875_PM_s_at
208875_s_at
208876_PM_s_at
208876_s_at
208877_3p_at
208877_PM_at
208877_at
208878_PM_s_at
208878_s_at
2659578
2659584
2659585
2659586
2659587
2659588
2659589
2659590
2659591
2659593
2659594
2659597
2659600
2659601
2659602
2659603
2659604
2659605
2659606
2659607
2659608
2659609
2659610
2659611
2659612
2659613
2659614
2659630
34329_at
3612676
3612683
3612686
3612689
3612690
3612691
3612693
5062
55663_at
8084963
A_14_P125078
A_23_P327307
A_32_P104075
A_33_P3220833
GE59022
GO:0002223
GO:0002376
GO:0003012
GO:0003300
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006468
GO:0006469
GO:0006915
GO:0007165
GO:0012501
GO:0014069
GO:0016020
GO:0016310
GO:0016740
GO:0018105
GO:0019901
GO:0030141
GO:0030296
GO:0031267
GO:0031410
GO:0034330
GO:0034333
GO:0035556
GO:0042802
GO:0043066
GO:0043226
GO:0043408
GO:0045296
GO:0046777
GO:0048010
GO:0048471
GO:0048856
GO:0050731
GO:0050770
GO:0051493
GO:0051497
GO:0060996
GO:0070830
GO:0071407
GO:0071560
GO:0098772
GO:0098978
GO:0106310
GO:0140096
GO:0150105
GO:2001238
GO:2001271
HMNXSV003025856
Hs.284275.0.S1_3p_a_at
Hs.284275.0.S2_3p_a_at
Hs.284275.0.S4_3p_at
Hs.284275.0.S4_3p_s_at
Hs.284275.0.S4_3p_x_at
Hs.56974.0.A1_3p_s_at
Hs2.56974.1.S1_3p_s_at
ILMN_1676385
ILMN_1712687
PH_hs_0014731
TC03001100.hg
U25975_at
g5138913_3p_a_at
Participates
as a component of
p-3Y-PAK2 dimer [cytosol] (Homo sapiens)
Other forms of this molecule
p-S141,T402-PAK2 [cytosol]
PAK2 [cytosol]
p-5S-PAK2 [cytosol]
PAK2(213-524) [cytosol]
p-5S-PAK2(2-212) [cytosol]
p-T402-PAK2(213-524) [cytosol]
p-T402-PAK2(213-524) [nucleoplasm]
K48polyUb-p-T402-PAK-2p43 [cytosol]
PAK2(1-524) [plasma membrane]
p-S141,T402-PAK2 [plasma membrane]
Inferred To
phospho-p-Y130,S141,T402-PAK2 [cytosol]
(Bos taurus)
phospho-p-Y130,S141,T402-PAK2 [cytosol]
(Caenorhabditis elegans)
phospho-p-Y130,S141,T402-PAK2 [cytosol]
(Canis familiaris)
phospho-p-Y130,S141,T402-PAK2 [cytosol]
(Danio rerio)
phospho-p-Y130,S141,T402-PAK2 [cytosol]
(Drosophila melanogaster)
phospho-p-Y130,S141,T402-PAK2 [cytosol]
(Mus musculus)
phospho-p-Y130,S141,T402-PAK2 [cytosol]
(Rattus norvegicus)
phospho-p-Y130,S141,T402-PAK2 [cytosol]
(Sus scrofa)
phospho-PAK2 [cytosol]
(Gallus gallus)
Ghost homologue of p-Y130,S141,T402-PAK2 [cytosol]
(Xenopus tropicalis)
Homologues of p-Y130,S141,T402-PAK2 [cytosol]
(Caenorhabditis elegans)
Homologues of p-Y130,S141,T402-PAK2 [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-serine at 141
Coordinate
141
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 402
Coordinate
402
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 130
Coordinate
130
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_016861990.1
,
XP_011511172.1
,
NP_002568.2
ZINC - World Drugs
PAK2_HUMAN
Guide to Pharmacology - Targets
2134
OpenTargets
ENSG00000180370
ENSEMBL
ENSP00000314067
,
ENST00000327134
ZINC - FDA approved
PAK2_HUMAN
ZINC - Substances
PAK2_HUMAN
ZINC - Biogenic
PAK2_HUMAN
ZINC target
Q13177
PRO
Q13177
GlyGen
Q13177
PDB
3PCS
ZINC - Investigational
PAK2_HUMAN
HPA
ENSG00000180370-PAK2
Pharos - Targets
Q13177
ZINC - Predictions - Purchasable
PAK2_HUMAN
HMDB Protein
HMDBP01457
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.874
9
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.831
5
UniProt:Q15052 ARHGEF6
1
ARHGEF6 [cytosol]
(R-HSA-195017)
0.825
8
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.81
8
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.802
5
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.8
11
UniProt:Q9H4E5 RHOJ
1
RHOJ [plasma membrane]
(R-HSA-3006725)
0.782
7
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.775
6
UniProt:O60504 SORBS3
1
SORBS3 [cytosol]
(R-HSA-445805)
0.775
6
UniProt:Q9NVF7 FBX28
0.725
6
UniProt:Q14161 GIT2
1
GIT2 [cytosol]
(R-HSA-446034)
0.669
3
UniProt:O55043 Arhgef7
3
Arhgef7 [cytosol]
(R-RNO-430346)
p-S516-Arhgef7 [cytosol]
(R-RNO-9619782)
Arhgef7 [cytosol]
(R-RNO-442693)
0.655
8
UniProt:Q13153 PAK1
5
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
PAK1 [cytosol]
(R-HSA-162629)
Active PAK1 [cytosol]
(R-HSA-8964622)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [plasma membrane]
(R-HSA-3928409)
0.643
4
UniProt:P55210 CASP7
5
CASP7(24-198) [nucleoplasm]
(R-HSA-351927)
CASP7(207-303) [nucleoplasm]
(R-HSA-351924)
CASP7(2-303) [cytosol]
(R-HSA-57029)
CASP7(24-198) [cytosol]
(R-HSA-141641)
CASP7(207-303) [cytosol]
(R-HSA-141642)
0.619
6
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
0.602
3
UniProt:P53667 LIMK1
3
LIMK1 [cytosol]
(R-HSA-397785)
p-T508-LIMK1 [cytosol]
(R-HSA-399816)
p-S,T508-LIMK1 [cytosol]
(R-HSA-419610)
0.558
2
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.558
2
UniProt:Q5PP90 Q5PP90
0.558
2
UniProt:Q9NYB9-2 ABI2
0.556
3
UniProt:O60711 LPXN
0.527
2
UniProt:Q9NYY3 PLK2
1
PLK2 [cytosol]
(R-HSA-6801636)
0.527
2
UniProt:P02675 FGB
5
FGB [extracellular region]
(R-HSA-140584)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
0.527
2
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.527
2
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.527
2
UniProt:Q92845 KIFAP3
3
KIFAP3 [cytosol]
(R-HSA-984736)
KIFAP3 [cilium]
(R-HSA-5624882)
KIFAP3 [ciliary tip]
(R-HSA-5625382)
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:Q9BTV5 FSD1
0.527
2
UniProt:P05362 ICAM1
1
ICAM1 [plasma membrane]
(R-HSA-197683)
0.527
2
UniProt:O60404 OR10H3
1
OR10H3 [endoplasmic reticulum membrane]
(R-HSA-9751545)
0.527
2
UniProt:O94875 SRBS2
0.524
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.524
2
UniProt:P08631 HCK
2
p-HCK [cytosol]
(R-HSA-9676060)
HCK [cytosol]
(R-HSA-167708)
0.524
2
UniProt:Q8TEJ3 SH3R3
0.524
2
UniProt:P12931 SRC
6
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
0.524
2
UniProt:Q9BX66 SORBS1
1
SORBS1 [cytosol]
(R-HSA-445795)
0.524
2
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