Reactome | DIS3 [cytosol]

DIS3 [cytosol]

Stable Identifier

R-HSA-429935

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Exosome complex exonuclease RRP44, RRP44_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - PERK regulates gene expression (Homo sapiens)
      - ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
        
        Expression of IL-8 (Homo sapiens)
        
        KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
        
        Exosome Complex [cytosol] (Homo sapiens)
        
        DIS3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y2L1 DIS3

Gene Names

DIS3, KIAA1008, RRP44

Chain

chain:1-958

Reference Genes

BioGPS Gene:22894 DIS3

COSMIC (genes):DIS3 DIS3

CTD Gene:22894 DIS3

dbSNP Gene:22894 DIS3

ENSEMBL:ENSG00000083520 DIS3

ENSEMBL_homo_sapiens_GENE:ENSG00000083520.15 DIS3

HGNC:20604 DIS3

KEGG Gene (Homo sapiens):22894 DIS3

Monarch:22894 DIS3

NCBI Gene:22894 DIS3

OMIM:607533 DIS3

UCSC:Q9Y2L1 DIS3

Reference Transcript

Other Identifiers

11726622_a_at

11726623_a_at

11748232_a_at

16779725

214194_PM_at

214194_at

218362_3p_s_at

218362_PM_s_at

218362_s_at

222607_PM_s_at

222607_s_at

22894

234660_PM_s_at

234660_s_at

234757_PM_at

234757_at

236560_PM_at

236560_at

3517586

3517588

3517590

3517592

3517593

3517595

3517596

3517597

3517598

3517599

3517600

3517601

3517602

3517603

3517604

3517605

3517606

3517608

3517610

3517611

3517613

3517616

3517617

3517618

3517619

3517620

3517621

3517622

3517623

3517624

3517625

3517626

3517627

3517628

3517629

3517630

3517633

3517634

3517635

3517636

40633_at

7971965

7971967

84273_at

A_23_P412613

A_23_P48416

A_24_P219024

A_24_P395317

A_32_P205522

A_33_P3395502

GE53651

GO:0000175

GO:0000176

GO:0000177

GO:0000178

GO:0003723

GO:0003824

GO:0004518

GO:0004519

GO:0004527

GO:0004540

GO:0005085

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006364

GO:0006396

GO:0006401

GO:0016020

GO:0016071

GO:0016075

GO:0016787

GO:0042254

GO:0043226

GO:0043928

GO:0071034

GO:0098772

GO:0140098

HMNXSV003013894

HMNXSV003020865

Hs.179566.0.S1_3p_at

Hs.323346.0.S1_3p_a_at

Hs.323346.1.S1_3p_a_at

Hs.326725.0.A1_3p_at

Hs.59661.0.S1_3p_at

ILMN_1799796

PH_hs_0016095

TC13000727.hg

TC13001569.hg

U79246_at

g7662443_3p_x_at

Participates

as a component of

Exosome Complex [cytosol] (Homo sapiens)

Other forms of this molecule

DIS3 [nucleoplasm]

Inferred To

dis-3 [cytosol] (Caenorhabditis elegans)

DIS3 [cytosol] (Bos taurus)

DIS3 [cytosol] (Canis familiaris)

DIS3 [cytosol] (Dictyostelium discoideum)

DIS3 [cytosol] (Gallus gallus)

DIS3 [cytosol] (Saccharomyces cerevisiae)

DIS3 [cytosol] (Sus scrofa)

dis3 [cytosol] (Schizosaccharomyces pombe)

dis3 [cytosol] (Xenopus tropicalis)

Dis3 [cytosol] (Drosophila melanogaster)

Dis3 [cytosol] (Mus musculus)

Dis3 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001121698.1, NP_055768.3

OpenTargets

ENSG00000083520

HPA

ENSG00000083520-DIS3

GeneCards

Q9Y2L1

Ensembl

ENST00000377767, ENSP00000367011, ENST00000377780, ENSG00000083520, ENSP00000366997

PRO

Q9Y2L1

Pharos - Targets

Q9Y2L1

PDB

6H25, 6D6R, 6D6Q

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQT5 EXOSC3	2	EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [cytosol] (R-HSA-430017)	0.744	4
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.738	4
UniProt:Q13868 EXOSC2	2	EXOSC2 [nucleoplasm] (R-HSA-6791582) EXOSC2 [cytosol] (R-HSA-429999)	0.623	3
UniProt:Q96B26 EXOSC8	2	EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.547	2
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q96NY9 MUS81	1	MUS81 [nucleoplasm] (R-HSA-5686443)	0.527	3
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [extracellular region] (R-HSA-140584)	0.527	2
UniProt:P05120 SERPINB2	2	SERPINB2 [plasma membrane] (R-HSA-159004) SERPINB2 [extracellular region] (R-HSA-158997)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:Q9NPD3 EXOSC4	2	EXOSC4 [nucleoplasm] (R-HSA-6791503) EXOSC4 [cytosol] (R-HSA-430013)	0.462	2