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What is Reactome ?
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FGA(20-35) [extracellular region]
Stable Identifier
R-HSA-140867
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
fibrinopeptide A
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IRAK4 deficiency (TLR2/4) (Homo sapiens)
Defective IRAK4 does not bind MyD88 within the TLR2/4 complex (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 deficiency (TLR2/4) (Homo sapiens)
Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)
MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
IKKB phosphorylates SNAP23 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
Cleaved fibrinogen products bind TLR4:LY96 (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02671 FGA
Gene Names
FGA
Chain
signal peptide:1-19, peptide:20-35, chain:36-866
Reference Genes
BioGPS Gene:2243 FGA
COSMIC (genes):FGA FGA
CTD Gene:2243 FGA
dbSNP Gene:2243 FGA
ENSEMBL:ENSG00000171560 FGA
ENSEMBL_homo_sapiens_GENE:ENSG00000171560.18 FGA
HGNC:3661 FGA
KEGG Gene (Homo sapiens):2243 FGA
Monarch:2243 FGA
NCBI Gene:2243 FGA
OMIM:134820 FGA
UCSC:P02671 FGA
Reference Transcript
RefSeq:NM_021871.3 FGA
RefSeq:NM_000508.4 FGA
Other Identifiers
11731398_a_at
11731399_s_at
11749963_a_at
11757349_a_at
11757350_x_at
16980836
205649_PM_s_at
205649_s_at
205650_PM_s_at
205650_s_at
2243
2790625
2790627
2790628
2790629
2790630
2790631
2790632
2790633
2790634
2790635
2790636
2790637
2790638
2790639
2790640
2790641
2790642
2790643
2790644
2790645
2790646
2790647
2790648
2790649
38825_at
8103311
A_23_P375372
A_23_P44274
A_24_P282251
A_32_P42842
GE58040
GE79857
GO:0002250
GO:0002376
GO:0003013
GO:0005102
GO:0005198
GO:0005201
GO:0005515
GO:0005576
GO:0005577
GO:0005615
GO:0005783
GO:0005788
GO:0005886
GO:0007155
GO:0007160
GO:0007596
GO:0007599
GO:0009897
GO:0009986
GO:0012501
GO:0016192
GO:0023052
GO:0030168
GO:0030312
GO:0031012
GO:0031091
GO:0031093
GO:0031410
GO:0031639
GO:0034116
GO:0042060
GO:0042730
GO:0043152
GO:0043226
GO:0045087
GO:0045907
GO:0045921
GO:0046872
GO:0050714
GO:0050839
GO:0051258
GO:0051592
GO:0051604
GO:0062023
GO:0065003
GO:0070062
GO:0070374
GO:0070527
GO:0072377
GO:0072378
GO:0072562
GO:0090277
GO:0098542
GO:1900026
GO:1902042
GO:1903561
GO:2000352
HMNXSV003019079
ILMN_1656487
ILMN_1659947
ILMN_1779017
ILMN_2280203
ILMN_2381945
M58569_s_at
PH_hs_0028209
TC04001662.hg
TC04002793.hg
g11761627_3p_s_at
g11761628_3p_s_at
Participates
as an output of
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
as a member of
FGA, FGB, FGG [extracellular region] (Homo sapiens)
Other forms of this molecule
FGA(20-866) [platelet alpha granule lumen]
FGA(20-866) [extracellular region]
Variant fibrinogen alpha chain [extracellular region]
FGA [plasma membrane]
p-FGA [endoplasmic reticulum lumen]
FGA [endoplasmic reticulum lumen]
FGA [extracellular region]
Inferred To
FGA [extracellular region]
(Bos taurus)
FGA [extracellular region]
(Canis familiaris)
FGA [extracellular region]
(Sus scrofa)
FGA(20-35) [extracellular region]
(Gallus gallus)
FGA(20-35) [extracellular region]
(Mus musculus)
FGA(20-35) [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000499.1
,
NP_068657.1
OpenTargets
ENSG00000171560
GeneCards
P02671
HPA
ENSG00000171560-FGA
Ensembl
ENSG00000171560
,
ENSP00000498441
,
ENST00000403106
,
ENSP00000385981
,
ENST00000651975
PRO
P02671
Pharos - Targets
P02671
Orphanet
16040
HMDB Protein
HMDBP13512
PDB
1FZE
,
1N86
,
2HOD
,
2OYH
,
1FZD
,
1DM4
,
4F27
,
3AT0
,
1FZC
,
2OYI
,
3GHG
,
1BBR
,
1LTJ
,
1FPH
,
1FZB
,
1RE4
,
1FZA
,
2XNX
,
2HLO
,
1YCP
,
2HPC
,
1RE3
,
5CFA
,
2XNY
,
2H43
,
3BVH
,
1LT9
,
1RF1
,
1N8E
,
1FZG
,
2FFD
,
3H32
,
1FZF
,
2Q9I
,
2Z4E
,
1RF0
,
3E1I
,
3HUS
,
2A45
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02675 FGB
5
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [extracellular region]
(R-HSA-140584)
0.852
11
UniProt:P02679 FGG
5
FGG [platelet alpha granule lumen]
(R-HSA-140922)
FGG [plasma membrane]
(R-HSA-140918)
p-FGG [endoplasmic reticulum lumen]
(R-HSA-8956993)
FGG [endoplasmic reticulum lumen]
(R-HSA-8956692)
FGG [extracellular region]
(R-HSA-140585)
0.852
11
UniProt:Q8IXL6 FAM20C
1
FAM20C [endoplasmic reticulum lumen]
(R-HSA-8952276)
0.623
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.564
2
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.547
2
UniProt:Q99XV0 Q99XV0
0.524
2
UniProt:P02647 APOA1
11
APOA1(25-266) [secretory granule lumen]
(R-HSA-350761)
APOA1(25-267) [cytosol]
(R-HSA-2395781)
APOA1(25-267) [early endosome]
(R-HSA-2429641)
APOA1(25-267) [endoplasmic reticulum lumen]
(R-HSA-174640)
APOA1(19-266) [extracellular region]
(R-HSA-264771)
APOA1(25-266) [plasma membrane]
(R-HSA-216742)
Variant apolipoprotein AI [extracellular region]
(R-HSA-976865)
APOA1(25-266) [endocytic vesicle lumen]
(R-HSA-2239460)
APOA1(25-266) [extracellular region]
(R-HSA-174720)
p-APOA1 [endoplasmic reticulum lumen]
(R-HSA-8957081)
APOA1 [endoplasmic reticulum lumen]
(R-HSA-8956724)
0.483
2
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![FGA(20-35) [extracellular region] icon](/icon/R-ICO-012722.svg){kind=icon}
