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What is Reactome ?
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FGA(20-35) [extracellular region]
Stable Identifier
R-HSA-140867
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
fibrinopeptide A
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IRAK4 deficiency (TLR2/4) (Homo sapiens)
Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 deficiency (TLR2/4) (Homo sapiens)
Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)
MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
IKKB phosphorylates SNAP23 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
Cleaved fibrinogen products bind TLR4:LY96 (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:cleaved fibrinogen [plasma membrane] (Homo sapiens)
FGA, FGB, FGG [extracellular region] (Homo sapiens)
FGA(20-35) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02671 FGA
Gene Names
FGA
Chain
signal peptide:1-19, peptide:20-35, chain:36-866
Reference Genes
BioGPS Gene:2243 FGA
COSMIC (genes):FGA FGA
CTD Gene:2243 FGA
dbSNP Gene:2243 FGA
ENSEMBL:ENSG00000171560 FGA
HGNC:3661 FGA
KEGG:hsa:2243 FGA
Monarch:2243 FGA
NCBI Gene:2243 FGA
OMIM:134820 FGA
UCSC:P02671 FGA
Reference Transcript
RefSeq:NM_021871.3 FGA
RefSeq:NM_000508.4 FGA
Participates
as an output of
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)
as a member of
FGA, FGB, FGG [extracellular region] (Homo sapiens)
Other forms of this molecule
FGA [extracellular region]
FGA [plasma membrane]
FGA(20-866) [extracellular region]
FGA(20-866) [platelet alpha granule lumen]
FGA [endoplasmic reticulum lumen]
p-FGA [endoplasmic reticulum lumen]
Variant fibrinogen alpha chain [extracellular region]
Inferred To
FGA [extracellular region]
(Bos taurus)
FGA [extracellular region]
(Canis familiaris)
FGA [extracellular region]
(Sus scrofa)
FGA(20-35) [extracellular region]
(Gallus gallus)
FGA(20-35) [extracellular region]
(Mus musculus)
FGA(20-35) [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000499.1
,
NP_068657.1
OpenTargets
ENSG00000171560
ENSEMBL
ENST00000651975
,
ENSP00000385981
,
ENSG00000171560
,
ENSP00000498441
,
ENST00000403106
HPA
ENSG00000171560-FGA
GeneCards
FGA
PRO
P02671
Pharos - Targets
P02671
Orphanet
FGA
GlyGen
P02671
HMDB Protein
HMDBP13512
PDB
4F27
,
3GHG
,
2Z4E
,
3E1I
,
2XNX
,
2XNY
,
2A45
,
2H43
,
1RE4
,
2HOD
,
1FZD
,
2OYH
,
1RF0
,
2FFD
,
1RF1
,
2OYI
,
2HPC
,
1N8E
,
3HUS
,
2Q9I
,
1RE3
,
3H32
,
1N86
,
1FZA
,
1FZC
,
1FZB
,
2HLO
,
5CFA
,
1FPH
,
1YCP
,
1DM4
,
1BBR
,
3BVH
,
1LTJ
,
3AT0
,
1FZG
,
1FZE
,
1FZF
,
1LT9
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02679 FGG
5
FGG [extracellular region]
(R-HSA-140585)
FGG [plasma membrane]
(R-HSA-140918)
FGG [platelet alpha granule lumen]
(R-HSA-140922)
FGG [endoplasmic reticulum lumen]
(R-HSA-8956692)
p-FGG [endoplasmic reticulum lumen]
(R-HSA-8956993)
0.852
11
UniProt:P02675 FGB
5
FGB [extracellular region]
(R-HSA-140584)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
0.852
11
UniProt:Q8IXL6 FAM20C
1
FAM20C [endoplasmic reticulum lumen]
(R-HSA-8952276)
0.623
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.564
2
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.547
2
UniProt:Q99XV0 Q99XV0
0.524
2
UniProt:P02647 APOA1
11
APOA1(25-266) [extracellular region]
(R-HSA-174720)
APOA1 [endoplasmic reticulum lumen]
(R-HSA-8956724)
p-APOA1 [endoplasmic reticulum lumen]
(R-HSA-8957081)
APOA1(25-266) [endocytic vesicle lumen]
(R-HSA-2239460)
Variant apolipoprotein AI [extracellular region]
(R-HSA-976865)
APOA1(25-266) [plasma membrane]
(R-HSA-216742)
APOA1(19-266) [extracellular region]
(R-HSA-264771)
APOA1(25-267) [endoplasmic reticulum lumen]
(R-HSA-174640)
APOA1(25-267) [early endosome]
(R-HSA-2429641)
APOA1(25-267) [cytosol]
(R-HSA-2395781)
APOA1(25-266) [secretory granule lumen]
(R-HSA-350761)
0.483
2
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![FGA(20-35) [extracellular region] icon](/icon/R-ICO-012722.svg){kind=icon}
