Reactome | BioModels Database:BIOMD0000000656

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BioModels Database:BIOMD0000000656 Show undefined attributes

created	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
databaseName	BioModels Database
dbId	12819435
displayName	BioModels Database:BIOMD0000000656
identifier	BIOMD0000000656
referenceDatabase	[ReferenceDatabase:12819428] BioModels Database
schemaClass	DatabaseIdentifier
url	https://www.ebi.ac.uk/biomodels/BIOMD0000000656

Referrals

(crossReference)

[Pathway:R-HSA-9027284] Erythropoietin activates RAS
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
[Pathway:R-HSA-354194] GRB2:SOS provides linkage to MAPK signaling for Integrins
[Pathway:R-HSA-389513] Co-inhibition by CTLA4
[Pathway:R-HSA-9726840] SHOC2 M1731 mutant abolishes MRAS complex function
[Pathway:R-HSA-2871796] FCERI mediated MAPK activation
[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants
[Pathway:R-HSA-9732724] IFNG signaling activates MAPKs
[Pathway:R-HSA-5467337] APC truncation mutants have impaired AXIN binding
[Pathway:R-HSA-8847993] ERBB2 Activates PTK6 Signaling
[Pathway:R-HSA-5358751] CTNNB1 S45 mutants aren't phosphorylated
[Pathway:R-HSA-1251932] PLCG1 events in ERBB2 signaling
[Pathway:R-HSA-354192] Integrin signaling
[Pathway:R-HSA-5467333] APC truncation mutants are not K63 polyubiquitinated
[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway
[Pathway:R-HSA-198753] ERK/MAPK targets
[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants
[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway
[Pathway:R-HSA-196299] Beta-catenin phosphorylation cascade
[Pathway:R-HSA-199418] Negative regulation of the PI3K/AKT network
[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII
[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants
[Pathway:R-HSA-5358747] CTNNB1 S33 mutants aren't phosphorylated
[Pathway:R-HSA-179812] GRB2 events in EGFR signaling
[Pathway:R-HSA-5467340] AXIN missense mutants destabilize the destruction complex
[Pathway:R-HSA-5467348] Truncations of AMER1 destabilize the destruction complex
[Pathway:R-HSA-9726842] Gain-of-function MRAS complexes activate RAF signaling
[Pathway:R-HSA-9656223] Signaling by RAF1 mutants
[Pathway:R-HSA-170968] Frs2-mediated activation
[Pathway:R-HSA-5673000] RAF activation
[Pathway:R-HSA-110056] MAPK3 (ERK1) activation
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants
[Pathway:R-HSA-442742] CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
[Pathway:R-HSA-177929] Signaling by EGFR
[Pathway:R-HSA-6802952] Signaling by BRAF and RAF1 fusions
[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer
[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma
[Pathway:R-HSA-9754189] Germ layer formation at gastrulation
[Pathway:R-HSA-198323] AKT phosphorylates targets in the cytosol
[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT
[Pathway:R-HSA-112409] RAF-independent MAPK1/3 activation
[Pathway:R-HSA-5674135] MAP2K and MAPK activation
[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants
[Pathway:R-HSA-5358749] CTNNB1 S37 mutants aren't phosphorylated
[Pathway:R-HSA-444257] RSK activation
[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants
[Pathway:R-HSA-5358752] CTNNB1 T41 mutants aren't phosphorylated
[Pathway:R-HSA-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
[Pathway:R-HSA-5654727] Negative regulation of FGFR2 signaling
[Pathway:R-HSA-1295596] Spry regulation of FGF signaling
[CellLineagePath:R-HSA-9927432] Developmental Lineage of Mammary Gland Myoepithelial Cells
[Pathway:R-HSA-1963640] GRB2 events in ERBB2 signaling
[Pathway:R-HSA-5654733] Negative regulation of FGFR4 signaling
[Pathway:R-HSA-1250196] SHC1 events in ERBB2 signaling
[Pathway:R-HSA-180336] SHC1 events in EGFR signaling
[Pathway:R-HSA-180292] GAB1 signalosome
[Pathway:R-HSA-76009] Platelet Aggregation (Plug Formation)
[Pathway:R-HSA-202670] ERKs are inactivated
[Pathway:R-HSA-5638303] Inhibition of Signaling by Overexpressed EGFR
[Pathway:R-HSA-182971] EGFR downregulation
[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
[Pathway:R-HSA-2424491] DAP12 signaling
[Pathway:R-HSA-9652169] Signaling by MAP2K mutants
[Pathway:R-HSA-5654732] Negative regulation of FGFR3 signaling
[Pathway:R-HSA-8951430] RUNX3 regulates WNT signaling
[Pathway:R-HSA-5339716] Signaling by GSK3beta mutants
[Pathway:R-HSA-195253] Degradation of beta-catenin by the destruction complex
[Pathway:R-HSA-5674404] PTEN Loss of Function in Cancer
[Pathway:R-HSA-6785631] ERBB2 Regulates Cell Motility
[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF
[Pathway:R-HSA-4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters
[Pathway:R-HSA-5654726] Negative regulation of FGFR1 signaling
[Pathway:R-HSA-8851805] MET activates RAS signaling
[Pathway:R-HSA-112412] SOS-mediated signalling
[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane

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