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Schema
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Pathway
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Entries
Signaling by ERBB2 ECD mutants
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authored
[InstanceEdit:9665241] Orlic-Milacic, Marija, 2019-10-30
created
[InstanceEdit:9665340] Orlic-Milacic, Marija, 2019-10-30
crossReference
[DatabaseIdentifier:12325424] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12325370] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12325372] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12325526] BioModels Database:BIOMD0000000594
[DatabaseIdentifier:12325374] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12325476] BioModels Database:BIOMD0000000466
[DatabaseIdentifier:12325528] BioModels Database:BIOMD0000000223
[DatabaseIdentifier:12325430] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12325378] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12325530] BioModels Database:BIOMD0000000595
[DatabaseIdentifier:12325380] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12325480] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12325442] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12325444] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477
[DatabaseIdentifier:12325446] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12325382] BioModels Database:BIOMD0000000654
dbId
9665348
disease
[Disease:1500689] cancer
displayName
Signaling by ERBB2 ECD mutants
doi
10.3180/R-HSA-9665348.1
edited
[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
eventOf
[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-9665388] ERBB2 ECD mutants heterodimerize with EGFR - Homo sapiens
[Reaction:R-HSA-9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate - Homo sapiens
[Reaction:R-HSA-9665416] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 - Homo sapiens
[Reaction:R-HSA-9665406] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 - Homo sapiens
[Reaction:R-HSA-9665413] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1 - Homo sapiens
[Reaction:R-HSA-9665404] RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 - Homo sapiens
[Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR - Homo sapiens
[Reaction:R-HSA-9665408] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 - Homo sapiens
[Reaction:R-HSA-9665417] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 - Homo sapiens
[Reaction:R-HSA-9665415] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K - Homo sapiens
[Reaction:R-HSA-9665407] PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-9665410] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 - Homo sapiens
[Reaction:R-HSA-9665411] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 - Homo sapiens
[Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab - Homo sapiens
[Reaction:R-HSA-9665412] ERBB2 ECD mutants bind TKIs - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9665365] Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
Signaling by ERBB2 ECD mutants
normalPathway
[Pathway:R-HSA-1227986] Signaling by ERBB2
releaseDate
2020-03-17
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9666036] Bose, Ron, 2019-10-25
[InstanceEdit:9666034] Krishna, Anagha, 2019-10-25
[InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9665348
summation
[Summation:9665375] ERBB2 extracellular domain (ECD) mutants harbor missense mut...
Referrals
(hasEvent)
[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer
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