Reactome | Signaling by ERBB2 ECD mutants

Schema > Pathway > Entries

Signaling by ERBB2 ECD mutants Show undefined attributes

authored	[InstanceEdit:9665241] Orlic-Milacic, Marija, 2019-10-30
created	[InstanceEdit:9665340] Orlic-Milacic, Marija, 2019-10-30
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819561] BioModels Database:BIOMD0000000594 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819563] BioModels Database:BIOMD0000000223 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819565] BioModels Database:BIOMD0000000595 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	9665348
disease	[Disease:1500689] cancer
displayName	Signaling by ERBB2 ECD mutants
doi	10.3180/R-HSA-9665348.1
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
eventOf	[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9665388] ERBB2 ECD mutants heterodimerize with EGFR - Homo sapiens [Reaction:R-HSA-9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate - Homo sapiens [Reaction:R-HSA-9665416] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 - Homo sapiens [Reaction:R-HSA-9665406] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 - Homo sapiens [Reaction:R-HSA-9665413] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1 - Homo sapiens [Reaction:R-HSA-9665404] RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR - Homo sapiens [Reaction:R-HSA-9665408] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 - Homo sapiens [Reaction:R-HSA-9665417] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 - Homo sapiens [Reaction:R-HSA-9665415] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K - Homo sapiens [Reaction:R-HSA-9665407] PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-9665410] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 - Homo sapiens [Reaction:R-HSA-9665411] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 - Homo sapiens [Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab - Homo sapiens [Reaction:R-HSA-9665412] ERBB2 ECD mutants bind TKIs - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9665365] Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2 [LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Signaling by ERBB2 ECD mutants
normalPathway	[Pathway:R-HSA-1227986] Signaling by ERBB2
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9666036] Bose, Ron, 2019-10-25 [InstanceEdit:9666034] Krishna, Anagha, 2019-10-25 [InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9665348
summation	[Summation:9665375] ERBB2 extracellular domain (ECD) mutants harbor missense mut...

Referrals

(hasEvent)

[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer

Cite Us!