Reactome | Degradation of beta-catenin by the destruction complex

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Degradation of beta-catenin by the destruction complex Show undefined attributes

authored	[InstanceEdit:195289] Kimelman, D, 2007-04-03 12:34:14
created	[InstanceEdit:195254] Matthews, L, 2007-04-03 04:37:36
crossReference	[DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819475] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	195253
diseasePathways	[Pathway:R-HSA-5339716] Signaling by GSK3beta mutants - Homo sapiens [Pathway:R-HSA-5339700] Signaling by TCF7L2 mutants - Homo sapiens [Pathway:R-HSA-5358752] CTNNB1 T41 mutants aren't phosphorylated - Homo sapiens [Pathway:R-HSA-5358747] CTNNB1 S33 mutants aren't phosphorylated - Homo sapiens [Pathway:R-HSA-5358749] CTNNB1 S37 mutants aren't phosphorylated - Homo sapiens [Pathway:R-HSA-5358751] CTNNB1 S45 mutants aren't phosphorylated - Homo sapiens [Pathway:R-HSA-5467333] APC truncation mutants are not K63 polyubiquitinated - Homo sapiens [Pathway:R-HSA-5467337] APC truncation mutants have impaired AXIN binding - Homo sapiens [Pathway:R-HSA-5467348] Truncations of AMER1 destabilize the destruction complex - Homo sapiens [Pathway:R-HSA-5467343] Deletions in the AMER1 gene destabilize the destruction complex - Homo sapiens [Pathway:R-HSA-5467345] Deletions in the AXIN1 gene destabilize the destruction complex - Homo sapiens [Pathway:R-HSA-5467340] AXIN missense mutants destabilize the destruction complex - Homo sapiens
displayName	Degradation of beta-catenin by the destruction complex
doi	10.3180/REACT_11063.1
edited	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
eventOf	[Pathway:R-HSA-195721] Signaling by WNT - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-5251557] Expression of AMER1 gene - Homo sapiens [BlackBoxEvent:R-HSA-5251555] Expression of AXIN1 gene - Homo sapiens [Reaction:R-HSA-5246693] APC is K63-polyubiquitinated - Homo sapiens [Reaction:R-HSA-6781905] ZRANB1 binds APC - Homo sapiens [Reaction:R-HSA-195251] Assembly of the destruction complex - Homo sapiens [Reaction:R-HSA-5229343] AXIN is phosphorylated in the destruction complex - Homo sapiens [Reaction:R-HSA-195304] Association of beta-catenin with the destruction complex - Homo sapiens [Pathway:R-HSA-196299] Beta-catenin phosphorylation cascade - Homo sapiens [Reaction:R-HSA-195275] Phosphorylation of APC component of the destruction complex - Homo sapiens [Reaction:R-HSA-195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex - Homo sapiens [Reaction:R-HSA-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex - Homo sapiens [Reaction:R-HSA-2130286] Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) - Homo sapiens [BlackBoxEvent:R-HSA-2130282] Degradation of ubiquitinated beta catenin by the proteasome - Homo sapiens [Pathway:R-HSA-4641265] Repression of WNT target genes - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-12-10
literatureReference	[LiteratureReference:195314] beta-catenin destruction complex: insights and questions from a structural perspective
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Degradation of beta-catenin by the destruction complex
orthologousEvent	[Pathway:R-MMU-195253] Degradation of beta-catenin by the destruction complex - Mus musculus [Pathway:R-RNO-195253] Degradation of beta-catenin by the destruction complex - Rattus norvegicus [Pathway:R-CFA-195253] Degradation of beta-catenin by the destruction complex - Canis familiaris [Pathway:R-BTA-195253] Degradation of beta-catenin by the destruction complex - Bos taurus [Pathway:R-SSC-195253] Degradation of beta-catenin by the destruction complex - Sus scrofa [Pathway:R-DRE-195253] Degradation of beta-catenin by the destruction complex - Danio rerio [Pathway:R-XTR-195253] Degradation of beta-catenin by the destruction complex - Xenopus tropicalis [Pathway:R-GGA-195253] Degradation of beta-catenin by the destruction complex - Gallus gallus [Pathway:R-DME-195253] Degradation of beta-catenin by the destruction complex - Drosophila melanogaster [Pathway:R-CEL-195253] Degradation of beta-catenin by the destruction complex - Caenorhabditis elegans
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196987] Pagano, M, 2007-04-27 13:02:18
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-195253
summation	[Summation:195310] The beta-catenin destruction complex plays a key role in the...
updateTrackers	[UpdateTracker:9782109] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v59:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788885] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v40:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9787871] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v44:[updateContainedRLE] [UpdateTracker:9777419] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v71:[addHasEvent] [UpdateTracker:9786897] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v47:[updateContainedRLE] [UpdateTracker:9786734] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v48:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9786091] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v50:[updateIndirectRLE] [UpdateTracker:9789560] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v37:[updateIndirectRLE] [UpdateTracker:9792229] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v22:[updateContainedRLE] [UpdateTracker:9787303] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v45:[updateContainedRLE] [UpdateTracker:9789440] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v38:[updateContainedRLE] [UpdateTracker:9786580] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v49:[addHasEvent, updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-195721] Signaling by WNT
(hasEncapsulatedEvent)	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT [Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1
(normalPathway)	[Pathway:R-HSA-5339716] Signaling by GSK3beta mutants [Pathway:R-HSA-5339700] Signaling by TCF7L2 mutants [Pathway:R-HSA-5358752] CTNNB1 T41 mutants aren't phosphorylated [Pathway:R-HSA-5358747] CTNNB1 S33 mutants aren't phosphorylated [Pathway:R-HSA-5358749] CTNNB1 S37 mutants aren't phosphorylated [Pathway:R-HSA-5358751] CTNNB1 S45 mutants aren't phosphorylated [Pathway:R-HSA-5467333] APC truncation mutants are not K63 polyubiquitinated [Pathway:R-HSA-5467337] APC truncation mutants have impaired AXIN binding [Pathway:R-HSA-5467348] Truncations of AMER1 destabilize the destruction complex [Pathway:R-HSA-5467343] Deletions in the AMER1 gene destabilize the destruction complex [Pathway:R-HSA-5467345] Deletions in the AXIN1 gene destabilize the destruction complex [Pathway:R-HSA-5467340] AXIN missense mutants destabilize the destruction complex
(updatedInstance)	[UpdateTracker:9782109] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v59:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788885] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v40:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9787871] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v44:[updateContainedRLE] [UpdateTracker:9777419] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v71:[addHasEvent] [UpdateTracker:9786897] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v47:[updateContainedRLE] [UpdateTracker:9786734] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v48:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9786091] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v50:[updateIndirectRLE] [UpdateTracker:9789560] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v37:[updateIndirectRLE] [UpdateTracker:9792229] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v22:[updateContainedRLE] [UpdateTracker:9787303] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v45:[updateContainedRLE] [UpdateTracker:9789440] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v38:[updateContainedRLE] [UpdateTracker:9786580] Update Tracker - [Pathway:195253] Degradation of beta-catenin by the destruction complex - v49:[addHasEvent, updateContainedRLE]

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