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Entries
Constitutive Signaling by AKT1 E17K in Cancer
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authored
[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
created
[InstanceEdit:5674406] Orlic-Milacic, Marija, 2015-02-12
crossReference
[DatabaseIdentifier:12020745] Mondo:0004992
[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12819467] BioModels Database:BIOMD0000000581
[DatabaseIdentifier:12819599] BioModels Database:BIOMD0000000582
[DatabaseIdentifier:12819643] BioModels Database:BIOMD0000000465
[DatabaseIdentifier:12819477] BioModels Database:BIOMD0000000651
[DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12819581] BioModels Database:BIOMD0000000943
[DatabaseIdentifier:12819651] BioModels Database:BIOMD0000000356
[DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId
5674400
disease
[Disease:1500689] cancer
displayName
Constitutive Signaling by AKT1 E17K in Cancer
eventOf
[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-2219536] AKT1 E17K mutant binds PIP2 - Homo sapiens
[Reaction:R-HSA-2243938] AKT1 E17K mutant is phosphorylated by TORC2 complex - Homo sapiens
[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 - Homo sapiens
[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant - Homo sapiens
[Reaction:R-HSA-2399966] AKT1 E17K mutant phosphorylates GSK3 - Homo sapiens
[Reaction:R-HSA-2399969] AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 - Homo sapiens
[Reaction:R-HSA-2399941] AKT1 E17K mutant phosphorylates BAD - Homo sapiens
[Reaction:R-HSA-2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) - Homo sapiens
[Reaction:R-HSA-2399981] AKT1 E17K mutant phosphorylates MDM2 - Homo sapiens
[Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - Homo sapiens
[Reaction:R-HSA-2400001] AKT1 E17K mutant phosphorylates CHUK (IKKalpha) - Homo sapiens
[Reaction:R-HSA-2399985] AKT1 E17K mutant phosphorylates caspase-9 - Homo sapiens
[Reaction:R-HSA-2399997] AKT1 E17K mutant translocates to the nucleus - Homo sapiens
[Reaction:R-HSA-2399992] AKT1 E17K mutant phosphorylates forkhead box transcription factors - Homo sapiens
[Reaction:R-HSA-2399996] AKT1 E17K mutant phosphorylates CREB1 - Homo sapiens
[Reaction:R-HSA-2399999] AKT1 E17K mutant phosphorylates RSK - Homo sapiens
[Reaction:R-HSA-2399988] AKT1 E17K mutant phosphorylates NR4A1 (NUR77) - Homo sapiens
[Reaction:R-HSA-2400010] AKT inhibitors block AKT membrane recruitment - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2022-04-07
literatureReference
[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
[LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain
maxDepth
2
modified
[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name
Constitutive Signaling by AKT1 E17K in Cancer
normalPathway
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
releaseDate
2012-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13
[InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5674400
summation
[Summation:5674403] While AKT1 gene copy number, expression level and phosphoryl...
updateTrackers
[UpdateTracker:9774909] Update Tracker - [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer - v80:[updateContainedRLE]
[UpdateTracker:9779293] Update Tracker - [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer - v66:[updateContainedRLE]
[UpdateTracker:9782999] Update Tracker - [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer - v58:[updateContainedRLE]
[UpdateTracker:9784287] Update Tracker - [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer - v54:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer
(updatedInstance)
[UpdateTracker:9774909] Update Tracker - [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer - v80:[updateContainedRLE]
[UpdateTracker:9779293] Update Tracker - [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer - v66:[updateContainedRLE]
[UpdateTracker:9782999] Update Tracker - [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer - v58:[updateContainedRLE]
[UpdateTracker:9784287] Update Tracker - [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer - v54:[updateContainedRLE]
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