Reactome | Constitutive Signaling by AKT1 E17K in Cancer

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Constitutive Signaling by AKT1 E17K in Cancer Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
created	[InstanceEdit:5674406] Orlic-Milacic, Marija, 2015-02-12
crossReference	[DatabaseIdentifier:12325424] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12325370] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12325372] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12325426] BioModels Database:BIOMD0000000581 [DatabaseIdentifier:12325582] BioModels Database:BIOMD0000000582 [DatabaseIdentifier:12325600] BioModels Database:BIOMD0000000465 [DatabaseIdentifier:12325438] BioModels Database:BIOMD0000000651 [DatabaseIdentifier:12325374] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12325562] BioModels Database:BIOMD0000000943 [DatabaseIdentifier:12325644] BioModels Database:BIOMD0000000356 [DatabaseIdentifier:12325378] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12325380] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12325480] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12325382] BioModels Database:BIOMD0000000654
dbId	5674400
disease	[Disease:1500689] cancer
displayName	Constitutive Signaling by AKT1 E17K in Cancer
eventOf	[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-2219536] AKT1 E17K mutant binds PIP2 - Homo sapiens [Reaction:R-HSA-2243938] AKT1 E17K mutant is phosphorylated by TORC2 complex - Homo sapiens [Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 - Homo sapiens [Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant - Homo sapiens [Reaction:R-HSA-2399966] AKT1 E17K mutant phosphorylates GSK3 - Homo sapiens [Reaction:R-HSA-2399969] AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 - Homo sapiens [Reaction:R-HSA-2399941] AKT1 E17K mutant phosphorylates BAD - Homo sapiens [Reaction:R-HSA-2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) - Homo sapiens [Reaction:R-HSA-2399981] AKT1 E17K mutant phosphorylates MDM2 - Homo sapiens [Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - Homo sapiens [Reaction:R-HSA-2400001] AKT1 E17K mutant phosphorylates CHUK (IKKalpha) - Homo sapiens [Reaction:R-HSA-2399985] AKT1 E17K mutant phosphorylates caspase-9 - Homo sapiens [Reaction:R-HSA-2399997] AKT1 E17K mutant translocates to the nucleus - Homo sapiens [Reaction:R-HSA-2399992] AKT1 E17K mutant phosphorylates forkhead box transcription factors - Homo sapiens [Reaction:R-HSA-2399996] AKT1 E17K mutant phosphorylates CREB1 - Homo sapiens [Reaction:R-HSA-2399999] AKT1 E17K mutant phosphorylates RSK - Homo sapiens [Reaction:R-HSA-2399988] AKT1 E17K mutant phosphorylates NR4A1 (NUR77) - Homo sapiens [Reaction:R-HSA-2400010] AKT inhibitors block AKT membrane recruitment - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Constitutive Signaling by AKT1 E17K in Cancer
normalPathway	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5674400
summation	[Summation:5674403] While AKT1 gene copy number, expression level and phosphoryl...

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(hasEvent)

[Pathway:R-HSA-2219528] PI3K/AKT Signaling in Cancer

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