Reactome | RAF activation

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RAF activation Show undefined attributes

authored	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
created	[InstanceEdit:5672999] Rothfels, Karen, 2015-02-06
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819473] BioModels Database:BIOMD0000000659 [DatabaseIdentifier:12819475] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12819429] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12819477] BioModels Database:BIOMD0000000651 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819479] BioModels Database:BIOMD0000000288 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	5673000
deleted	[Deleted:6798804] Deletion of instance: 110029
displayName	RAF activation
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5672951] Inactive RAFs bind YWHAB - Homo sapiens [Reaction:R-HSA-5672961] PP2A dephosphorylates inactive RAFs - Homo sapiens [Reaction:R-HSA-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Homo sapiens [Reaction:R-HSA-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Homo sapiens [Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP - Homo sapiens [Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Homo sapiens [Reaction:R-HSA-5672948] MARK3 phosphorylates KSR1 - Homo sapiens [Reaction:R-HSA-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Homo sapiens [Reaction:R-HSA-5672957] PP2A dephosphorylates KSR1 - Homo sapiens [Reaction:R-HSA-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Homo sapiens [Reaction:R-HSA-5672969] Phosphorylation of RAF - Homo sapiens [Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-06-07
literatureReference	[LiteratureReference:5672286] Structure and biological activity of human homologs of the raf/mil oncogene [LiteratureReference:5672187] Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene [LiteratureReference:5672205] MEK kinase activity is not necessary for Raf-1 function [LiteratureReference:5672176] ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf [LiteratureReference:5672257] Raf kinases: function, regulation and role in human cancer [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5672144] "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway [LiteratureReference:5672236] Mutations of the BRAF gene in human cancer [LiteratureReference:5672190] Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases [LiteratureReference:5672261] Raf-1 without MEK? [LiteratureReference:5672173] B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms [LiteratureReference:5672275] Regulation of Raf-1 activation and signalling by dephosphorylation [LiteratureReference:5672243] Positive and negative regulation of Raf kinase activity and function by phosphorylation [LiteratureReference:5672163] Autoregulation of the Raf-1 serine/threonine kinase [LiteratureReference:5672273] Regulation of Raf through phosphorylation and N terminus-C terminus interaction [LiteratureReference:5672158] Allosteric activation of functionally asymmetric RAF kinase dimers [LiteratureReference:5672195] Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF [LiteratureReference:5672291] Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	RAF activation
orthologousEvent	[Pathway:R-MMU-5673000] RAF activation - Mus musculus [Pathway:R-RNO-5673000] RAF activation - Rattus norvegicus [Pathway:R-CFA-5673000] RAF activation - Canis familiaris [Pathway:R-BTA-5673000] RAF activation - Bos taurus [Pathway:R-SSC-5673000] RAF activation - Sus scrofa [Pathway:R-DRE-5673000] RAF activation - Danio rerio [Pathway:R-XTR-5673000] RAF activation - Xenopus tropicalis [Pathway:R-GGA-5673000] RAF activation - Gallus gallus [Pathway:R-DME-5673000] RAF activation - Drosophila melanogaster [Pathway:R-CEL-5673000] RAF activation - Caenorhabditis elegans [Pathway:R-DDI-5673000] RAF activation - Dictyostelium discoideum [Pathway:R-PFA-5673000] RAF activation - Plasmodium falciparum
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5673000
summation	[Summation:5672619] Mammals have three RAF isoforms, A, B and C, that are activa...
updateTrackers	[UpdateTracker:9778713] Update Tracker - [Pathway:5673000] RAF activation - v67:[updateContainedRLE] [UpdateTracker:9835706] Update Tracker - [Pathway:5673000] RAF activation - v85:[updateContainedRLE] [UpdateTracker:9776982] Update Tracker - [Pathway:5673000] RAF activation - v73:[addHasEvent] [UpdateTracker:9783823] Update Tracker - [Pathway:5673000] RAF activation - v55:[updateContainedRLE] [UpdateTracker:9782922] Update Tracker - [Pathway:5673000] RAF activation - v58:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
(replacementInstances)	[Deleted:6798804] Deletion of instance: 110029
(updatedInstance)	[UpdateTracker:9778713] Update Tracker - [Pathway:5673000] RAF activation - v67:[updateContainedRLE] [UpdateTracker:9835706] Update Tracker - [Pathway:5673000] RAF activation - v85:[updateContainedRLE] [UpdateTracker:9776982] Update Tracker - [Pathway:5673000] RAF activation - v73:[addHasEvent] [UpdateTracker:9783823] Update Tracker - [Pathway:5673000] RAF activation - v55:[updateContainedRLE] [UpdateTracker:9782922] Update Tracker - [Pathway:5673000] RAF activation - v58:[updateContainedRLE]

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