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Entries
RAF activation
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authored
[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
created
[InstanceEdit:5672999] Rothfels, Karen, 2015-02-06
crossReference
[DatabaseIdentifier:12325424] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12325370] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12325372] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12325434] BioModels Database:BIOMD0000000659
[DatabaseIdentifier:12325436] BioModels Database:BIOMD0000000149
[DatabaseIdentifier:12325344] BioModels Database:BIOMD0000000664
[DatabaseIdentifier:12325438] BioModels Database:BIOMD0000000651
[DatabaseIdentifier:12325374] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12325378] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12325440] BioModels Database:BIOMD0000000288
[DatabaseIdentifier:12325380] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12325442] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12325444] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12325446] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12325382] BioModels Database:BIOMD0000000654
dbId
5673000
displayName
RAF activation
edited
[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5672951] Inactive RAFs bind YWHAB - Homo sapiens
[Reaction:R-HSA-5672961] PP2A dephosphorylates inactive RAFs - Homo sapiens
[Reaction:R-HSA-9658445] MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs - Homo sapiens
[Reaction:R-HSA-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Homo sapiens
[Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP - Homo sapiens
[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Homo sapiens
[Reaction:R-HSA-5672948] MARK3 phosphorylates KSR1 - Homo sapiens
[Reaction:R-HSA-5672954] p-S311,S406 KSR1:MARK3 binds YWHAB dimer - Homo sapiens
[Reaction:R-HSA-5672957] PP2A dephosphorylates KSR1 - Homo sapiens
[Reaction:R-HSA-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Homo sapiens
[Reaction:R-HSA-5672969] Phosphorylation of RAF - Homo sapiens
[Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5672286] Structure and biological activity of human homologs of the raf/mil oncogene
[LiteratureReference:5672187] Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
[LiteratureReference:5672205] MEK kinase activity is not necessary for Raf-1 function
[LiteratureReference:5672176] ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf
[LiteratureReference:5672257] Raf kinases: function, regulation and role in human cancer
[LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks
[LiteratureReference:5672144] "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway
[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer
[LiteratureReference:5672190] Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases
[LiteratureReference:5672261] Raf-1 without MEK?
[LiteratureReference:5672173] B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms
[LiteratureReference:5672275] Regulation of Raf-1 activation and signalling by dephosphorylation
[LiteratureReference:5672243] Positive and negative regulation of Raf kinase activity and function by phosphorylation
[LiteratureReference:5672163] Autoregulation of the Raf-1 serine/threonine kinase
[LiteratureReference:5672273] Regulation of Raf through phosphorylation and N terminus-C terminus interaction
[LiteratureReference:5672158] Allosteric activation of functionally asymmetric RAF kinase dimers
[LiteratureReference:5672195] Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
[LiteratureReference:5672291] Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
RAF activation
orthologousEvent
[Pathway:R-MMU-5673000] RAF activation - Mus musculus
[Pathway:R-RNO-5673000] RAF activation - Rattus norvegicus
[Pathway:R-CFA-5673000] RAF activation - Canis familiaris
[Pathway:R-BTA-5673000] RAF activation - Bos taurus
[Pathway:R-SSC-5673000] RAF activation - Sus scrofa
[Pathway:R-DRE-5673000] RAF activation - Danio rerio
[Pathway:R-XTR-5673000] RAF activation - Xenopus tropicalis
[Pathway:R-GGA-5673000] RAF activation - Gallus gallus
[Pathway:R-DME-5673000] RAF activation - Drosophila melanogaster
[Pathway:R-CEL-5673000] RAF activation - Caenorhabditis elegans
[Pathway:R-DDI-5673000] RAF activation - Dictyostelium discoideum
[Pathway:R-PFA-5673000] RAF activation - Plasmodium falciparum
releaseDate
2015-06-17
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5673000
summation
[Summation:5672619] Mammals have three RAF isoforms, A, B and C, that are activa...
Referrals
(hasEvent)
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
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