Reactome | Disassembly of the destruction complex and recruitment of AXIN to the membrane

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Disassembly of the destruction complex and recruitment of AXIN to the membrane Show undefined attributes

authored	[InstanceEdit:3772170] Rothfels, K, 2013-06-24
created	[InstanceEdit:4641261] Rothfels, K, 2013-09-27
crossReference	[DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819475] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	4641262
displayName	Disassembly of the destruction complex and recruitment of AXIN to the membrane
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02 [InstanceEdit:201675] Matthews, L, 2007-09-04 11:49:29
eventOf	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:259757] canonical Wnt signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5323526] FRAT proteins bind GSK3beta - Homo sapiens [BlackBoxEvent:R-HSA-3601585] PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex - Homo sapiens [Reaction:R-HSA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Homo sapiens [Reaction:R-HSA-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Homo sapiens [Reaction:R-HSA-201691] Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI - Homo sapiens [BlackBoxEvent:R-HSA-5368596] WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 - Homo sapiens [Reaction:R-HSA-201685] Beta-catenin is released from the destruction complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:208343] A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation [LiteratureReference:208147] A mechanism for Wnt coreceptor activation [LiteratureReference:208316] Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway [LiteratureReference:1458867] LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way [LiteratureReference:208113] Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex [LiteratureReference:208242] A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression [LiteratureReference:3640796] Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling [LiteratureReference:208391] Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP [LiteratureReference:2130277] Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation [LiteratureReference:4641111] Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex [LiteratureReference:4641122] Modulation of Wnt signaling by Axin and Axil [LiteratureReference:208277] The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway [LiteratureReference:4641109] Wnt signalling pathway parameters for mammalian cells [LiteratureReference:5228653] Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen [LiteratureReference:1458900] Wnt/beta-catenin signaling: components, mechanisms, and diseases
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Disassembly of the destruction complex and recruitment of AXIN to the membrane
orthologousEvent	[Pathway:R-MMU-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Mus musculus [Pathway:R-RNO-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Rattus norvegicus [Pathway:R-CFA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Canis familiaris [Pathway:R-BTA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Bos taurus [Pathway:R-SSC-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Sus scrofa [Pathway:R-DRE-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Danio rerio [Pathway:R-XTR-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Xenopus tropicalis [Pathway:R-GGA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Gallus gallus [Pathway:R-DME-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Drosophila melanogaster
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4641262
summation	[Summation:4641240] Upon stimulation with WNT ligand, AXIN and GSK3beta are recr...
updateTrackers	[UpdateTracker:9786661] Update Tracker - [Pathway:4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - v49:[addHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9781176] Update Tracker - [Pathway:4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - v61:[updateContainedRLE] [UpdateTracker:9780797] Update Tracker - [Pathway:4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - v62:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT

(updatedInstance)

[UpdateTracker:9786661] Update Tracker - [Pathway:4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - v49:[addHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9781176] Update Tracker - [Pathway:4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - v61:[updateContainedRLE]
[UpdateTracker:9780797] Update Tracker - [Pathway:4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - v62:[updateContainedRLE]

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