Reactome | FCERI mediated MAPK activation

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FCERI mediated MAPK activation Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:2871805] Garapati, P V, 2012-12-21
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	2871796
displayName	FCERI mediated MAPK activation
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2730886] Phosphorylation of SHC by SYK kinase - Homo sapiens [Reaction:R-HSA-2730844] Interaction of GRB2:SOS complex with p-SHC1 - Homo sapiens [Reaction:R-HSA-2396599] Recruitment of GRB2:SOS to p-5Y-LAT - Homo sapiens [Reaction:R-HSA-2424477] SOS mediated nucleotide exchange of RAS (SHC) - Homo sapiens [Reaction:R-HSA-2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT - Homo sapiens [Reaction:R-HSA-2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - Homo sapiens [Reaction:R-HSA-2730851] Phosphorylation of SLP-76 by p-SYK - Homo sapiens [Reaction:R-HSA-2730892] Recruitment of VAV to p-SLP-76 - Homo sapiens [Reaction:R-HSA-2730841] Phosphorylation and activation of VAV - Homo sapiens [Reaction:R-HSA-2730840] Activation of RAC1 by VAV - Homo sapiens [Reaction:R-HSA-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Homo sapiens [Reaction:R-HSA-2730856] Autophosphorylation of PAK - Homo sapiens [Reaction:R-HSA-2730887] Autophosphorylation and activation of MEKK1 - Homo sapiens [Reaction:R-HSA-2730896] Phosphorylation of MEK4 by MEKK1 - Homo sapiens [Reaction:R-HSA-2730868] Phosphorylation of MEK7 by MEKK1 - Homo sapiens [Reaction:R-HSA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Homo sapiens [Reaction:R-HSA-450348] Activated human JNKs migrate to nucleoplasm - Homo sapiens [Reaction:R-HSA-168136] Activated JNKs phosphorylate c-JUN - Homo sapiens [Reaction:R-HSA-450325] c-FOS activation by phospho ERK1/2 - Homo sapiens [Reaction:R-HSA-450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:2685220] Adapters in the organization of mast cell signaling [LiteratureReference:4420221] The tyrosine kinase network regulating mast cell activation [LiteratureReference:4420218] Intracellular signaling pathways in IgE-dependent mast cell activation
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	FCERI mediated MAPK activation
orthologousEvent	[Pathway:R-MMU-2871796] FCERI mediated MAPK activation - Mus musculus [Pathway:R-RNO-2871796] FCERI mediated MAPK activation - Rattus norvegicus [Pathway:R-CFA-2871796] FCERI mediated MAPK activation - Canis familiaris [Pathway:R-BTA-2871796] FCERI mediated MAPK activation - Bos taurus [Pathway:R-SSC-2871796] FCERI mediated MAPK activation - Sus scrofa [Pathway:R-DRE-2871796] FCERI mediated MAPK activation - Danio rerio [Pathway:R-XTR-2871796] FCERI mediated MAPK activation - Xenopus tropicalis [Pathway:R-GGA-2871796] FCERI mediated MAPK activation - Gallus gallus [Pathway:R-DME-2871796] FCERI mediated MAPK activation - Drosophila melanogaster [Pathway:R-CEL-2871796] FCERI mediated MAPK activation - Caenorhabditis elegans [Pathway:R-DDI-2871796] FCERI mediated MAPK activation - Dictyostelium discoideum [Pathway:R-SPO-2871796] FCERI mediated MAPK activation - Schizosaccharomyces pombe [Pathway:R-SCE-2871796] FCERI mediated MAPK activation - Saccharomyces cerevisiae
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2871796
summation	[Summation:2871822] Formation of the LAT signaling complex leads to activation o...
updateTrackers	[UpdateTracker:9784712] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v53:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9783568] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v56:[updateContainedPathway] [UpdateTracker:9780815] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v62:[removeHasEvent] [UpdateTracker:9786547] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v49:[modifyText, updateContainedRLE] [UpdateTracker:9787231] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v46:[addLiteratureReference] [UpdateTracker:9781595] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v60:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling

(updatedInstance)

[UpdateTracker:9784712] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v53:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9783568] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v56:[updateContainedPathway]
[UpdateTracker:9780815] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v62:[removeHasEvent]
[UpdateTracker:9786547] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v49:[modifyText, updateContainedRLE]
[UpdateTracker:9787231] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v46:[addLiteratureReference]
[UpdateTracker:9781595] Update Tracker - [Pathway:2871796] FCERI mediated MAPK activation - v60:[updateContainedRLE]

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