Reactome | Signaling by moderate kinase activity BRAF mutants

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Signaling by moderate kinase activity BRAF mutants Show undefined attributes

authored	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
created	[InstanceEdit:6802945] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12325464] BioModels Database:BIOMD0000000467 [DatabaseIdentifier:12325470] BioModels Database:BIOMD0000000427 [DatabaseIdentifier:12325424] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12325370] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12325372] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12325472] BioModels Database:BIOMD0000000832 [DatabaseIdentifier:12325434] BioModels Database:BIOMD0000000659 [DatabaseIdentifier:12325436] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12325474] BioModels Database:BIOMD0000000557 [DatabaseIdentifier:12325344] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12325438] BioModels Database:BIOMD0000000651 [DatabaseIdentifier:12325374] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12325476] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12325430] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12325378] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12325440] BioModels Database:BIOMD0000000288 [DatabaseIdentifier:12325380] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12325478] BioModels Database:BIOMD0000000069 [DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12325480] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12325442] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12325444] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12325446] BioModels Database:BIOMD0000000424 [DatabaseIdentifier:12325382] BioModels Database:BIOMD0000000654
dbId	6802946
disease	[Disease:1500689] cancer
displayName	Signaling by moderate kinase activity BRAF mutants
edited	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
eventOf	[Pathway:R-HSA-6802957] Oncogenic MAPK signaling - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6802915] Moderate kinase activity BRAF mutants bind RAS:GTP - Homo sapiens [Reaction:R-HSA-8936676] Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize - Homo sapiens [Reaction:R-HSA-6802916] RAF is phosphorylated downstream of moderate kinase activity BRAF mutants - Homo sapiens [Reaction:R-HSA-6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-6802919] RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks - Homo sapiens [Reaction:R-HSA-6802921] Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants - Homo sapiens [Reaction:R-HSA-6803230] Dissociation of moderate activity BRAF complexes - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6799043] COSMIC: exploring the world's knowledge of somatic mutations in human cancer [LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling [LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling [LiteratureReference:6790435] Tumor adaptation and resistance to RAF inhibitors [LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Signaling by moderate kinase activity BRAF mutants
normalPathway	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6802946
summation	[Summation:6802205] In addition to the highly prevalent and activating V600E BRA...

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(hasEvent)

[Pathway:R-HSA-6802957] Oncogenic MAPK signaling

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