Reactome | Constitutive Signaling by EGFRvIII

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Constitutive Signaling by EGFRvIII Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
created	[InstanceEdit:5637811] Orlic-Milacic, Marija, 2014-11-12
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819561] BioModels Database:BIOMD0000000594 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819563] BioModels Database:BIOMD0000000223 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819565] BioModels Database:BIOMD0000000595 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	5637810
disease	[Disease:1500689] cancer
displayName	Constitutive Signaling by EGFRvIII
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07 [InstanceEdit:1990858] Jassal, B, 2011-11-07 [InstanceEdit:1990852] Gillespie, ME, 2011-11-07 [InstanceEdit:1990850] Haw, R, 2011-11-07
eventOf	[Pathway:R-HSA-5637812] Signaling by EGFRvIII in Cancer - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1247999] EGFRvIII mutant binds chaperone proteins HSP90 and CDC37 - Homo sapiens [FailedReaction:R-HSA-5638137] EGFRvIII cancer variant does not bind EGF ligand - Homo sapiens [Reaction:R-HSA-1248002] Ligand-independent dimerization of EGFRvIII mutant - Homo sapiens [Reaction:R-HSA-1248655] Trans-autophosphorylation of EGFRvIII mutant dimers - Homo sapiens [Reaction:R-HSA-5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII - Homo sapiens [Reaction:R-HSA-5637806] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) - Homo sapiens [Reaction:R-HSA-5637766] Binding of SHC1 to p-5Y-EGFRvIII - Homo sapiens [Reaction:R-HSA-5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII - Homo sapiens [Reaction:R-HSA-5637798] Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex - Homo sapiens [Reaction:R-HSA-5637808] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) - Homo sapiens [Reaction:R-HSA-5637764] Binding of GRB2:GAB1 complex to p-EGFRvIII mutant - Homo sapiens [Reaction:R-HSA-5637765] Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII - Homo sapiens [Reaction:R-HSA-5637801] Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII - Homo sapiens [Reaction:R-HSA-5637792] PLC-gamma 1 binds to p-EGFRvIII mutant - Homo sapiens [Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant - Homo sapiens [Reaction:R-HSA-5637800] Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant - Homo sapiens [FailedReaction:R-HSA-5637794] EGFRvIII does not bind CBL - Homo sapiens [Reaction:R-HSA-1218824] HSP90 is inactivated by binding to benzaquinoid ansamycins - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2023-03-29
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Constitutive Signaling by EGFRvIII
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5637810
summation	[Summation:5637785] In glioblastoma, the most prevalent EGFR mutation, present i...
updateTrackers	[UpdateTracker:9777905] Update Tracker - [Pathway:5637810] Constitutive Signaling by EGFRvIII - v68:[updateContainedRLE] [UpdateTracker:9846611] Update Tracker - [Pathway:5637810] Constitutive Signaling by EGFRvIII - v84:[modifyText, updateContainedRLE] [UpdateTracker:9780060] Update Tracker - [Pathway:5637810] Constitutive Signaling by EGFRvIII - v64:[updateContainedRLE] [UpdateTracker:9785096] Update Tracker - [Pathway:5637810] Constitutive Signaling by EGFRvIII - v52:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-5637812] Signaling by EGFRvIII in Cancer

(updatedInstance)

[UpdateTracker:9777905] Update Tracker - [Pathway:5637810] Constitutive Signaling by EGFRvIII - v68:[updateContainedRLE]
[UpdateTracker:9846611] Update Tracker - [Pathway:5637810] Constitutive Signaling by EGFRvIII - v84:[modifyText, updateContainedRLE]
[UpdateTracker:9780060] Update Tracker - [Pathway:5637810] Constitutive Signaling by EGFRvIII - v64:[updateContainedRLE]
[UpdateTracker:9785096] Update Tracker - [Pathway:5637810] Constitutive Signaling by EGFRvIII - v52:[updateContainedRLE]

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