Reactome | Integrin signaling

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Integrin signaling Show undefined attributes

authored	[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
created	[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
crossReference	[DatabaseIdentifier:12819497] BioModels Database:BIOMD0000000467 [DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819549] BioModels Database:BIOMD0000000338 [DatabaseIdentifier:12819551] BioModels Database:BIOMD0000000340 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819509] BioModels Database:BIOMD0000000069 [DatabaseIdentifier:12819559] BioModels Database:BIOMD0000000339 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	354192
deleted	[Deleted:9666754] Deletion of instance: 9006921
displayName	Integrin signaling
doi	10.3180/REACT_15523.1
edited	[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
eventOf	[Pathway:R-HSA-76009] Platelet Aggregation (Plug Formation) - Homo sapiens [TopLevelPathway:R-HSA-162582] Signal Transduction - Homo sapiens
figure	[Figure:372831] /figures/GPIIbII3inside_out.png
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-354173] Activation of Rap1 by cytosolic GEFs - Homo sapiens [Reaction:R-HSA-939265] Activation of Rap1 by membrane-associated GEFs - Homo sapiens [Reaction:R-HSA-354060] Translocation of RIAM to plasma membrane - Homo sapiens [Reaction:R-HSA-354097] Activation of Talin - Homo sapiens [Reaction:R-HSA-354077] Integrin alphaIIb beta3 activation - Homo sapiens [Reaction:R-HSA-354149] Interaction of integrin alphaIIb beta3 with Fibrinogen - Homo sapiens [Reaction:R-HSA-377641] Clustering of Integrin alphaIIb beta3 complexes - Homo sapiens [Reaction:R-HSA-377644] Release of CSK from SRC - Homo sapiens [Reaction:R-HSA-377643] Dephosphorylation of inactive SRC by PTPB1 - Homo sapiens [Reaction:R-HSA-377640] Autophosphorylation of SRC - Homo sapiens [Reaction:R-HSA-354066] Translocation of PTK2 to Focal complexes - Homo sapiens [Reaction:R-HSA-354073] Autophosphorylation of PTK2 at Y397 - Homo sapiens [Reaction:R-HSA-354124] Phosphorylation of pPTK2 by SRC - Homo sapiens [Pathway:R-HSA-354194] GRB2:SOS provides linkage to MAPK signaling for Integrins - Homo sapiens [Pathway:R-HSA-372708] p130Cas linkage to MAPK signaling for integrins - Homo sapiens [Reaction:R-HSA-432110] Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding - Homo sapiens [Reaction:R-HSA-432096] Activated integrin alphaIIb beta3 binds SHC1 - Homo sapiens [BlackBoxEvent:R-HSA-443905] SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow - Homo sapiens [BlackBoxEvent:R-HSA-443910] SHC1 dissociates from integrin alphaIIb beta3 - Homo sapiens [Reaction:R-HSA-429415] SYK binds to integrin alphaIIb beta3 - Homo sapiens [Reaction:R-HSA-429441] SYK activation by SRC - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-12-10
literatureReference	[LiteratureReference:1498703] Signalling via integrins: implications for cell survival and anticancer strategies [LiteratureReference:9007248] Integrin signalling at a glance [LiteratureReference:9007251] Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer [LiteratureReference:210067] GPVI and integrin alphaIIb beta3 signaling in platelets [LiteratureReference:354123] Platelet integrins and immunoreceptors [LiteratureReference:377578] Integrins: dynamic scaffolds for adhesion and signaling in platelets [LiteratureReference:354175] Integrin activation [LiteratureReference:354141] Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation [LiteratureReference:140237] Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Integrin signaling
orthologousEvent	[Pathway:R-MMU-354192] Integrin signaling - Mus musculus [Pathway:R-RNO-354192] Integrin signaling - Rattus norvegicus [Pathway:R-CFA-354192] Integrin signaling - Canis familiaris [Pathway:R-BTA-354192] Integrin signaling - Bos taurus [Pathway:R-SSC-354192] Integrin signaling - Sus scrofa [Pathway:R-DRE-354192] Integrin signaling - Danio rerio [Pathway:R-XTR-354192] Integrin signaling - Xenopus tropicalis [Pathway:R-GGA-354192] Integrin signaling - Gallus gallus [Pathway:R-DME-354192] Integrin signaling - Drosophila melanogaster [Pathway:R-CEL-354192] Integrin signaling - Caenorhabditis elegans [Pathway:R-DDI-354192] Integrin signaling - Dictyostelium discoideum [Pathway:R-SCE-354192] Integrin signaling - Saccharomyces cerevisiae
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:377695] Shattil, SJ, 2008-09-16 06:21:39
revised	[InstanceEdit:1215946] Garapati, P V, 2011-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-354192
summation	[Summation:354186] Integrins are a major family of cell surface receptors that ...
updateTrackers	[UpdateTracker:9790237] Update Tracker - [Pathway:354192] Integrin signaling - v34:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9786697] Update Tracker - [Pathway:354192] Integrin signaling - v49:[modifyText] [UpdateTracker:9791627] Update Tracker - [Pathway:354192] Integrin signaling - v28:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9791171] Update Tracker - [Pathway:354192] Integrin signaling - v32:[removeHasEvent] [UpdateTracker:9782577] Update Tracker - [Pathway:354192] Integrin signaling - v59:[updateIndirectRLE] [UpdateTracker:9791395] Update Tracker - [Pathway:354192] Integrin signaling - v30:[updateContainedRLE] [UpdateTracker:9787629] Update Tracker - [Pathway:354192] Integrin signaling - v44:[updateIndirectRLE] [UpdateTracker:9790530] Update Tracker - [Pathway:354192] Integrin signaling - v33:[addHasEvent] [UpdateTracker:9789668] Update Tracker - [Pathway:354192] Integrin signaling - v37:[modifyText, updateIndirectRLE] [UpdateTracker:9791524] Update Tracker - [Pathway:354192] Integrin signaling - v29:[updateIndirectRLE] [UpdateTracker:9790010] Update Tracker - [Pathway:354192] Integrin signaling - v36:[updateContainedRLE] [UpdateTracker:9784828] Update Tracker - [Pathway:354192] Integrin signaling - v53:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791300] Update Tracker - [Pathway:354192] Integrin signaling - v31:[addHasEvent, addLiteratureReference] [UpdateTracker:9778157] Update Tracker - [Pathway:354192] Integrin signaling - v68:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777428] Update Tracker - [Pathway:354192] Integrin signaling - v71:[addLiteratureReference, modifyText]

Referrals

(hasEvent)	[TopLevelPathway:R-HSA-162582] Signal Transduction [Pathway:R-HSA-76009] Platelet Aggregation (Plug Formation)
(replacementInstances)	[Deleted:9666754] Deletion of instance: 9006921
(updatedInstance)	[UpdateTracker:9790237] Update Tracker - [Pathway:354192] Integrin signaling - v34:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9786697] Update Tracker - [Pathway:354192] Integrin signaling - v49:[modifyText] [UpdateTracker:9791627] Update Tracker - [Pathway:354192] Integrin signaling - v28:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9791171] Update Tracker - [Pathway:354192] Integrin signaling - v32:[removeHasEvent] [UpdateTracker:9782577] Update Tracker - [Pathway:354192] Integrin signaling - v59:[updateIndirectRLE] [UpdateTracker:9791395] Update Tracker - [Pathway:354192] Integrin signaling - v30:[updateContainedRLE] [UpdateTracker:9787629] Update Tracker - [Pathway:354192] Integrin signaling - v44:[updateIndirectRLE] [UpdateTracker:9790530] Update Tracker - [Pathway:354192] Integrin signaling - v33:[addHasEvent] [UpdateTracker:9789668] Update Tracker - [Pathway:354192] Integrin signaling - v37:[modifyText, updateIndirectRLE] [UpdateTracker:9791524] Update Tracker - [Pathway:354192] Integrin signaling - v29:[updateIndirectRLE] [UpdateTracker:9790010] Update Tracker - [Pathway:354192] Integrin signaling - v36:[updateContainedRLE] [UpdateTracker:9784828] Update Tracker - [Pathway:354192] Integrin signaling - v53:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791300] Update Tracker - [Pathway:354192] Integrin signaling - v31:[addHasEvent, addLiteratureReference] [UpdateTracker:9778157] Update Tracker - [Pathway:354192] Integrin signaling - v68:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777428] Update Tracker - [Pathway:354192] Integrin signaling - v71:[addLiteratureReference, modifyText]

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