Reactome | Binding of TCF/LEF:CTNNB1 to target gene promoters

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Binding of TCF/LEF:CTNNB1 to target gene promoters Show undefined attributes

authored	[InstanceEdit:4415000] Rothfels, K, 2013-08-23
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4411356] Rothfels, K, 2013-08-23
crossReference	[DatabaseIdentifier:12819433] BioModels Database:BIOMD0000000653 [DatabaseIdentifier:12819435] BioModels Database:BIOMD0000000656 [DatabaseIdentifier:12819475] BioModels Database:BIOMD0000000149 [DatabaseIdentifier:12819437] BioModels Database:BIOMD0000000648 [DatabaseIdentifier:12819441] BioModels Database:BIOMD0000000655 [DatabaseIdentifier:12819443] BioModels Database:BIOMD0000000652 [DatabaseIdentifier:12819445] BioModels Database:BIOMD0000000654
dbId	4411364
displayName	Binding of TCF/LEF:CTNNB1 to target gene promoters
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02 [InstanceEdit:201675] Matthews, L, 2007-09-04 11:49:29
eventOf	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-4411367] TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene - Homo sapiens [BlackBoxEvent:R-HSA-4411357] TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene - Homo sapiens [Reaction:R-HSA-4411351] TCF/LEF:CTNNB1 bind the AXIN2 gene - Homo sapiens [BlackBoxEvent:R-HSA-4411372] TCF/LEF:CTNNB1 promote transcription of AXIN2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-03-26
literatureReference	[LiteratureReference:4641115] The first five years of the Wnt targetome [LiteratureReference:4641110] Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor [LiteratureReference:4641119] FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development [LiteratureReference:4411400] Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors [LiteratureReference:4641123] Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Binding of TCF/LEF:CTNNB1 to target gene promoters
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4411364
summation	[Summation:4641233] The genes regulated by beta-catenin and TCF/LEF are involved...
updateTrackers	[UpdateTracker:9781817] Update Tracker - [Pathway:4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters - v60:[updateContainedRLE] [UpdateTracker:9780045] Update Tracker - [Pathway:4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters - v64:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9781817] Update Tracker - [Pathway:4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters - v60:[updateContainedRLE] [UpdateTracker:9780045] Update Tracker - [Pathway:4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters - v64:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex

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